Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study

Abstract

Pagetoid reticulosis (PR), also known as WoringerKolopp disease, is a form of cutaneous T-cell lymphoma that demonstrates striking epidermotropism on histologic examination. We present the histologic, immunologic, and molecular findings for seven patients who had PR. The patients ranged in age from 33 to 67 years. All patients presented with one or several thick plaques involving the distal extremities except for one patient, who presented with a tongue lesion.

WHO-EORTC classification for cutaneous lymphomas

“…CD30 is often expressed. 73,74 Treatment. The preferred mode of treatment is radiotherapy or surgical excision.…”

Mycosis-fungoides-Type Cutaneous T Cell Lymphoma of the Hands and Soles: A Variant Causing Delay in Diagnosis and Adequate Treatment of Patients with Palmoplantar Eczema

“…Whereas histologically those cases are very similar or indistinguishable from epidermotropic MF-type CTCL [13, 14], immunohistochemically localized variants may differ to some extent. While MF-type CTCL is typically comprised of CD4-positive T lymphocytes [15, 16, 17], tumor cells of localized pagetoid reticulosis display a more variable and heterogeneous phenotype characterized by increased CD4 and/or CD8 positivity [18, 19, 20, 21]or CD4/CD8 negativity [12, 22]. In an approach to reconcile the similarities to MF-type CTCL with the unilesional or paucilesional nature and the favorable clinical course of this disease variant, localized pagetoid reticulosis is increasingly considered part of the disease spectrum of MF, representing the early or benign end of the clinical spectrum [12, 13, 14, 23, 24].…”

Pagetoide Retikulose bei einem Patienten mit Mycosis fungoides

“…Die PR wird als besondere Prä-sentationsform der Mycosis fungoides dem Stadium IA nach der TNM-Klassifikation zugeordnet. Ursprünglich wurden 2 Unterformen der PR unterschieden: F der lokalisierte Typ (Woringer-Kolopp) und F der disseminierte Typ (Ketron-Goodman), dessen Entität von verschiedenen Autoren angefochten wird [4].…”