Clinicopathologic Characteristics and Surgical Treatment of Plurihormonal Pituitary Adenomas

Aydın, Seçkin; Çomunoğlu, Nil; Ahmedov, Merdin Lyutviev; Korkmaz, Özge Polat; Öz, Büğe; Kadıoğlu, Pınar; Gazioğlu, Nurperi; Tanrıöver, Necmettin

doi:10.1016/j.wneu.2019.06.217

Cited by 11 publications

(9 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plurihormonal adenomas are considered as more invasive (higher Ki-67 indices) and more prone to early recurrences than monohormonal adenomas (34)(35)(36)(37). In our study, plurihormonal prolactinomas were larger but not more invasive than lactotroph tumors.…”

Section: Discussionsupporting

confidence: 42%

Prolactinomas: Prognostic Factors of Early Remission After Transsphenoidal Surgery

Zieliński

Ozdarski²,

Maksymowicz

et al. 2020

Front. Endocrinol.

View full text Add to dashboard Cite

Results: Of 48 patients, 38 (79%) achieved early biochemical remission at 3 months. Patients in early remission at 3 months had lower serum prolactin concentrations on the first postoperative day than patients with recurrent or persistent hyperprolactinemia (p < 0.001). Using univariate logistic regression, larger maximum tumor diameter (p = 0.014), higher Knosp grade (p < 0.001), and plurihormonality predicted remission at 3 months (p = 0.021). However, using multivariate stepwise logistic regression, only the Knosp grade remained significant (p < 0.001). Conclusions: Radiological assessment of prolactinoma invasiveness (Knosp grades) and early postoperative serum prolactin concentrations are important predictors of early remission following transsphenoidal prolactinoma resection.

show abstract

Section: Discussionsupporting

confidence: 42%

Prolactinomas: Prognostic Factors of Early Remission After Transsphenoidal Surgery

Zieliński

Ozdarski²,

Maksymowicz

et al. 2020

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…The most common IHC combinations in PAWUC include GH, PRL, and one or more glycoprotein hormone subunits (β-TSH, β-FSH, β-LH, and α subunit). 29 In concordance with our findings, Aydin et al 28 found the combination of PIT1 and TFGA to be the most common subtype.…”

Section: Pit1-positive Adenomas Versus Pawucsupporting

confidence: 92%

“…In contrast to PIT1-only-positive plurihormonal adenomas, little is known about the subgroup of PAWUC. In a recently published retrospective cohort analysis, Aydin et al reported PAWUC with a rate of 2.7% of all pituitary adenomas, 28 in contrast to 4.8% in our series. The most common IHC combinations in PAWUC include GH, PRL, and one or more glycoprotein hormone subunits (β-TSH, β-FSH, β-LH, and α subunit).…”

Section: Pit1-positive Adenomas Versus Pawuccontrasting

confidence: 87%

Expression of additional transcription factors is of prognostic value for aggressive behavior of pituitary adenomas

Micko¹,

Rötzer²,

Höftberger³

et al. 2021

Journal of Neurosurgery

View full text Add to dashboard Cite

OBJECTIVEAccording to the latest WHO classification of tumors of endocrine organs in 2017, plurihormonal adenomas are subclassified by their transcription factor (TF) expression. In the group of plurihormonal adenomas with unusual immunohistochemical combinations (PAWUC), the authors identified a large fraction of adenomas expressing TFs for gonadotroph adenoma (TFGA) cells in addition to other TFs. The aim of this study was to compare clinicopathological parameters of PAWUC with TFGA expression to gonadotroph adenomas that only express TFGA.METHODSThis retrospective single-center series comprises 73 patients with TFGA-positive pituitary adenomas (SF1, GATA3, estrogen receptor α): 22 PAWUC with TFGA (TFGA-plus group) and 51 with TFGA expression only (TFGA-only group). Patient characteristics, outcome parameters, rate of invasiveness (assessed by direct endoscopic inspection), and MIB1 and MGMT status were compared between groups.RESULTSPatients in the TFGA-plus group were significantly younger than patients in the TFGA-only group (age 46 vs 56 years, respectively; p = 0.007). In the TFGA-only group, pituitary adenomas were significantly larger (diameter 25 vs 18.3 mm, p = 0.002). Intraoperatively, signs of invasiveness were significantly more common in the TFGA-plus group than in the TFGA-only group (50% vs 16%, p = 0.002). Gross-total resection was significantly lower in the nonfunctioning TFGA-plus group than in the TFGA-only group (44% vs 86%, p = 0.004). MIB1 and MGMT status showed no significant difference between groups.CONCLUSIONSThese data suggest a more aggressive behavior of TFGA-positive adenomas if an additional TF is expressed within the tumor cells. Shorter radiographic surveillance and earlier consideration for retreatment should be recommended in these adenoma types.

show abstract

“…In fact, it is impossible to completely remove a primary lesion that has extensive local invasiveness. Consequently, patients with invasive PAs generally suffer a high risk of relapse and poor outcome after surgery (Aydin et al, 2019). Currently, although NMR and postoperative pathological reports are a diagnostic basis for invasive and aggressive PAs, it was not enough to depend on the image and morphological changes to determine characteristics of PAs with invasion or noninvasion (Sav et al, 2015).…”

Section: Quantitative Proteomics Of Invasive Versus Noninvasive Pasmentioning

confidence: 99%

The use of mass spectrometry in a proteome‐centered multiomics study of human pituitary adenomas

Desiderio

Zhan

2021

Mass Spectrometry Reviews

View full text Add to dashboard Cite

A pituitary adenoma (PA) is a common intracranial neoplasm, and is a complex, chronic, and whole-body disease with multicausing factors, multiprocesses, and multiconsequences. It is very difficult to clarify molecular mechanism and treat PAs from the single-factor strategy model. The rapid development of multiomics and systems biology changed the paradigms from a traditional single-factor strategy to a multiparameter systematic strategy for effective management of PAs.A series of molecular alterations at the genome, transcriptome, proteome, peptidome, metabolome, and radiome levels are involved in pituitary tumorigenesis, and mutually associate into a complex molecular network system. Also, the center of multiomics is moving from structural genomics to phenomics, including proteomics and metabolomics in the medical sciences. Mass spectrometry (MS) has been extensively used in phenomics studies of human PAs to clarify molecular mechanisms, and to discover biomarkers and therapeutic targets/drugs. MS-based

show abstract

Clinicopathologic Characteristics and Surgical Treatment of Plurihormonal Pituitary Adenomas

Cited by 11 publications

References 31 publications

Prolactinomas: Prognostic Factors of Early Remission After Transsphenoidal Surgery

Prolactinomas: Prognostic Factors of Early Remission After Transsphenoidal Surgery

Expression of additional transcription factors is of prognostic value for aggressive behavior of pituitary adenomas

The use of mass spectrometry in a proteome‐centered multiomics study of human pituitary adenomas

Contact Info

Product

Resources

About