Clinicopathological and immunohistochemical profile of non-small cell lung carcinoma in a tertiary care medical centre in South India

Shankar, Shanmugapriya; Thanasekaran, Vijayalakshmi; Thangaswamy, Dhanasekar; Duvooru, Prathiba

doi:10.4103/0970-2113.125889

Cited by 17 publications

(25 citation statements)

References 20 publications

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“…The mean age was 61 years. These values are comparable with study done by Shanmugapriya Shankar et al, [1] in which the peak incidence was between 61 and 70 years of age. In our study, lowest age was 42 years and highest age was 86 years.…”

Section: Table 1 Comparison Of Sex Ratio With Similar Studiessupporting

confidence: 91%

“…Shankar et al [1] M Gangopadhyay et al [3] Present Among the 80 cases of non-small cell lung carcinoma majority were squamous cell carcinoma 58.75% (47 cases), adenocarcinoma constituted 33.75% (27 out of 80 cases), adenosquamous carcinoma 3.75% (3 out of 80 cases) and NSCLC-NOS 3.75% (3 out of 80 cases). These results can be comparable with the study done by Shankar S et al in 2014.…”

Section: Shanmugapriyamentioning

confidence: 99%

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The Role of Immunohistochemical Markers (P63 and TTF-1) in the Diagnosis and Classification of Non-Small Cell Lung Carcinoma

Savithamol¹,

Letha²,

Sankar³

2018

jemds

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BACKGROUND Lung carcinoma is the most common cause of cancer mortality worldwide. Most non-small cell lung carcinomas are inoperable and histologic diagnosis made on small biopsy samples are prone to diagnostic inaccuracy. So, precise subtyping of poorly differentiated non-small cell lung carcinoma (NSCLC) into adenocarcinoma and squamous cell carcinoma has a direct impact on management of patient and prognosis. The aim of this study was to investigate the role of immunohistochemistry profile using p63 and TTF-1 for differentiating nonsmall cell lung carcinoma into squamous cell carcinoma and adenocarcinoma. MATERIALS AND METHODS This descriptive study was conducted to assess p63 and TTF-1 expression in 80 cases of non-small cell lung carcinoma received in the Department of Pathology, Government Medical College, Kottayam during a period of 18 months (March 2016-September 2017). RESULTS Present study includes 80 cases of histologically diagnosed NSCLC. Of the study population, 73 cases (91.25%) were males and 7 cases (8.75%) were females. Among males, squamous cell carcinoma is the predominant histological subtype and adenocarcinoma is the predominant subtype in females. In this study, peak incidence is between 60-69 years of age. The mean age is 61 years. Out of the 80 histologically diagnosed cases of NSCLC studied, after IHC confirmation 47 were squamous cell carcinoma (58.75%), 27 were adenocarcinoma (38.75%), 3 were adenosquamous (3.75%) and rest 3 were NSCLC-NOS (3.75%). Histologically diagnosed cases of squamous cell carcinoma show 100% positivity for p63 and adenocarcinoma shows 100% positivity for TTF-1. CONCLUSION Both p63 and TTF-1 have 100% expression in squamous cell carcinoma and adenocarcinoma respectively. Hence, these markers may be recommended for subtyping of poorly differentiated non-small cell lung carcinoma (NSCLC).

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Section: Table 1 Comparison Of Sex Ratio With Similar Studiessupporting

confidence: 91%

Section: Shanmugapriyamentioning

confidence: 99%

The Role of Immunohistochemical Markers (P63 and TTF-1) in the Diagnosis and Classification of Non-Small Cell Lung Carcinoma

Savithamol¹,

Letha²,

Sankar³

2018

jemds

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“…Similar observation has been reported by other Indian studies also [6][7][8][9]. The prevalence of respiratory system malignancies is quite variable in different parts of India.…”

Section: Discussionsupporting

confidence: 78%

“…Progressive survival extension and increasing cigarette smoking have led to a numerical rise of patients with primary lung cancer in India. It is in accordance with the epidemiological data from western countries, which shows rising prevalence of the disease in Indian population [2]. Smoking is the cause of more than 85% of the bronchogenic carcinoma cases.…”

Section: Introductionsupporting

confidence: 67%

Clinico-pathological profile of lung cancer in North Indian population

Bhaskar

Singh

et al. 2018

IJRDPL

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Lung cancer is the most common cancer representing approximately 12% of all new cancers. It is also the most frequent type of cancer in males and remains the most a common cause of cancer-related mortality in both sexes. An increasing incidence of lung cancer has been observed in India. We studied the clinical and pathological profile of patients with lung cancer in a tertiary care center. We performed a retrospective analysis of histopathologically proven cases of bronchogenic carcinoma admitted in our hospital. In our study we included 203 patients with confirmed cases of lung cancer. Male to female ratio was 8.2:1. The common age group being 40-60 years, 9.86% of the patients were less than 40 years old age. Smoking was found to be the main risk factor for 81.77% patients. The most frequent symptom was a cough (72.90%) followed by fever (58.12%). The most common radiological presentation was mess lesion (46.31%). The most common histopathological type was squamous cell carcinoma (SCC) (44.83%) followed by adenocarcinoma (19.78%) and small cell lung carcinoma (SCLC) (16.75%). The majority patients (73.29%) were diagnosed in the later stages of the disease (3b and 4). Squamous cell carcinoma was the most frequent histopathological form. Smoking remains the major risk factor for lung cancer.

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“…4 Non-Small Cell Lung Carcinoma accounts for 80-85% of all lung carcinomas and adenocarcinoma is the predominant histologic type with male preponderance. 4 Nowadays incidence of Adenocarcinoma lung is increasing in women and non-smokers. Our patient presented with large mass involving entire right hemi-thorax at a young age.…”

Section: Discussionmentioning

confidence: 99%

A Case of Concomitant Adenocarcinoma of Lung and Pulmonary Tuberculosis in a Young Female

Pujari¹,

Shraddha²,

B³

2014

jemds

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28 year female presented to us with X-ray chest suggestive of right opaque hemithorax. She was on anti-tubercular treatment for the presence of Acid Fast Bacilli (AFB) in pleural fluid. Clinical examination revealed bronchial breathing on right side. CT thorax showed large mass lesion in right hemi thorax with mild pleural effusion. Thoracocentesis and bronchoscopy showed no evidence of malignancy however AFB were detected in bronchial washing. Transthoracic biopsy was positive for malignancy. On Immunohistochemistry (IHC), Thyroid Transcription Factor 1(TTF1) and NAPSIN A were positive, confirming the diagnosis of adenocarcinoma lung. Final diagnosis of primary adenocarcinoma lung with concomitant tuberculosis was established.

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Clinicopathological and immunohistochemical profile of non-small cell lung carcinoma in a tertiary care medical centre in South India

Cited by 17 publications

References 20 publications

The Role of Immunohistochemical Markers (P63 and TTF-1) in the Diagnosis and Classification of Non-Small Cell Lung Carcinoma

The Role of Immunohistochemical Markers (P63 and TTF-1) in the Diagnosis and Classification of Non-Small Cell Lung Carcinoma

Clinico-pathological profile of lung cancer in North Indian population

A Case of Concomitant Adenocarcinoma of Lung and Pulmonary Tuberculosis in a Young Female

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