Clinicopathologic study of large cell anaplastic lymphoma (ki-1-positive large cell lymphoma) among the japanese

Nakamura, Shigeo; Takagi, Norio; Kitoh, Kuniyoshi; Suchi, Taizan; Kojima, Masaru; Motoori, Tadashi; Osada, Hiroyuki; Takahashi, Toshitada; Suzuki, Hisamitsu; Ogura, Michinori; Kurita, Soji; Oyama, Atsushi; Ueda, Ryuzo

doi:10.1002/1097-0142(19910701)68:1<118::aid-cncr2820680123>3.0.co;2-r

Cited by 85 publications

(31 citation statements)

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“…Group A showed a poor prognosis compared with groups B and C. 13 The anaplastic large cell lymphoma (ALC) usualy show favourable clinical behaviour, between Hodgkin's disease and low-grade T-cell lymphoma. 24 However, we have also reported that anaplastic large cell lymphoma with HTLV-I integration is associated with a poor prognosis compared with ALC without HTLV-I antibody. 9 In the present study, to clarify the clinicopathological features of HTLV-I-associated lymphadenopathy, group A was further classified into three morphological subgroups: pleomorphic (medium and large cell) type, pleomorphic small cell type, and anaplastic large cell type (ALC).…”

Section: Discussionmentioning

confidence: 86%

Survival of patients with HTLV-I-associated lymph node lesions

et al. 1999

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Adult T‐cell leukaemia/lymphoma (ATLL), is a malignant condition associated with human T‐cell leukaemia virus type I (HTLV‐I). Usually, although not uniformly, histopathological examination of the lymph nodes shows a pleomorphic type. In addition, some patients with pre‐overt ATLL show a Hodgkin's disease‐like morphology and lymph nodes in non‐neoplastic carriers show features of lymphadenitis. To characterize further the clinicopathological features of HTLV‐I‐associated lymphadenopathy, the histopathological features of the lymph nodes of 289 patients were classified into five types: lymphadenitis ( n=14), Hodgkin's‐like (Hodgkin's) ( n=18), pleomorphic (medium and large cells) ( n=219), pleomorphic small cell ( n=11), and anaplastic large cell (ALC) ( n=27). Survival data were analysed according to the histopathological features of the lymph nodes. The pleomorphic type, which showed typical features of ATLL, was associated with a highly aggressive course and an initially high mortality, followed by a rapid decrease in survival. This pattern was also observed in patients with the ALC type. All cases with lymphadenitis were still alive at the end of the study, while survival progressively decreased in the Hodgkin's type. The small cell type showed an initial rapid decrease in survival followed by a plateau. These results show that the survival trends of patients with pleomorphic and anaplastic lymph node lesions are similar to those with ATL lymphoma, while patients with the lymphadenitis type of lesion were considered to have a non‐neoplatic status. There is at present no effective therapy for ATLL, but in the future, these classification and survival data might be useful for the selection of appropriate chemotherapeutic regimens for patients with ATLL. Copyright © 1999 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 86%

Survival of patients with HTLV-I-associated lymph node lesions

et al. 1999

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“…With the exception of ALCL, cytotoxic lymphomas are usually extranodal and show an aggressive clinical course [12,22,30]. On the other hand, ALCL show a favourable clinical behaviour, somewhere between those of Hodgkin disease and low-grade T-cell lymphoma [33]. As an example of extranodal T-cell lymphomas, intestinal Tcell lymphoma (ITCL) is an uncommon entity.…”

Section: Discussionmentioning

confidence: 99%

Clinical, immunohistochemical and phenotypic features of aggressive nodal cytotoxic lymphomas, including α/β, γ/δ T-cell and natural killer cell types

et al. 1999

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Cytotoxic cells include natural killer (NK) cells and cytotoxic alpha beta and gamma delta T lymphocytes (CTLs). These cells express cytotoxic molecules of T-cell restricted intracellular antigen (TIA-1), and activated cytotoxic molecules of perforin, granzyme B, and FasL. Recent studies suggest that most extranodal T-cell lymphomas are derived from CTLs, and that NK cell lymphomas are extranodal. However, only a few nodal NK and cytotoxic lymphomas have been described so far. We present here the clinicopathological features of seven cases of nodal cytotoxic T and NK cell lymphomas. The study excluded anaplastic large-cell lymphomas expressing cytotoxic molecules. The neoplastic cells of all cases contained activated cytotoxic molecules of TIA-1, granzyme B, Fas ligand, and/or perforin. Phenotypically and genotypically, four cases showed alpha beta T cell type [CD2+, CD3+, T-cell receptor (TCR)-delta-1-, beta F1+, and TCR gene rearrangement], two cases showed gamma delta cell type [CD2+, CD3+, T-cell receptor (TCR) delta-1+, beta F1-, and TCR gene rearrangement], and one case showed NK cell type [CD2+, CD3-, CD56+, T-cell receptor (TCR) delta-1-, beta F1-, and TCR gene germline]. Using Southern blot analysis, Epstein-Barr virus (EBV) sequences were detected in six cases, and monoclonal terminal repeat proliferation was confirmed. In addition, in situ hybridization (ISH) studies for EBV showed EBV infection in almost all neoplastic cells. Clinically, all patients presented with peripheral lymphadenopathy in high clinical stages and showed an aggressive course. Hepatosplenomegaly was detected in six cases. During the course of the disease, bone marrow and extranodal invasion were noted in five cases. The nodal type showed an aggressive clinical course in all cases but one, as did the extranodal type. The nodal type varied in phenotype, but was closely associated with EBV infection.

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“…Despite the anaplastic morphology, Ki-1 ALCL may have a better prognosis than other high-grade lymphomas [16][17][18][19] . In the cases we describe three of seven patients in whom adequate clinical details were available had an advanced stage (III or IV) at presentation.…”

Section: Discussionmentioning

confidence: 99%