Clinicopathological and Ultrasonic Features of Triple-Negative Breast Cancers: A Comparison with Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor-2-Negative Breast Cancers

Wang, Dongmo; Zhu, Kai; Tian, Jing; Li, Ziyao; Du, Guoqing; Guo, Qiang; Wu, Tong; Li, Juan

doi:10.1016/j.ultrasmedbio.2018.01.013

Cited by 23 publications

(31 citation statements)

References 26 publications

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“…1, 3,4 In this study, we found that most of patients had T3 (58.2%), N1 (52.7%), M0 (96,4%), and clinical stage III (33 cases) such as IIIB (34.5%). This study is in accordance with Yuan et al but opposite with Wang et al 10,11 Wang et al (2018) found that approximately 60% of cases didn't metastasize to lymph node. 11 This study results were varied widely because of various sample sized, different races, and patients' desire to seek treatment.…”

Section: Resultssupporting

confidence: 91%

“…This study is in accordance with Yuan et al but opposite with Wang et al 10,11 Wang et al (2018) found that approximately 60% of cases didn't metastasize to lymph node. 11 This study results were varied widely because of various sample sized, different races, and patients' desire to seek treatment. In Indonesia, patients often came for treatment when late stage because of low health education and dependence on traditional medicine (herbal).…”

Section: Resultssupporting

confidence: 91%

“…1,3,4 This study results were in accordance with other studies. 8,10,11 In cancer, cell proliferation is one of the most important prognostic factors. This correlates with overall patient survival rate.…”

Section: Resultsmentioning

confidence: 99%

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Ki-67 Labeling Index Based on Clinicopathological Characteristics in Triple Negative Breast Carcinoma (TNBC)

Leo¹,

Delyuzar²,

Betty³

2018

IJCTR

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Nowadays, breast cancer has been known as heterogenous disease with various biological features which require different therapy strategies. Breast cancers with lack or no expression of estrogen (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER-2) are defined as triple negative breast cancer (TNBC). To date, Ki-67 has been used in order to characterize cell proliferation. This study is to analyze Ki-67 labeling index (LI) expression based on clinicopathological features of TNBC. This descriptive study with cross-sectional design was performed. Data about demographics were extracted from patients' medical record and histopathologic feature and immunohistochemistry was done. Results of analysis data were presented in frequency tables. Mean and standard deviation Ki-67 LI were also obtained. In this study, most patients aged 35-49 years old with mean of 46,8 years old. Most of them had bigger tumour size, had already metastasized to lymph node, had no distant metastases and higher stage. Ki-67 LI value in this study quite high with mean of 43,89%. %. If TNBC patients were young, had distant metastases, higher mitotic count (≥15/10 HPF) and higher grade, they tended to have higher Ki-67 LI. Patients with metaplastic carcinoma of no special type and carcinoma with medullary features also tended to have higher Ki-67 LI. Meanwhile tumour size, metastases to lymph node and clinical stage were not in accordance with Ki-67 LI.

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 91%

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Ki-67 Labeling Index Based on Clinicopathological Characteristics in Triple Negative Breast Carcinoma (TNBC)

Leo¹,

Delyuzar²,

Betty³

2018

IJCTR

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“…A total of 620 patients with TNBC, with ages ranging from 28 to 95 years, were included in the analysis. Of the included studies, 8 studies focused on the evaluation of the tumor shape of TNBC, all of which showed that the occurrence rate of a “round/oval shape” in TNBC was higher than that in non‐TNBC. Of the included studies, there were 7 studies evaluating the tumor margin of TNBC.…”

Section: Resultsmentioning

confidence: 99%

“…They observed that TNBC showed circumscribed or lobulated margins more frequently than spiculated or angular margins. In contrast, Wang et al concluded that TNBCs were likely to be masses with indistinct (40%), microlobulated (33%), or circumscribed/smooth (27%) margins on US imaging. Li et al suggested that TNBCs were less likely to display an echogenic halo boundary than non‐TNBCs.…”

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confidence: 97%

Systematic Review and Meta‐analysis of the Malignant Ultrasound Features of Triple‐Negative Breast Cancer

