Clinicopathologic Review of Non-Myxoma Cardiac Tumors: A 10-Year Single-Center Experience

Abstract

Objective: To report the prevalence, clinical presentation and histological characteristics of non-myxoma cardiac tumors in a major tertiary heart center. Method: Review of the medical profiles of 36,930 patients admitted to our hospital between 2003 and 2013 yielded a total of 86 cases of cardiac tumors (63 cases of myxomas and 23 cases of non-myxoma tumors). Clinical presentations and histological features were presented exclusively for primary and secondary tumors. Results: Of 23 enrolled patients with non-myxoma tumors, 5 had primary tumors and 18 had secondary or metastatic tumors. The most frequent origins of the secondary tumors were breast cancer, lymphoma, leukemia and lung cancer. Most secondary tumors had pericardial involvement, and only one tumor involved the left atrium. Sarcomas, including spindle-cell sarcoma and liposarcoma, comprised the majority of the primary malignant tumors. None of these tumors had pericardial involvement, and, except for one case, all were confined to the left side of the heart. All patients were symptomatic on admission, with dyspnea being the most frequent presenting symptom. Conclusion: Metastatic cardiac tumors were more prevalent than the primary ones, with fibromas constituting the largest proportion of the primary tumors and breast cancer being the prevalent cause of metastasis.

Incremental value of PET and MRI in the evaluation of cardiovascular abnormalities

“…Secondary tumours are significantly more common than primary tumours [ 13 ]. Myxoma is the most common primary tumour in the heart [ 14 ]. The role of imaging is (1) to characterize the mass, since it determines treatment strategy; (2) determine local staging, including extent of the tumour and involvement of adjacent structures, which is essential for surgical mapping; (3) to determine if chemo- or radiotherapy is required along with surgery; and (4) to assess response to therapy [ 15 ].…”

The Tactics of Safe Removal of Heart Myxomas; The Experience of 796 Operations

“…Frequency of diagnostics of primary heart tumors (from which more than 80% are morphologically of benign tumours) in relation to the acquired heart diseases makes from 1,5% to 2 %, or from 0,09% to 1,9% from the incurrence of the hospitalized patients. (1,2) Clinical displays come to light mainly in the late stages of disease, in addition, a prognosis at this pathology remains unfavorable. (1,2) Questions of diagnostics of new formations of heart and their adequate, quite often urgent surgical treatment are actual.…”

“…(1,2) Clinical displays come to light mainly in the late stages of disease, in addition, a prognosis at this pathology remains unfavorable. (1,2) Questions of diagnostics of new formations of heart and their adequate, quite often urgent surgical treatment are actual. (3,5) Purpose of the research -to determine the peculiarities of diagnostics and to search the tactics of optimal and the safe surgical treatment of myxoma of the heart.…”

Особливості Тактики Хірургічного Лікування Первинних Доброякісних Пухлин Серця

“…У структурі серцевих новоутворювань міксоми становлять 80-90% доброякісних пухлин серця. Частота діагностики ППС, з яких понад 80% є морфологічно доброякісними пухлинами, становить від 0,09% до 1,9% до загального числа госпіталізованих хворих [1,2]. Клінічні прояви виявляються переважно на пізніх стадіях захворювання, крім того, без хірургічного лікування прогноз при цій патології залишається несприятливим.…”