Clinicopathologic and Immunologic Features Associated With Transformation of Mycosis Fungoides to Large-Cell Lymphoma

Cerroni, Lorenzo; Rieger, E.; Hödl, S; Kerl, Helmut

doi:10.1097/00000478-199206000-00002

Cited by 171 publications

(106 citation statements)

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“…The proliferation rate, as measured by staining with the monoclonal antibody Ki-67, is usually below 10% in patch and plaque lesions of MF (35). In contrast, several studies, including ours (see Table 3), demonstrated in excess of 30% Ki-67-positive cells in PR (6,8,9,36,37). Similarly, MF only rarely contains CD30 (Ki-1)-positive cells (38,39), whereas CD30 reactivity is variable in PR.…”

Section: Cd2mentioning

confidence: 52%

Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study

et al. 2000

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Pagetoid reticulosis (PR), also known as WoringerKolopp disease, is a form of cutaneous T-cell lymphoma that demonstrates striking epidermotropism on histologic examination. We present the histologic, immunologic, and molecular findings for seven patients who had PR. The patients ranged in age from 33 to 67 years. All patients presented with one or several thick plaques involving the distal extremities except for one patient, who presented with a tongue lesion.

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Section: Cd2mentioning

confidence: 52%

Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study

et al. 2000

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“…First, consistent with previous studies we did not find a difference in survival between patients with stage IIB with or without LCT at first diagnosis. 11,13 There were no major differences in age, percentage of folliculotropic MF, and extent of skin lesions between both groups (Table 5). In fact, prognostic unfavorable factors (eg, folliculotropic MF, generalized skin lesions) were even slightly more frequent in the MF stage IIB group without LCT, strengthening our conclusions that MF stage IIB with LCT at presentation do not necessarily worse than MF stage IIB without LCT at presentation.…”

Section: Percentage Of Blast Cellsmentioning

confidence: 89%

Prognostic factors in transformed mycosis fungoides: a retrospective analysis of 100 cases

Benner¹,

Jansen

Vermeer³

et al. 2012

Blood

190

182

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Large cell transformation (LCT) in mycosis fungoides (MF) is generally associated with an aggressive clinical course and poor survival, requiring aggressive therapeutic approach. However, a proportion of cases may follow an indolent clinical course. To identify prognostic factors, we analyzed the prognostic relevance of clinical, histologic, and immunophenotypical features in a large cohort of transformed MF patients, including 75 patients with only skin lesions, 19 patients with LCT in skin and lymph nodes, and 6 patients with LCT in lymph nodes only. Multivariate analysis of the total group showed that CD30 negativity, folliculotropic MF, extent of skin lesions and extracutaneous transformation were associated with reduced disease-specific survival (DSS) and, except for CD30 negativity and folliculotropic MF, also overall survival. In a multivariate analysis of 75 patients with only skin lesions at the time of LCT, CD30 negativity, folliculotropic MF and extent of skin lesions were independent parameters for both DSS and overall survival. Using the most discriminating parameters as a prognostic index, in both study groups differences in DSS between patients with 0-1 unfavorable prognostic factor(s) and > 2 unfavorable prognostic factors were statistically significant (P < .001). This prognostic index may be helpful in predicting prognosis and selecting the most appropriate treatment in patients with transformed MF. (Blood. 2012; 119(7):1643-1649)

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“…Large cell transformation in MF is defined by the presence of more than 25% of large lymphoid cells in the dermal infiltrates (1). This phenomenon is detected in more than half of patients with tumor stage MF and is associated with a poor prognosis (8). CD30…”

Section: Discussionmentioning

confidence: 99%

CD8+ mycosis fungoides with esophageal involvement: A case report

et al. 2012

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Abstract. Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma and is characterized clinically by an indolent course with slow progression. MF is limited to the skin with widespread distribution, however, extracutaneous involvement of MF occurs during the advanced stages of the disease. Esophageal involvement of MF is a rare event.In the present study, we describe the first documented case of CD8 + MF with esophageal involvement that was endoscopically diagnosed antemortem. A 70-year-old male with a 15-year history of MF presented with difficulty in swallowing. Endoscopic examination revealed a tumorous lesion with ulceration in all regions of the esophagus. Esophagus biopsy demonstrated atypical lymphocytic infiltrates with ulceration. Immunohistochemically, these atypical lymphocytes were positive for CD3, CD8 and cytotoxic granules. Therefore, a diagnosis of CD8 + MF involving the esophagus was made. Extracutaneous involvement of the esophagus in MF is extremely rare and the majority of previously reported cases have been diagnosed postmortem. Only two cases of MF with esophageal involvement endoscopically diagnosed antemortem have been previously reported and this is the first documented case of CD8 + MF with esophageal involvement diagnosed by this method. Early detection of extracutaneous involvement of MF is important for accurate treatment and endoscopic examination is a useful tool for detection of this pathology. IntroductionMycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma accounting for approximately 50% of all primary cutaneous lymphoma (1). MF is characterized clinically by an indolent course with slow progression, over years or occasionally decades, from patches to more infiltrated plaque and eventually tumor stages (1). MF is primarily limited to, but widely distributed on, the skin. However, during the advanced stages of the disease, MF has been identified in various extracutaneous regions, most commonly the lymph node, spleen, liver and lung (2). Esophageal involvement of MF has been previously identified, however cases are extremely rare (2-5).MF is characterized histopathologically by infiltrates of small to medium-sized neoplastic T lymphocytes with cerebriform nuclei demonstrating epidermotropism. The typical phenotype of neoplastic lymphocytes is CD3 + , CD4+ and CD8-(6). CD8 + MF has been identified, however, it is rare (6,7). In the present study, we report the first documented case of CD8 + MF with esophageal involvement that was diagnosed endoscopically antemortem. Patient and methodsCase report. A 70-year-old Japanese male with a 15-year history of MF presented with difficulty in swallowing. From the age of 56 years old, the patient reported observation of a gradually enlarging erythema on his left elbow. Four years following this, the patient was referred to Shiga University of Medical Science Hospital due to enlargement of the erythema across his entire body, accompanied by erosion in specific regions. Biopsy of the erythema led to di...

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Clinicopathologic and Immunologic Features Associated With Transformation of Mycosis Fungoides to Large-Cell Lymphoma

Cited by 171 publications

References 0 publications

Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study

Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study

Prognostic factors in transformed mycosis fungoides: a retrospective analysis of 100 cases

CD8+ mycosis fungoides with esophageal involvement: A case report

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