Clinicopathologic conference: Multiquadrant expansile fibro-osseous lesion in a juvenile

Kumar, Vijaya; Ebenezer, Supriya; Narayan, TV; Wagner, Wilfried

doi:10.1016/j.tripleo.2011.08.021

Cited by 11 publications

(13 citation statements)

References 17 publications

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“… 12 Some indicated that active treatment is not always necessary, whereas trimming of the affected bone might be necessary from a cosmetic perspective. 13 Benign as FGC appears from a pathologic perspective, caution and vigilance should be given to treatment since a conservative approach, such as surgical trimming and contouring, will more often than not lead to local recurrence and stimulation of tumor growth, as is presented in our patient. Therefore, we agree with Noffke et al 14 and Finical 15 in resorting to a complete resection of FGC with curative purposes whenever feasible.…”

Section: Discussionmentioning

confidence: 71%

Familial Gigantiform Cementoma

Wang

et al. 2016

Medicine

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Familial gigantiform cementoma is an exceedingly rare but distinct subtype of cemento-osseous-fibrous lesion. Undocumented radiographic changes and related bone metabolism disorder are herein hypothesized and discussed.We present an adolescent case with recurrent familial gigantiform cementoma who received surgical intervention in our hospital. Apart from typical multiquadrant and expansile abnormalies involving both jaws, he also suffered from several times of fractures in lower extremity. Furthermore, radiographic examinations of calvaria, pelvis, femoris, tibia, and fibula all revealed radiolucent areas signifying diffuse osteopenic bone losses. Some of his consanguineous relatives bore the same burden of fractures during pubertal period.Considering these polyostotic conditions, a correlation of congenital bone metabolism disorder in cases with familial gigantiform cementoma, named “calcium steal disorder,” was thus proposed.Familial gigantiform cementoma is closely associated with “calcium steal disorder.” Whole-body dual-energy absorptiometry should be considered as a routine examination for fracture-related risk prediction.

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Section: Discussionmentioning

confidence: 71%

Familial Gigantiform Cementoma

Wang

et al. 2016

Medicine

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“…The GC is a rare fibro‐osseous entity, histologically similar to other fibro‐osseous lesions, that typically presents as massive multifocal and multiquadrant lesions. The lesions tend to arise during childhood and progressively expand to cause facial deformity during the early adult years. Rapid expansion of the jaws often occurs in adolescence, resulting in tooth impaction, malposition and malocclusion.…”

Section: Discussionmentioning

confidence: 99%

“…Although many cases of GC have been reported in whites, GCs have been reported in a variety of ethnic groups and has an equal gender distribution. Radiographically, GC is characterised by multiple, circumscribed mixed radiolucent‐radiopaque lesions in the mandible and maxilla, which may involve two, three or four quadrants of the jaws. In the earliest stages of GC, and some familial cases, the lesions may radiographically resemble FlCOD.…”

Section: Discussionmentioning

confidence: 99%

“…Early lesions can appear as radiolucencies in the periapical regions of the teeth, with minimal bony expansion, and/or as focal radiopacities with a radiolucent space surrounding the opacity. The lesions progress to replace the normal bone, eventually resulting in a large radiolucent mass with floccules of calcification. In familial cases, this variability in radiographic pattern is likely due to incomplete penetrance/expressivity.…”

Section: Discussionmentioning

confidence: 99%

“…The lesions of GC have an onset at a young age, may develop rapidly and often involve all four jaw quadrants. The lesions tend to occur in families and appear to be inherited in an autosomal dominant pattern, with variable phenotypes, although sporadic cases have been reported. GC belongs to a group of diseases known as benign fibro‐osseous lesions, as histologically, they are composed of variable quantities of fibrous and calcified tissues.…”

Section: Introductionmentioning

confidence: 99%

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Gigantiform cementoma of the mandible: case report and literature review

et al. 2014

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The gigantiform cementoma (GC) is an extremely rare, benign condition of fibro-cemento-osseous origin that is noted in the jaws, more commonly in younger individuals. Both sporadic cases of GC and those with an autosomal dominant pattern of inheritance have been reported in the English literature. There exists a great deal of overlap and confusion between GC and other benign, reactive or neoplastic fibro-osseous lesions, especially florid cement-osseous dysplasia and ossifying fibroma. The GC typically presents as a multiquadrant, expansile, mixed radiolucent-opaque lesions that frequently cross the midline of the jaws. We report a case of GC in a 41-year-old Haitian female. Clinical, radiographic, and microscopic features of this condition are presented, along with criteria to differentiate GC from other fibro-osseous diseases of the jaws. A brief review of the literature with clinical, radiographic findings and treatment recommendation is discussed. Additional cases of GC, as well as further investigation of the genes that may be involved, are needed to further understand this rare entity.

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