Clinicopathologic characteristics of cutaneous chronic graft‐versus‐host diseases: a retrospective study in Korean patients

Kim, Sun-Ji; Choi, Jung‐Min; Kim, Jung-Eun; Cho, Baik‐Kee; Kim, Dong Wook; Park, Hyun-Jeong

doi:10.1111/j.1365-4632.2010.04552.x

Cited by 26 publications

(21 citation statements)

References 23 publications

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“…19 The two cases herein presented were, in some way, morphologically related with the keratosis pilaris-like lesions reported by Kim et al 7 They described perifollicular erythema with papules or follicular keratosis and spiny protrusion, although they did not report comedones. 7 Histopathologically, the most similar case to those here described was reported by Shin et al 20 They described an acute follicular GVHD with two cutaneous nodules although unfortunately no clinical pictures illustrated the lesions. A skin biopsy showed dilated follicular infundibula with necrotic keratinocytes, vacuolar degeneration along the basal layer of infundibular epithelium and some pigment incontinence, thus resembling a comedo.…”

Section: Discussionsupporting

confidence: 45%

“…1 Some uncommon reported histopathologic variants include lesions mimicking hemangiomas, 4 the presence of keratinocyte-derived amyloidosis, 5 mucin deposition, 6 acanthosis nigricans-like lesions 7 a prominent epithelial follicular infundibular epithelial hyperplasia mimicking hypertrophic lupus erythematosus 8 or erythema multiformelike lesion. 9,7 Often, clinicopathological correlation is needed for a correct diagnosis because similar histopathologic findings may be found in different variants with a different prognosis like eczematoid 10 and atopic dermatitis-like GVHD. 11 On the other hand, cutaneous involvement has been classically classified into limited and extensive forms.…”

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confidence: 98%

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Comedonal graft‐vs‐host disease: a distinct clinical expression of a lichenoid follicular GVHD

et al. 2014

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We report two cases of chronic follicular graft-vs-host disease (GVHD) that resemble closed and open acne-like comedones. We propose the term 'comedonal GVHD' for this variant. A 47-year-old man presented with multiple 2-4-mm acne-like follicular papules in facial areas on day 82 status post bone marrow transplantation. A biopsy showed follicular infundibular dilation with keratotic plugs, hypergranulosis and vacuolar alteration (hydropic degeneration) of the basal layer, with dyskeratotic (apoptotic) keratinocytes, scattered lymphocytes and vascular ectasia of the superficial dermal plexus. We diagnosed chronic follicular lichenoid GVHD. The second patient was a 53-year-old female. On day 420 after transplantation, she presented with generalized dark to grayish, confluent, indurated lesions with confluent papules and unevenly distributed comedo-like lesions. Skin biopsy showed sclerotic dermis and also dilated follicular infundibula with keratotic plugging, hypergranulosis and vacuolar alteration (hydropic degeneration) of the basal layer of the epidermis. We established the diagnosis of chronic sclerodermoid GVHD with follicular lichenoid involvement. The presence of open and closed comedones on the trunk and facial region of an adult raises several differential diagnosis but in our patients, histopathologic study demonstrated typical features of GVHD, which led to this diagnoses despite the peculiar clinical findings.

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Section: Discussionsupporting

confidence: 45%

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confidence: 98%

Comedonal graft‐vs‐host disease: a distinct clinical expression of a lichenoid follicular GVHD

et al. 2014

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“…42 GVHD in particular is a major etiological factor in cutaneous manifestations, as skin is affected in almost all patients with GVHD. 43 In the current study, patient-assessed dry skin was very common, 72%, among the long-term survivors of HSCT. In addition, vast majority of the HSCT recipients (84%) demonstrated two or more subjective sicca symptoms (dry skin, dry eyes or dry mouth).…”

Section: Discussionmentioning

confidence: 99%

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Daikeler

Mauramo

Rovó

et al. 2013

Bone Marrow Transplant

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The objective of this prospective cross-sectional case-control study was to examine the prevalence of dryness symptoms and its impact on quality of life (QoL) among very long-term survivors after hematopoietic SCT (HSCT) in comparison with their respective sibling donors. Forty-four allogeneic HSCT recipients with a long-term survival (median: 17.5; range: 11-26 years) were included. Their respective, HLA-identical sibling donors served as controls. Clinical examinations included saliva flow rates (SFR) and the Schirmer's test. The presence of sicca symptoms of mouth, eyes and skin were inquired. The social functioning (SF)-36 questionnaire was applied. Recipients had lower (Po0.01) unstimulated and stimulated mean SFR than donors. Schirmer's test results o5 mm was found in 45% of the recipients in comparison with 27% of the donors (P ¼ 0.07). Xerostomia (34 vs 4 subjects), xerophtalmia (23 vs 3) and dry skin (32 vs 12) were reported more often by the recipients than donors (Po0.001). Sicca symptoms and their objective findings correlated with QoL. The mean SF-36 scores of the donors were significantly higher than those of the recipients for physical component summary. In conclusion, sicca symptoms are common amongst long-term survivors of HSCT and affect remarkably the QoL.

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“…Cutaneous involvement of cGVHD presents varied features from lichenoid to sclerodermoid changes that some clinicians may find difficult to accurately diagnose, particularly when the cGVHD mimics other disease processes. Psoriatic eruptions of this disease are particularly rare, with fewer than 6 cases presented in the literature . There have also been reports of both the development and the remission of psoriasis itself following stem cell transplant, further obfuscating delineation and the clinical diagnosis .…”

Section: Introductionmentioning

confidence: 99%

Psoriasiform graft‐versus‐host disease distributed along Blaschko's lines

et al. 2017

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This case presents an unusual manifestation of cutaneous chronic graft-vs-host disease (cGVHD) mimicking psoriasis along Blaschko's lines. Such a presentation may pose a particular challenge to providers as it is quite rarely reported, and, therefore, it is possibly misdiagnosed. cGVHD may mimic psoriasis and should be considered in any patient previously transplanted even with a previous history of psoriasis. A Blaschkoid pattern of cGVHD is unusual and may be the manifestation of an immune reaction unveiling a previously masked mosaicism.

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Clinicopathologic characteristics of cutaneous chronic graft‐versus‐host diseases: a retrospective study in Korean patients

Abstract: We report a large study about cutaneous cGVHD in Asian patients. Cutaneous cGVHD presented with a wide spectrum of clinical and histological manifestations.

Cited by 26 publications

References 23 publications

Comedonal graft‐vs‐host disease: a distinct clinical expression of a lichenoid follicular GVHD

Comedonal graft‐vs‐host disease: a distinct clinical expression of a lichenoid follicular GVHD

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Psoriasiform graft‐versus‐host disease distributed along Blaschko's lines

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