Tian

Wang

Qin

et al. 2020

J of Ultrasound Medicine

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Objectives-The malignant ultrasound (US) features of breast cancer are known to include an irregular shape, a noncircumscribed margin, an echogenic halo, a nonparallel orientation, posterior acoustic attenuation, microcalcification, and others. However, these US features are uncertain and controversial for the diagnosis of triple-negative breast cancer (TNBC). This study aimed to analyze the diagnostic value of malignant US features for TNBC by a systematic review and meta-analysis, analyze the US characteristics of TNBC, and provide US evidence for clinical diagnosis. Methods-A comprehensive search was performed to identify relevant English articles concerning the US diagnosis of TNBC (from the date of database establishment to November 2019). The pooled sensitivity, pooled specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio with 95% confidence interval, summary receiver operating characteristic curve, and area under the curve for the different malignant US features were calculated. Results-Ten studies (620 patients) met the eligibility criteria. The sensitivity (range, 0.14-0.68) and specificity (range, 0.19-0.66) of the malignant US features were not high. Summary receiver operating characteristic curves showed that the area under the curve (range, 0.25-0.47) of the malignant US features was low, demonstrating that these features have poor diagnostic value for TNBC. The positive likelihood ratio (range, 0.4-to 0.9) of the malignant US features was low, and the negative likelihood ratio (range, 1.09-2.02) was not low, revealing that these features had a poor ability to confirm or exclude TNBC. Conclusions-Triple-negative breast cancer lacks the typical malignant US features of breast cancer and has its own US features. Key Words-malignant ultrasound features; meta-analysis; systematic review; triple-negative breast cancer B reast cancer is one of the most common malignant tumors in women. Its incidence is rapidly rising in most countries. 1-3 Triple-negative breast cancer (TNBC) is a distinct subtype of breast cancer that lacks the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 and is characterized by high malignancy, poor tissue differentiation, and strong invasive ability. 4-6 Therefore, the early diagnosis of TNBC is very important to provide appropriate therapy. Endocrine therapies and targeted therapies are ineffective for TNBC. Some studies have shown that patients with TNBC are more likely to have a complete pathologic response with neoadjuvant chemotherapy than those without TNBC. 7,8 At present, the diagnosis of

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Heterogeneity of Triple‐Negative Breast Cancer: Differences in Clinicopathologic and Ultrasound Features Between Premenopausal and Postmenopausal Patients

Zhu

Wang

et al. 2019

J of Ultrasound Medicine

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Objectives-The aim of this study was to determine whether any salient differences exist in triple-negative breast cancer (TNBC) between premenopausal and postmenopausal patients by comprehensively comparing the ultrasound (US) and clinicopathologic features of these patients.Methods-A detailed evaluation of the US and clinicopathologic features of 60 tumors from 60 patients with a diagnosis of TNBC (36 premenopausal and 24 postmenopausal women) was conducted in this retrospective study.Results-Triple-negative breast cancer in premenopausal patients was more likely to show a round or oval shape and microlobulated margins, more commonly exerted effects on surrounding tissue, and showed grade 3 blood flow according to the method of Adler et al (Ultrasound Med Biol 1990; 16:553-559) compared with tumors in postmenopausal women. Triple-negative breast cancer in postmenopausal patients showed some similar US features as those observed in estrogen receptor-positive tumors, including irregular shapes, angular or spiculated margins, and nonparallel growth to the skin (P < .05 for all).Conclusions-Although US cannot be used to unequivocally identify TNBC, it can distinguish some salient US features regarding TNBC between premenopausal and postmenopausal women. Such information can then provide some valuable predictive information on the diagnosis of TNBC for clinicians.

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Clinicopathological and Ultrasonic Features of Triple-Negative Breast Cancers: A Comparison with Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor-2-Negative Breast Cancers

Cited by 23 publications

References 26 publications

Ki-67 Labeling Index Based on Clinicopathological Characteristics in Triple Negative Breast Carcinoma (TNBC)

Ki-67 Labeling Index Based on Clinicopathological Characteristics in Triple Negative Breast Carcinoma (TNBC)

Systematic Review and Meta‐analysis of the Malignant Ultrasound Features of Triple‐Negative Breast Cancer

Heterogeneity of Triple‐Negative Breast Cancer: Differences in Clinicopathologic and Ultrasound Features Between Premenopausal and Postmenopausal Patients

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