Clinicopathological characteristics of de novo and secondary myeloid sarcoma: A monocentric retrospective study

Claerhout, Helena; Aelst, Sophie Van; Melis, C.; Tousseyn, Thomas; Gheysens, Olivier; Vandenberghe, Peter; Dierickx, Daan; Boeckx, Nancy

doi:10.1111/ejh.13056

Cited by 31 publications

(33 citation statements)

References 22 publications

(138 reference statements)

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“…Similarly, a recent study on 72 patients with MS performed by Claerhout et al . showed that cutaneous MS had a significantly shorter overall survival compared to the other sites ( P = 0.0167) . Goyal et al .…”

Section: Discussionmentioning

confidence: 96%

“…16 Similarly, a recent study on 72 patients with MS performed by Claerhout et al showed that cutaneous MS had a significantly shorter overall survival compared to the other sites (P = 0.0167). 17 Goyal et al stratified 746 MS patients based on tumour locations into prognostic groups: good (OS > 30 months: reproductive and digestive system), intermediate (OS = 15-30 months, head/neck, skin/ breast, and kidney/bladder/retroperitoneum/adrenal) and poor (OS < 15 months: nervous system, connective/soft tissue, lymph nodes/spleen, cardiac/mediastinal and bones/joints). 18 Goyal et al hypothesised that reproductive and digestive system MS may have a better prognosis due to earlier symptom onset, while bone MS may indicate onset of bone marrow involvement.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological and molecular characteristics of extramedullary acute myeloid leukaemia

et al. 2019

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Aims Myeloid sarcoma (MS) is a rare extramedullary neoplasm composed of immature myeloid precursor cells thought to be a unique clinical presentation of acute myeloid leukaemia (AML). Like AML, MS has a poor prognosis, but due to the rare nature of MS there are limited studies examining potential prognostic factors. We report our institutional experience, with the aim of investigating and establishing salient clinicopathological and molecular features of MS. Methods and results We retrospectively examined all clinicopathological and molecular data on MS patients between 2001 and 2017 from the University of Alabama at Birmingham (UAB) electronic medical records. The UAB electronic medical records were also reviewed and compared with the literature for other potential prognostic factors. Sixty‐three patients were included in the study. The median overall survival was 24 months in the group with normal karyotype and 12 months in patients with an abnormal karyotype. Conclusions We found that an abnormal karyotype was associated with a statistically significant worse prognosis.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Clinicopathological and molecular characteristics of extramedullary acute myeloid leukaemia

et al. 2019

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“…It is usually associated with acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and other myeloproliferative disorders and can present as soft tissue swelling. Granulocytic sarcomas are usually found in skin, bones and lymph nodes. Though difficult to differentiate on the basis of morphology alone, this differential is excluded by normal peripheral blood picture, bone marrow examination and immunophenotyping.…”

Section: Discussionmentioning

confidence: 99%

“…Additional metastasis of the primary, is further associated with a worse prognosis. No optimal treatment protocol is established yet, and a combination of modalities, including surgery and chemotherapy, has been suggested . The role of adrenalectomy for diagnosis and therapy is debatable.…”

Section: Discussionmentioning

confidence: 99%

Cytological diagnosis of bilateral primary adrenal lymphoma with cutaneous involvement

Rakheja

Handa

Kaur

et al. 2020

Diagnostic Cytopathology

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Primary adrenal lymphoma (PAL) is an extremely rare condition. We describe here, a case of bilateral adrenal lymphoma in a 62‐year‐old man. He later developed subcutaneous masses on the hand and the leg. Fine‐needle aspiration cytology from the adrenals and the soft tissue swellings led to a diagnosis of non‐Hodgkin's lymphoma (NHL). Histopathological examination from the lesion on the leg, confirmed the diagnosis to be B‐cell NHL. The case highlights the cytomorphological findings of this unusual case. Awareness of this entity is essential to differentiate it from other common causes of adrenal enlargement and formulate an appropriate treatment.

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“…MS most commonly manifests in the skin, subcutaneous tissues, and the lymph nodes. Claerhout et al conducted a case series of 41 patients with de novo MS and 31 patients with secondary disease [19]. Among both cohorts, respectively, they found that MS localized to the skin in 24-25.5% of cases, lymph nodes (18.2-16.0%), gastrointestinal tract [20] (10.9-2.0%), breast (7.3-10.0%), ovary (3.6-0.0%), cervix/urine corpus (1.8-4.0%), bone (3.6-6.0%), and brain (3.6-6.0%).…”

Section: Discussionmentioning

confidence: 99%

Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract

Kahn

Gordhandas

Chapman‐Davis

et al. 2019

Case Reports in Oncological Medicine

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Myeloid sarcoma (MS) is a rare, extramedullary tumor consisting of immature white blood cells of myeloid lineage. MS is usually associated with the concurrent diagnosis of acute myeloid leukemia (AML) but can also present in the absence of bone marrow disease or at relapse of AML. MS of the gynecologic tract is exceedingly rare; however, it is hypothesized that it is likely more prevalent than previously understood given postmortem findings and persistence in preserved ovarian tissue. There is minimal literature surrounding MS and extramedullary relapse with no clear guidelines. This is a case report of a 48-year-old woman with MS involving the uterine corpus, fallopian tubes, and left ovary followed by a literature review. The overall aim is to review data regarding leukemic immune evasion and sanctuary sites in order to raise awareness as this represents an important and underrecognized hematologic malignancy in an often misdiagnosed, underrecognized site.

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Clinicopathological characteristics of de novo and secondary myeloid sarcoma: A monocentric retrospective study

Abstract: De novo myeloid sarcoma mostly presented isolated. Lesions were often localized at skin and lymph nodes. Genetic aberrations frequently involved core-binding factor rearrangements in de novo cases and a complex karyotype in secondary cases.

Cited by 31 publications

References 22 publications

Clinicopathological and molecular characteristics of extramedullary acute myeloid leukaemia

Clinicopathological and molecular characteristics of extramedullary acute myeloid leukaemia

Cytological diagnosis of bilateral primary adrenal lymphoma with cutaneous involvement

Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract

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