Clinicopathological Characteristics and Prognosis of Breast Cancer in Young Women – A Single Center Study in a Developing Country

Sun, Xin; Li, Jun; Ji, Haoyang; Yang, Meng; Lu, Yiming

doi:10.2147/cmar.s299066

Cited by 9 publications

(7 citation statements)

References 34 publications

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“…We found that the black race had a higher risk of cumulative incidence and a poor prognosis, keeping in with previous studies 14,15 . Consistent with previous studies, BCYW has a predisposition to have high-grade tumors, visceral metastases, negative estrogen receptors, and positive HER2 status [19][20][21] . Kaplan-Meier curves suggest that patients under 40 years have longer OS and BCSS than older patients.…”

Section: Discussionsupporting

confidence: 90%

Survival and prognosis of metastatic breast cancer in young women: SEER 2010-2015

Sun

Dai

et al. 2023

Preprint

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Although breast cancer in young women (BCYW) is not as common as in older individuals, the incidence of BCYW is increasing. Due to the particular considerations regarding pregnancy, fertility preservation, early menopause, body image, lactation, and quality of life, BCYW deserves unique management. We sought to estimate the survival and prognosis of such patients. In this article, we extracted 9761 primary breast cancer patients' data between 2010 and 2015 from the Surveillance Epidemiology and End Results (SEER) database. We included patients under 70 years and divided them into two groups by age (＜40 vs. 40-69 years). We defined the clinicopathologic characteristics, comprehensively analyzed and compared the OS and BCSS of breast cancer between two age groups among tumor subtypes. Patients under 40 years have longer OS and BCSS than older patients, while these survival benefits are limited in HR+ or/and HER2+ patients, except for TNBC, which needs further investigation. In addition, we developed an efficient predictive nomogram to predict 1-, 3- and 5-year OS of metastatic BCYW. These nomograms can aid oncologists in distinguishing, assessing and evaluating the risk and prognosis of metastatic BCYW, which can help oncologists select the next treatment strategies for BCYW.

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Section: Discussionsupporting

confidence: 90%

Survival and prognosis of metastatic breast cancer in young women: SEER 2010-2015

Sun

Dai

et al. 2023

Preprint

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“…Although luminal-A disease is associated with better prognosis, biological subtyping showed no difference between age groups, similar to the literature ( 6 , 21 , 23 ). Thus, differences in survival between age groups could not be related to only the biological subtype distribution.…”

Section: Discussionsupporting

confidence: 89%

“…The hormonal and Her-2 status in group Y was similar to that reported by Cancello et al ( 19 ). Sun et al ( 23 ) showed a significantly higher hormone negativity in young patients than in other developing countries.…”

Section: Discussionmentioning

confidence: 94%

Do prognosis and clinicopathological features differ in young early-stage breast cancer?

Arıkan

Dülgeroğlu²,

Erdoğan³

et al. 2022

Front. Surg.

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BackgroundBreast cancer is the most frequently detected cancer and the leading cause of cancer-related death in women. Although it is mostly seen in older patients, breast cancer affects women aged 24 to >70 years, with poorer prognosis in young patients. Young age remains a controversial topic in the literature. This study aimed to identify subtype differences and the effect of age on early-stage breast cancer outcomes.MethodsA total of 300 consecutive patients underwent surgery between 2011 and 2015 for early-stage breast cancer. Of these, 248 were eligible for this study and were divided into three groups: group Y (aged ≤35 years), group M (aged >35 and ≤45 years), and group E (aged >45 years). The clinical and pathological features and data related to recurrence, metastasis, and death were recorded.ResultsNo statistical differences were found between groups regarding histopathological features except for higher histological grade and Ki-67 levels in group M. Additionally, group Y recorded no progression (recurrence or metastasis) or death. Disease-free survival was 117.8 months (95% CI 111.8–123.8) for group M, which was significantly shorter than that for group E (p < 0.001). Additionally, the hazard ratio (HR) for progression from group M to group E was 10.21 with significant difference (p = 0.003, 95% CI 2.26–46.08). However, the HR of group Y to group E was 0.04, without significance (p = 0.788, 95% CI 0.18–345 × 106). The overall 5-year survival was 100% in group Y, 98.8% in group M, and 99.3% in group E, without significance.ConclusionA very young age cannot be considered an independent risk factor for poor prognosis. Rather than age, histological grade and Ki-67 index are more important factors in early-stage breast cancer.

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“…Compared with elderly women, young patients, accounting for a relatively small number of breast cancer, were more likely to present aggressive subtypes and advanced disease, and the survival and outcomes were worse (5-year relative survival rate comparison: 86% vs 91% in elderly women) ( 5 ). Consequently, the strategies of treatment and prevention for young breast cancer have gradually aroused wide attention ( 7 – 11 ). Notably, in one study from China, young patients with breast cancer were more likely to have larger tumor size, poorer differentiation grade, a higher proportion of triple-negative breast cancer (TNBC), and more advanced stage, when compared with elder patients ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, the strategies of treatment and prevention for young breast cancer have gradually aroused wide attention ( 7 – 11 ). Notably, in one study from China, young patients with breast cancer were more likely to have larger tumor size, poorer differentiation grade, a higher proportion of triple-negative breast cancer (TNBC), and more advanced stage, when compared with elder patients ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Cancer-Specific Survival Outcome in Early-Stage Young Breast Cancer: Evidence From the SEER Database Analysis

Xiao

et al. 2022

Front. Endocrinol.

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BackgroundYoung women with breast cancer are determined to present poorer survival compare with elderly patients. Therefore, identifying the clinical prognostic factors in young women with early-stage (T1-2N0-1M0) breast cancer is pivotal for surgeons to make better postoperative management.MethodsThe clinicopathological characteristics of female patients with early-stage breast cancer from the Surveillance, Epidemiology, and End Results program between Jan 2010 and Dec 2015 were retrospectively reviewed and analyzed. Univariate and multivariate Cox regression analyses were used to determine the potential risk factors of cancer-specific survival in young women with early-stage breast cancer. The nomogram was constructed and further evaluated by an internal validation cohort. The Kaplan-Meier survival curves were used to estimate cancer-specific survival probability and the cumulative incidence.ResultsSix variables including race, tumor location, grade, regional lymph node status, tumor subtype, and size were identified to be significantly associated with the prognosis of young women with early-stage breast cancer during the postoperative follow-up. A nomogram for predicting the 3-, 5- year cancer-specific survival probability in this subpopulation group was established with a favorable concordance index of 0.783, supported by an internal validation cohort with the AUC of 0.722 and 0.696 in 3-, 5- year cancer-specific survival probability, respectively.ConclusionsThe first predictive nomogram containing favorable discrimination is successfully established and validated for predicting the 3-, 5- year cancer-specific survival probability in young women with early-stage breast cancer during the postoperative follow-up. This model would help clinicians to make accurate treatment decisions in different clinical risk population.

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Clinicopathological Characteristics and Prognosis of Breast Cancer in Young Women – A Single Center Study in a Developing Country

Cited by 9 publications

References 34 publications

Survival and prognosis of metastatic breast cancer in young women: SEER 2010-2015

Survival and prognosis of metastatic breast cancer in young women: SEER 2010-2015

Do prognosis and clinicopathological features differ in young early-stage breast cancer?

Cancer-Specific Survival Outcome in Early-Stage Young Breast Cancer: Evidence From the SEER Database Analysis

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