Clinico-radiological findings of neuroendocrine tumour metastases to the orbit

Ryan, Tess G.; Juniat, Valerie; Stewart, Christopher M.; Malhotra, Raman; Hardy, Thomas G.; McNab, Alan A.; Davis, Garry; Selva, Dinesh

doi:10.1080/01676830.2021.1895845

Cited by 4 publications

(7 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neuroendocrine tumour deposits are radiologically well-de ned, with round or fusiform masses and contrast-enhancing lesions (11). In most patients, the mass was limited to the extraocular muscle or extended to the adjacent orbital or lacrimal gland tissue.…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine tumours of the orbit: report of three cases and a literature review

Qiao

Wang

2023

Preprint

View full text Add to dashboard Cite

Background Neuroendocrine tumours (NETs) are malignancies originating from neuroendocrine cells. NETs mainly occur in the gastrointestinal tract and lungs and can metastasise to the eye orbit in rare cases. We analysed three orbital NET cases in the present study and described their clinicopathologic factors, treatments and prognosis. Case presentation Three orbital NET cases were described in the present study. The average age of the patients was 59 years old. One patient was male, and two were female. Two of them showed ocular symptoms, including unilateral proptosis and eyelid mass; the other showed systemic symptoms as Cushing syndrome. The three patients underwent surgical resection of the tumour. Tumours were analysed using immunohistochemistry assays and were positive for PCK and EMA. Besides, two patients were positive for CD56 and Syn. Cases 1 and 2 were pathologically diagnosed with "neuroendocrine carcinoma", refused treatment, and died three months later. Case 3 was diagnosed with a "neuroendocrine tumour", and after the operation, the Cushing syndrome symptoms gradually disappeared. Finally, no recurrence was found after four years of follow-up. Conclusion Neuroendocrine tumours can originate from orbit and show different clinical manifestations due to the different types of orbital NETs. Pathology can clarify the diagnosis, classification and grading, provide a reference value for treatment strategy and prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Neuroendocrine tumours of the orbit: report of three cases and a literature review

Qiao

Wang

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Typical radiographic findings play a crucial role in diagnosing NENs. Orbital NENs often present as heterogeneous, well-circumscribed, and contrast-enhancing lesions on CT. 3 The masses are mostly confined to the extraocular muscles, with some cases extending into the adjacent orbital or lacrimal gland tissues. On MRIs, these lesions typically appear moderately hypointense or isointense on T1-weighted imaging, and isointense or mildly hyperintense on T2-weighted imaging.…”

Section: Discussionmentioning

confidence: 99%

“…In May 2021, a CT scan showed a well-defined peribulbar nodule measuring 2.2 Â 1.9 Â 2.1 cm in the area of the orbital muscle cone and nasolacrimal duct (Figure 2b and 2c). One month later, a magnetic resonance imaging (MRI) scan revealed a maximum cross-section of the lesion measuring 4.0 Â 3.2 cm (Figure 2e [1][2][3][4]). The mass was surgically resected through a transcutaneous orbitotomy approach, revealing a large grey-white neoplasm with hard and brittle characteristics in the left orbit (Figure 2f).…”

Section: Department Of Ophthalmology Westmentioning

confidence: 99%

“…Despite negative findings in the pituitary enhanced MRI, an enhancement was incidentally discovered in the lateral rectus muscle of the patient's left orbit. Subsequently, an orbital enhanced MRI was performed, and an enhanced orbital mass was found encompassing the left orbital lateral rectus muscle (Figure 3b [1][2][3][4]). Surgery was then performed through a lateral orbitotomy approach.…”

Section: Casementioning

confidence: 99%

“…1 NENs may occur in various organs and tissues, including the gastrointestinal tract, lungs, pancreas and bronchus. 2 Orbital NENs are rare and exhibit atypical clinical and imaging manifestations, 3 which pose challenges in their diagnosis. Therefore, it is crucial for ophthalmologists and pathologists to be well-versed in the clinicopathological features of orbital NENs to facilitate early and accurate treatment interventions.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neuroendocrine neoplasms of the orbit: report of three cases and a literature review

Qiao,

Wang,

2023

J Int Med Res

View full text Add to dashboard Cite

Neuroendocrine neoplasms (NENs) originate from neuroendocrine cells, and mainly occur in the gastrointestinal tract and lungs, rarely occurring in the orbit. Here, the clinicopathologic factors, treatments and prognosis of three cases of orbital NENs are described. The mean age of the three patients (two females and one male) was 59 years. Two cases exhibited ocular symptoms, including unilateral proptosis and eyelid mass, while the third case presented systemic symptoms exhibited as Cushing’s syndrome. The tumours were surgically resected in all three patients. Immunohistochemistry assays revealed positive expression for pan cytokeratin and epithelial membrane antigen in all cases. Additionally, neural cell adhesion molecule 1 (also known as CD56) and synaptophysin were positive in two cases. The pathological diagnosis for case 1 and 2 was ‘neuroendocrine carcinoma’ and both patients died three months after diagnosis. Case 3 was diagnosed with a neuroendocrine tumour and the symptoms of Cushing’s syndrome gradually improved following surgery. In addition, no recurrence was observed during the four-year follow-up period. These cases demonstrate that orbital neuroendocrine tumours show different clinical manifestations due to the different types. Pathology may clarify the diagnosis, classification and grading, and provide a reference value for treatment and prognosis.

show abstract

Extraocular muscle enlargement

Rana

Juniat

Patel

et al. 2022

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Extraocular muscle enlargement can occur secondary to a range of orbital and systemic diseases. Although the most common cause of extraocular muscle enlargement is thyroid eye disease, a range of other inflammatory, infective, neoplastic, and vascular conditions can alter the size and shape of the extraocular muscles. Imaging with computed tomography and magnetic resonance imaging plays an essential role in the workup of these conditions. This article provides an image-rich review of the wide range of pathology that can cause enlargement of the extraocular muscles.

show abstract

Clinico-radiological findings of neuroendocrine tumour metastases to the orbit

Cited by 4 publications

References 58 publications

Neuroendocrine tumours of the orbit: report of three cases and a literature review

Neuroendocrine tumours of the orbit: report of three cases and a literature review

Neuroendocrine neoplasms of the orbit: report of three cases and a literature review

Extraocular muscle enlargement

Contact Info

Product

Resources

About