Clinicopathological Characteristics and Long‐term Outcome in Patients with Distant Metastases from Differentiated Thyroid Cancer

Benbassat, Carlos; Mechlis-Frish, Sara; Hirsch, Dania

doi:10.1007/s00268-005-0472-4

Cited by 107 publications

(87 citation statements)

References 31 publications

(62 reference statements)

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“…With conventional treatments (surgery, radioiodine, hormone suppression), distant metastases (DM) occur in 3%-7% of cases, most often in the lung [1,2].Treatment of DM patients is based on radioiodine and associated with hormone suppression and locoregional therapies [3,4]. Twothirds of DM patients have 131 I uptake on therapeutic 131 I wholebody scan ( 131 I-WBS), and a half of these achieve remission.…”

Section: Introductionmentioning

confidence: 99%

Outcomes and Prognostic Factors in Radioiodine Refractory Differentiated Thyroid Carcinomas

et al. 2015

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Background. Outcomes vary among patients with radioiodine refractory (RR) differentiated thyroid cancer (DTC). The prognostic factors for survival are not well-known, resulting in difficulty in selectingpatients for newtargetedtherapies.We assessed overall survival (OS) and cancer-specific survival (CSS) from RR-DTC to identify prognostic factors associated with survival. Patients and Methods. The data on all cases of metastatic RR-DTC treated in our center from 1990 to 2011 were retrospectively reviewed. Survival was estimated using the Kaplan-Meier method; associated prognostic factors were assessed using Cox's model. Results. Of 153 cases of metastatic DTC, 59% (n 5 91) met a criterion for RR: that is, 60% (n 5 55) had at least 1 metastasis without

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Section: Introductionmentioning

confidence: 99%

Outcomes and Prognostic Factors in Radioiodine Refractory Differentiated Thyroid Carcinomas

et al. 2015

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“…Distant metastasis occurs in 4-23% of DTC patients and the lung is the most frequent site of distant metastasis (1-7). The 10-year survival rate after a diagnosis of metastatic DTC ranges from 25% to 70%, and patients with metastatic DTC have markedly varying clinical outcomes from rapid progression and death to complete remission, suggesting a heterogeneity in those patients (2,6,(8)(9)(10)(11)(12)(13)(14). Several retrospective studies have shown that the prognostic factors for the survival of metastatic DTC include age at diagnosis (9,14,15), histology of the tumor (14,16), site of metastasis (14,15), and 131 I avidity (9,15,16).…”

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confidence: 99%

Long-Term Prognosis of Differentiated Thyroid Cancer with Lung Metastasis in Korea and Its Prognostic Factors

Cho

Choi²,

Yeom³

et al. 2014

Thyroid

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Background: Distant metastasis, generally to lung and bone, is rare in differentiated thyroid carcinoma (DTC) and the prognosis is still elusive. We investigated long-term outcomes of lung metastasis in DTC patients and its prognostic factors. Methods: A retrospective review was performed of 4572 patients who underwent surgery for DTC from 1962 to 2009 at Seoul National University Hospital. Among them, 164 patients were identified with lung metastasis and 152 patients were enrolled in the final analysis. Poor prognosis was defined as progressive disease or death. Results: Of these 152 patients, 10-and 20-year survival rates were 85.0% and 71.0%, respectively. No evidence of disease, stable disease, progressive disease, and death was identified in 22.4%, 28.3%, 35.5%, and 13.8%, respectively, after 11 years of median follow-up (range 2-41 years). Older age at diagnosis ( ‡ 45 years), primary tumor size ‡ 2 cm, follicular thyroid cancer, metastasis diagnosed after initial evaluation or 131 I remnant ablation (late metastasis), multiple metastases other than lung, 131 I nonavidity, and the presence of macronodules ( ‡ 1 cm) were more frequent in poor prognoses. Cox proportional hazard ratio for progression-free survival showed that 131 I nonavidity was the only independent predictive factor for poor prognosis. Conclusions: The prognosis of lung metastasis from DTC in Korea within this study was favorable.

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“…Reported rates of occurrence of distant metastases in DTC range from 6% to 20% with variation between papillary and follicular subtypes (9). Metastatic disease in DTC has a more favorable course than others malignancies with widespread dissemination, with 10-year survival rates of 50% in the majority of series.…”

Section: Discussionmentioning

confidence: 99%

Soft tissue metastases from differentiated thyroid cancer diagnosed by 18F FDG PET-CT

Califano

Quildrian

Coduti

et al. 2013

Arq Bras Endocrinol Metab

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SUMMARYDistant metastases of differentiated thyroid cancer are unusual; lung and bones are the most frequently affected sites. Soft tissue metastases (STM) are extremely rare. We describe two cases of patients with differentiated thyroid cancer metastasizing to soft tissues. Both patients had widespread metastatic disease; clinically asymptomatic soft tissue metastases were found by SUMÁRIOAs metástases a distância em carcinoma diferenciado de tireoide são raras. Pulmão e ossos são os lugares mais frequentemente atingidos. As metástases em tecidos moles são extremamente infrequentes. Neste artigo, descrevemos dois casos de pacientes com câncer diferenciado de tireoide com metástases em tecidos moles. Ambos os pacientes padeciam de enfermidade avançada. As metástases em partes moles foram assintomáticas e detectadas mediante

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Clinicopathological Characteristics and Long‐term Outcome in Patients with Distant Metastases from Differentiated Thyroid Cancer

Abstract: We conclude that complete resection of the thyroid gland at diagnosis and high-dose adjuvant radioactive iodine are associated with improved survival in patients with metastatic DTC.

Cited by 107 publications

References 31 publications

Outcomes and Prognostic Factors in Radioiodine Refractory Differentiated Thyroid Carcinomas

Outcomes and Prognostic Factors in Radioiodine Refractory Differentiated Thyroid Carcinomas

Long-Term Prognosis of Differentiated Thyroid Cancer with Lung Metastasis in Korea and Its Prognostic Factors

Soft tissue metastases from differentiated thyroid cancer diagnosed by 18F FDG PET-CT

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