Background COVID-19 (Coronavirus Disease-2019) is a pandemic disease, infecting more than 26.5 million people. Since there is no specific and effective treatment; early diagnosis and optimal isolation of the patient are of vital importance. Real-time polymerase chain reaction-based (RT-PCR) analyses do not achieve sufficient sensitivity in the diagnosis of the disease. Methods The data from 2217 patients diagnosed as COVID-19 between March 2020 and June 2020 and hospitalized or discharged with home isolation were retrospectively analyzed. Demographic data, comorbidities, PCR results, initial computed tomography (CT), laboratory values, Lactate Dehydrogenase (LDH) / Lymphocyte ratio, initial treatments and last status were recorded. The diagnostic sensitivity of LDH / Lymphocyte ratio, which is the main purpose of the study, was analyzed statistically. Results In order to test the effectiveness of LDH / Lymphocyte ratio for COVID-19 for diagnostic purposes, CT results were considered as gold standard. The area under the curve (AUC) was found to be 0.706 (p < 0.001; cut-off> 0.06) (Sensitivity: 76.4, specificity: 59.60). For the evaluation of LDH / Lymphocyte ratio in terms of survival, AUC was found to be 0.749 (p < 0.001; cut-off> 0.21) (Sensitivity: 70.59, specificity: 73.88). Conclusion Studies based on radiological findings have demonstrated that CT involvement has higher sensitivity. LDH / Lymphocyte ratio was analyzed in terms of diagnosis and mortality with using specific CT involvement as gold standard method which was found to be a more sensitive due to PCR false negativity; 0.06 and 0.21 were obtained as cut off values for diagnosis and mortality.
Background Severe inflammation and one or more extrapulmonary organ dysfunctions have been reported and this clinical picture is defined as "multisystem inflammatory syndrome in adults" (MIS-A) in severe coronavirus disease-2019 (COVID-19). We aimed to determine the effect of LDH/lymphocyte ratio (LLR) on the development of MIS-A. Methods The data of 2333 patients were retrospectively analyzed. Results MIS-A rate was found to be 9.9% and MIS-A related mortality was 35.3%. LRR level above 0.24 was found to predict MIS-A development with 70% sensitivity and 65.2% specificity. The risk of MIS-A development was found to be 3.64 times higher in those with LRR levels above 0.24 compared to those with 0.24 and below. In patients with MIS-A, LRR level above 0.32 predicts mortality with 78% sensitivity and 70% specificity. Conclusions Early detection of MIS-A with high sensitivity and specificity in a practical ratio is very important in terms new studies.
Benign tekrarlayan intrahepatik kolestaz, anatomik bir t›kanma olmaks›z›n gerçekleflen tekrarlay›c› kolestaz ve kafl›nt› ataklar› ile karakterize, nadir bir kal›tsal bozukluktur. Benign tekrarlayan intrahepatik kolestazda t›bbi tedavi
ÖzetAmaç: Bu çalışmada hastanemizde son altı yılda sağlık çalışanlarında meydana gelen delici kesici alet yaralanmalarının değerlendirilmesi, personele verilen eğitim uygulamalarının bildirim üzerine olan etkisinin incelenmesi amaçlanmıştır. Abs tractAim: The aim of this study was to evaluate needlestick and sharps injuries in our hospital for the last six years and the effects of education on the prevention of exposure to sharp instruments. Methods:We retrospectively evaluated sharp injuries occurred in our hospital between January 2007 and January 2013.Results: It was found that 229 sharp injuries were sustained within six years. During this period, 1.386 health-care workers received education and training on sharps injury prevention. Conclusion:We concluded that education and training of healthcare workers will increase sharps injury reporting rates and raise awareness and reduce the risk of sharps injuries. (The Me di cal Bul le tin of Ha se ki 2014; 52: 98-102)
Araştırma ÖZET Amaç: Güvenli kanın temini yaşamsal önem taşımaktadır. Bu nedenle donör kanlarında transfüzyonla bulaşan Hepatit B virüsü (HBV), Hepatit C Virüsü (HCV), İnsan İmmun Yetmezlik Virüsü (HIV) ve sifiliz etkeni taramaları yapılmaktadır. Bu çalışmada 2003-2012 yılları arasında kan merkezimize başvuran donörlerin tarama test sonuçları retrospektif olarak değerlendirilmesi ve seropozitiflik oranlarının yıllar içindeki değişiminin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Belirtilen dönemde yaşları 18-60 arasında değişen donörlerin kanlarında HBV, HCV, HIV ve RPR serolojileri değerlendirilmiş, seropozitifliklerin yıllara göre dağılımı yapılmıştır. Bulgular: Tarama testi yapılan 51.120 donörün 1.038'inde (% 2.03) HBsAg pozitifliği, 225 (% 0.44) donörde Anti HCV pozitifliği, VDRL/TPHA 154 (% 0.33) ve anti HIV pozitifliği 33 (% 0.06) tespit edilmiş, Anti HIV pozitif bulunan hastanın hiç birinde Western Blotla (WB) pozitif sonuçlanan olmamıştır. 2003'ten günümüze gelinliğinde HBsAg pozitiflik oranları belirgin olarak azalırken, bu düşüş diğer tarama testlerinde bu kadar belirgin gözlenememiştir. Sonuç: Donörler arasında HBsAg ve anti HCV pozitiflikleri günümüze gelindikçe azaldığı ve azalmanın istatistiksel olarak anlamlı olduğu gözlenmiştir. Tarama testlerinin seropozitiflik değerlerinin düşük tespit edilmesine rağmen, enfeksiyon riski halen devam etmektedir. Anahtar kelimeler: kan donorü, donör tarama testleri, HBs Ag, AntiHIV1, 2 Anti HCV, RPR SUMMARY Objective: The safety of blood has a vital importance.For this reason, donor bloods are screened for the presence of hepatitis B virus (HBV), hepatitis C virus (HCV),human immunodeficiency virus (HIV), and syphilis. In this study, results of the donor screening tests between the years 2003 and 2012 were evaluated retrospectively to assess the varations in seropositivity rates over years. Material and Methods: During the indicated period of time, test results for HBsAg, AntiHCV antibody, Anti HIV 1-2 antibody and RPR were evaluated for donors aged between 18-60 years, and their annual seropositivity rates were determined. Results: Evaluation of the test results of 51 120 donors revealed that 1038 (2.08 %) donors were HBsAg positive, 225 (0.44 %) anti HCV positive, 154 (0.33 %) RPR positive, 33 (0.06 %) anti HIV positive but none of them comfirmed by Western Blot (WB) tests. Seropositivity rates of HBs Ag decreased significantly from 2003 up to now, but this decreased rate was not observed in other screening tests. Conclusion: Seropositivity rates of HBsAg and anti HCV in blood donors decreased statistically significantly through years.Although these results indicated low seropositivity of infectious disease, risk of infection still persists.
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