Clinicoepidemiological profile of peritonitis complicating acute peritoneal dialysis: A single-center experience

Abstract

A prospective observational study examining the incidence and microbiological aspects of peritonitis complicating acute intermittent peritoneal dialysis (IPD) was performed. A total of 145 acute IPD treatments were included involving 112 patients. The majority of patients suffered from acute kidney injury (72.3%) secondary to sepsis. Peritonitis occurred in 31 treatment sessions, giving a frequency of 21.4% of procedures performed. The mean interval between starting dialysis and the first sign of peritonitis was 2.9 days, with 58% of cases occurring in the Intensive Care Unit. Frequent catheter manipulation/repositioning and leakages were identified as significant predisposing factors for peritonitis, and the risk of peritonitis was increased with longer duration of IPD. Gram-negative infections were more common than Grampositive infections. The use of systemic antibiotics did not prevent the development of peritonitis.

Study of the role of erythrocyte and leukocyte intoxication indexes in the pathogenesis of experimental peritonitis

“…The progression of peritonitis is also accompanied by the increasing aggregation activity of platelets, increased permeability of the wall of microvessels, their vasodilatation, the development of hypoxia and dissemination vascular syndrome [12,16]. The noted violations lead to multiple organ failure, which is the main cause of death from peritonitis [8,9].…”