Clinicopathological and prognostic significance of galectin-1 and vascular endothelial growth factor expression in gastric cancer

Chen, Jie; Zhou, Sujun; Zhang, Yun; Zhang, Guoqiang; Zha, Tian-Zhou; Yang, Feng; Zhang, Kai

doi:10.3748/wjg.v19.i13.2073

Cited by 47 publications

(32 citation statements)

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“…In the present study, we observed that in tumor tissue samples from 127 patients with GC samples, Gal-1 is overexpressed in human GC as compared with matched nontumor tissues, which consistent with previous reports [18,34] . We also confirmed that expression of S1PR1 in human GC tissue was higher than in matched non-tumor tissue, and that expression of Gal-1 was positively correlated with S1PR1 expression in GC tissue.…”

Section: Discussionsupporting

confidence: 81%

“…Gal-1 expression is found in GC, and aberrant Gal-1 expression enhanced GC cell migration and in vitro invasion [19,20]. In the clinical setting, increased Gal-1 expression was found to be associated with poor prognosis [18].…”

Section: Introductionmentioning

confidence: 99%

“…In the extracellular environment, Gal-1 mediates cellular aggregation, promotes tumor formation, and participates in defining b-galactoside activity [11,13]. Gal-1 is altered in a variety of cancer cell types [14][15][16][17], including GC [18]. Gal-1 expression is found in GC, and aberrant Gal-1 expression enhanced GC cell migration and in vitro invasion [19,20].…”

Section: Introductionmentioning

confidence: 99%

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Galectin-1 Promotes Metastasis in Gastric Cancer Through a Sphingosine-1-Phosphate Receptor 1-Dependent Mechanism

You

Wang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Increased expression of galectin-1 (Gal-1) in gastric cancer (GC) promotes metastasis and correlates with poor prognosis. The mechanisms by which Gal-1 promotes GC metastasis remain unknown. Methods: Gal-1and Sphingosine-1-phosphate receptor 1 (S1PR1) were determined by immunohistochemistry(IHC) and quantitative real time polymerase chain reaction (qRT-PCR) in GC specimens. Stably transfected Gal-1 or S1PR1 into SGC7901 and MGC-803 cells, western blot and invasion assays in vitro and nude mice tumorigenicity in vivo were also employed. Results: Overexpression of Gal-1 enhanced expression of S1PR1 in SGC-7901 cells, and increased cell invasion, while knockdown Gal-1 in MGC-803 cells reduced S1PR1 expression and diminished invasion. Simultaneous knockdown of Gal-1 and overexpression of S1PR1 in MGC803 cells rescued invasive ability of MGC803 cells. S1PR1 was associated with expression of epithelial-to-mesenchymal transition (EMT) markers in vitro and in clinical samples. EMT induced in MGC-803 cells by TGF-β1 was accompanied by S1PR1 activation, while knockdown of S1PR1 reduced response to TGF-β1, suggest that Gal-1 promotes GC invasion by activating EMT through a S1PR1-dependent mechanism. Overexpression of S1PR1 promoted subcutaneous xenograft growth and pulmonary metastases, and enhanced expression of EMT markers. Conclusion: Galectin-1 promotes metastasis in gastric cancer through a S1PR1- dependent mechanism, our results indicate that targeting S1PR1 may be a novel strategy to treat GC metastasis.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Galectin-1 Promotes Metastasis in Gastric Cancer Through a Sphingosine-1-Phosphate Receptor 1-Dependent Mechanism

You

Wang

et al. 2018

Cell Physiol Biochem

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“…Conclusion: VM should be regarded as a good marker to indicate pathobiological behaviors of gastric cancer. Using anti-a potent multifunctional cytokine, can not only enhance the proliferation of vascular epithelial cells and inhibit their apoptosis to form the vascular structure [10], but also increase vascular permeability [11] and promote vascular leakage and invasion [12]. The 2 tyrosine kinase receptors, VEGFR1 and VEGFR2, bind to VEGF and possess different characteristics.…”

Section: Introductionmentioning

confidence: 99%

Significance of Vasculogenic Mimicry Formation in Gastric Carcinoma

Sun

et al. 2017

Oncol Res Treat

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Background: The purpose of this study was to evaluate the clinical significance and prognostic roles of vasculogenic mimicry (VM) and elucidate their intrinsic association with molecular markers. Methods: 89 human gastric cancer cases with detailed follow-up and clinicopathologic data were collected. CD34/periodic acid-Schiff double staining was performed to validate the existence of VM. Immunohistochemistry was performed to explore the expression of different molecular factors. Results: VM was observed in 24 gastric cancer patients. They were prone to higher histological grade, hematogenous metastasis, distant recurrence, and chance of progression to stage III or IV (p < 0.05). The VM group had shorter overall and disease-free survival (p < 0.05). VM negativity was independently prognostic for prolonged overall or disease-free survival (p < 0.05). VM was positively associated with levels of matrix metalloproteinase-2, matrix metalloproteinase-9, vascular endothelial growth factor, and vascular endothelial growth factor receptor-1 (p < 0.05), but not with vascular endothelial growth factor receptor-2 (p > 0.05). Conclusion: VM should be regarded as a good marker to indicate pathobiological behaviors of gastric cancer. Using antibodies against matrix metalloproteinases, vascular endothelial growth factor, or vascular endothelial growth factor receptors could be strategies to counteract VM formation.

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“…Interestingly, in most such cases, the expression correlates with the aggressiveness and metastatic phenotype of cancer. Two recent studies in gastric cancer and cervical cancer showed a positive correlation between gal-1 expression and tumour stage, tumour invasion and lymph node metastasis [31,32]. Similarly, gal-1 and gal-3 are over expressed in most cancers [33,34] and high serum levels of gal-3 in cancer correlate to higher incidence of distant metastasis [26].…”

Section: Discussionmentioning

confidence: 94%

Galectin-1 and galectin-3: Plausible tumour markers for oral squamous cell carcinoma and suitable targets for screening high-risk population

Aggarwal

Sharma

Das

2015

Clinica Chimica Acta

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Clinicopathological and prognostic significance of galectin-1 and vascular endothelial growth factor expression in gastric cancer

Abstract: Galectin-1 expression was positively associated with VEGF expression. Both galectin-1 and VEGF can serve as independent prognostic indicators of poor survival for gastric cancer after gastrectomy.

Cited by 47 publications

References 0 publications

Galectin-1 Promotes Metastasis in Gastric Cancer Through a Sphingosine-1-Phosphate Receptor 1-Dependent Mechanism

Galectin-1 Promotes Metastasis in Gastric Cancer Through a Sphingosine-1-Phosphate Receptor 1-Dependent Mechanism

Significance of Vasculogenic Mimicry Formation in Gastric Carcinoma

Galectin-1 and galectin-3: Plausible tumour markers for oral squamous cell carcinoma and suitable targets for screening high-risk population

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