Clinicopathologic features and outcomes of gastrointestinal stromal tumors arising from the esophagus and gastroesophageal junction

Briggler, Andrew M.; Graham, Rondell P.; Westin, Gustavo Figueiredo Marcondes; Folpe, Andrew L.; Jaroszewski, Dawn E.; Okuno, Scott H.; Halfdanarson, Thorvardur R.

doi:10.21037/jgo.2018.04.06

Cited by 11 publications

(8 citation statements)

References 44 publications

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“…GISTs são tumores que, na maioria das vezes, possuem como receptor a proteína tirosina-quinase CD117, produzida pelo proto-oncogene c-KIT. A mutação no gene KIT supracitada está presente em 75 a 95% dos casos de GIST e, assim sendo, é recomendada a pesquisa dessa mutação quando há incerteza acerca do diagnóstico 1,4,8,11 .…”

Section: Discussionunclassified

“…Sobre o tratamento cirúrgico, geralmente, a enucleação é realizada quando o tumor mede menos de 5cm, enquanto a esofagectomia é indicada em tumores maiores que 9cm. Dado que o tumor excedia 9cm, foi optado pela esofagectomia como tratamento, sem retirada de linfonodos na proximidade do tumor e continuidade do tratamento com imatinibe [5][6][7][8] .…”

Section: Discussionunclassified

“…Não há atualmente nenhuma menção de GIST esofágico nos esquemas para estratificação de risco e é difícil definir prognóstico 8 .…”

Section: Introductionunclassified

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Tumor Estromal Esofágico: Relato De Caso E Revisão De Literatura

Maffini¹,

De-Lucca²,

Antunes³

et al. 2021

Relatos Casos Cir.

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Introdução: Os tumores estromais gastrointestinais (GIST) correspondem a 1% dos tumores do trato gastrointestinal e sua localização esofágica é ainda mais rara. Dada sua baixa incidência, não há recomendações claras acerca do manejo da doença. Relato do caso: Mulher, 50 anos, portadora de GIST esofágico, com quadro clínico de disfagia. A biópsia demonstrou a presença do tumor de esôfago não metastático, positivo para CD117. O tratamento de escolha foi esofagectomia total, reconstrução com estômago seguida de jejunostomia, seguido de terapia adjuvante com imatinibe. Cerca de um ano após início de quimioterapia, paciente apresenta-se sem recorrências e metástase, no entanto desenvolveu uma neuropatia periférica. Conclusão: Trata-se de um caso de GIST raro pela sua localização esofágica, tratado com sucesso. Além disso, a paciente desenvolveu neuropatia periférica, possivelmente causada pelo uso do quimioterápico.

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Section: Discussionunclassified

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Tumor Estromal Esofágico: Relato De Caso E Revisão De Literatura

Maffini¹,

De-Lucca²,

Antunes³

et al. 2021

Relatos Casos Cir.

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“…Proximal gastric stromal tumors may cause difficulty in swallowing, while tumors located in the pylorus may present as a gastric outlet obstruction (2,3). At initial diagnosis, ~20% of patients present with metastases (4), which typically occur in the abdominal cavity or liver, whereas lung, bone or brain metastases are rare.…”

Section: Clinical Significance Of the Molecular Heterogeneity Of Gastmentioning

confidence: 99%

Clinical significance of the molecular heterogeneity of gastrointestinal stromal tumors and related research: A systematic review

Ding

et al. 2020

Oncol Rep

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Gastrointestinal stromal tumors (GISTs) are the most commonly observed mesenchymal tumors of the digestive tract, and they originate from the interstitial cells of Cajal. GISTs can be divided into KIT/PDGFRA-mutant GISTs and wild-type GISTs based on the presence or absence of KIT/PDGFRA mutations. Wild-type GISTs can be divided into succinate dehydrogenase complex (SDH)-deficient GISTs and non-SDH-deficient GISTs. Downstream signaling pathways activated by these mutations serve a pivotal role in the development of GISTs and are associated with the biological behavior, including risk stratification, clinical prognosis and drug resistance. Accurate medical care requires accurate molecular diagnosis, which in turn prolongs the survival of patients with GISTs and makes GIST a chronic disease. At present, there is a lack of effective treatment for imatinib/sunitinib/regorafenib resistant patients and KIT/PDGFRA-WT GISTs, which is undoubtedly a major challenge for future research. The present review summarizes the molecular pathogenesis of GISTs and the progress of related research.

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“…Other symptoms include melena, hematemesis, fullness, and palpable mass. GISTs that are located in the proximal stomach may lead to dysphagia, while tumors located in the pylorus may present as gastric outlet obstruction [ 9 , 10 ]. GISTs can be a part of a syndrome called Carney's triad (gastric GIST, pulmonary chondroma, and paraganglioma) or neurofibromatosis type 1 (mostly spindle cell GIST) [ 11 ].…”

Section: Clinical Presentation Imaging and Pathological Diagnosimentioning

confidence: 99%

Clinical Overview of GIST and Its Latest Management by Endoscopic Resection in Upper GI: A Literature Review

Marcella

Shi

Sarwar

2018

Gastroenterology Research and Practice

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Aims To review the clinical presentation, diagnosis, assessment of risk of malignancy, and recent advances in management (mainly focusing on the role of endoscopic resection) of gastrointestinal stromal tumors (GISTs) in upper GI. Method We searched Embase, Web of science, and PubMed databases from 1993 to 2018 by using the following keywords: “gastrointestinal stromal tumors,” “GIST,” “treatment,” and “diagnosis.” Additional papers were searched manually from references of the related articles. Findings The improvement of endoscopic techniques in treating upper gastrointestinal subepithelial tumors especially gastrointestinal tumors has reduced the need for invasive surgery in patients unfit for surgery. Many studies have concluded that modified endoscopic treatments are effective and safe. These treatments permit minimal tissue resection, better dissection control, and high rates of en bloc resection with an acceptable rate of complications.

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Clinicopathologic features and outcomes of gastrointestinal stromal tumors arising from the esophagus and gastroesophageal junction

Abstract: Among esophageal and GEJ GISTs, metastatic disease was associated with increased mitotic count and increased tumor size. Men were found to have inferior OS. The Joensuu risk criteria were validated for risk stratification of esophageal and GEJ GISTs.

Cited by 11 publications

References 44 publications

Tumor Estromal Esofágico: Relato De Caso E Revisão De Literatura

Tumor Estromal Esofágico: Relato De Caso E Revisão De Literatura

Clinical significance of the molecular heterogeneity of gastrointestinal stromal tumors and related research: A systematic review

Clinical Overview of GIST and Its Latest Management by Endoscopic Resection in Upper GI: A Literature Review

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