Clinicopathological and survival significance of BAT-25 and BAT-26 instability in breast cancer among Senegalese patients

Abstract

In some tumors, defects in mismatch repair enzymes lead to errors in the replication of simple nucleotide repeat segments. This condition is commonly known as microsatellite instability (MSI) because of the frequent mutations of microsatellite sequences. The primary aim of this study is to evaluate the clinicopathological and survival significance of BAT-25 and BAT-26 instability, in 60 patients with breast cancer. Polymerase chain reaction was used to amplify the following microsatellite repeat loci BAT-25 and BAT-26. Medical records were studied in order to determine clinical data of BAT-25 and BAT-26, analysis was carried out. 60.71% of cancer tissues analyzed were found to be unstable for both markers.BAT-26 instability has an impact on the age (Od: 15.47; CI 1.08-974; 19, P: 0.020) and survival (P: 0.0342) of patients. BAT-26 which has a poly A sequence, can be considered alone as a good marker for the detection of MSI tumors in breast cancer.

MSI‐L/EMAST is a predictive biomarker for metastasis in colorectal cancer patients

“…Palombo et al (1995) and Suraweera et al (2002) all nontumor tissues (Pyatt et al, 1999) but so far, the demographic variability of these markers has not been properly reported (Buhard, Suraweera, Lectard, Duval, & Hamelin, 2004). The results in this study point to the high prevalence of BAT-25 in MSI-L/EMAST tumors, but as there are no studies using this panel, the reported incidence for this marker is not comparable with the studies used (IAP1) gene (Mbaye, Ka, Dem, Kane, Sembéne, 2015). In the present study which was conducted in Iran and evaluated MSI based on three quasimonomorphic panel 37.7% of the patients had MSI-L CRCs.…”

“…MSI‐H tumors are associated with a relatively favorable prognosis (Nojadeh, Behrouz Sharif, & Sakhinia, ) that is related to creating numerous neoantigens, which promote infiltration of cytotoxic (CD8 + ) T‐lymphocytes and activated Th1 cells to the tumor microenvironment (Yuza, Nagahashi, Watanabe, Takabe, & Wakai, ). The BAT‐25 locus is a 25(T) repeat identified in intron 16 of the c‐kit proto‐oncogene , BAT‐26 consists of 25 (A) located within the fifth intron of the MSH2 gene, whereas NR‐27 contains a repetition of 27 (A) and is located within the 5′‐untranslated region (UTR) of the inhibitor of apoptosis protein‐1 ( IAP1 ) gene (Mbaye, Ka, Dem, Kane, Sembéne, ). In the present study which was conducted in Iran and evaluated MSI based on three quasimonomorphic panel 37.7% of the patients had MSI‐L CRCs.…”