Clinico-pathological study to evaluate oral lichen planus for the establishment of clinical and histopathological diagnostic criteria

Hiremath, Santhosh Kumar S; Kale, Alka D; Hallikerimath, Seema

doi:10.5146/tjpath.2014.01285

Cited by 12 publications

(15 citation statements)

References 14 publications

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“…Our results confirm that there is no relation between the different clinical and histopathological subtypes of this disease, as has been presented in other studies (2,7,10,11). Therefore, we consider that the histopathological characteristics observed in the biopsies of this disorder should not be used as infallible and specific diagnostic criteria.…”

Section: Discussionsupporting

confidence: 92%

“…Most studies (2,7,10,11) agree, that the application of the WHO diagnostic criteria, modified by van der Meij and van der Waal in 2003 (8) for lichenoid processes, has proven to be inefficient in establishing a good correlation between the clinical and histopathological diagnosis, and to differentiate between oral lichen planus (OLP) and oral lichenoid lesions (OLL). Nonetheless, the study by Rad et al in 2009 (12), showed a good correlation between the clinical and the histopathological aspects.…”

Section: Introductionmentioning

confidence: 99%

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Histopathological characterization of the oral lichenoid disease subtypes and the relation with the clinical data

Alberdi-Navarro¹,

Marichalar-Mendía²,

Mj³

et al. 2017

Med Oral

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BackgroundThe aim of the study was to analyze the histopathological characteristics of samples with a diagnosis of oral lichenoid disease (OLD) and their link with the location and the type of clinical lesion, and the clinicopathological subtypes.Material and MethodsRetrospective study on 85 consecutive patients diagnosed with OLD (58 women and 27 men, mean age of 57.7 years). Clinical and histopathological characterization of each case (modified WHO criteria). Collection of the clinical and histopathological data of the lesions. Descriptive and comparative statistical analysis of the results.ResultsThe 78.8% of the cases were considered clinically typical while the 21.2% were considered compatible. Histologically, 52.9% were classified as typical and 47.1% as compatible. Biopsies from “plaque-like” lesions presented hyperkeratosis (p<0.001) and epithelial dysplasia (p=0.06) more frequently. Furthermore, acute inflammation was more evident in erosive-ulcerative lesions (p=0.001). Differences regarding the location of the biopsy were statistically non-significant. However, 42.9% of the tongue biopsies showed epithelial dysplasia.ConclusionsThe histopathological aspect of this disorder is not specific and does not allow us to differentiate between the main subtypes. Therefore, the main reasons to perform a biopsy in this disorder are to define the differential diagnosis and to rule out epithelial dysplasia or a carcinoma. The final histopathological result may be subject to the type of lesion that is biopsied. Key words:Oral lichenoid disease, histopathology, subtypes, characterization, oral lichen planus, oral lichenoid lesion, epithelial dysplasia.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Histopathological characterization of the oral lichenoid disease subtypes and the relation with the clinical data

Alberdi-Navarro¹,

Marichalar-Mendía²,

Mj³

et al. 2017

Med Oral

View full text Add to dashboard Cite

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“…According to the World Health Organization, OLP is a highly prevalent disease that can progress to oral cancer. It is also considered a potentially malignant disorder that should be closely supervised …”

Section: Introductionmentioning

confidence: 99%

Psychological disorders and oral lichen planus: A systematic review

Cerqueira

Moura

Arsati

et al. 2018

J of Invest & Clin Dent

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The aim of the present study was to identify and analyze scientific evidence available in the literature to answer the following question: Are psychological disorders associated with the development of oral lichen planus (OLP)? Using scientific databases (PubMed, LILACS, and Science Direct), a literature search was conducted between December 2016 and January 2017, using previously selected keywords. Two independent reviewers critically assessed the results in three stages, strictly obeying the inclusion and exclusion criteria defined in the study protocol. We assessed paper quality based on STROBE (Strengthening The Reporting of Observational studies in Epidemiology). After analysis, we selected 14 papers, of which 10 showed evidence of association between psychological disorders (in particular, stress, anxiety, and depression) and the development of OLP. The paper-quality assessment by means of STROBE showed that 13 papers presented intermediate quality and one paper presented high quality. In the present systematic review, we found an association between psychological disorders and the development of OLP. K E Y W O R D Sanxiety, depression, oral lichen planus, stress, systematic review

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“…However, a lack of validated clinical or histological criteria and substantial interobserver variability has been documented for both clinical and histological assessment . A recent study showed only mild to moderate clinicopathological correlation in the diagnosis of OLP . The absence of histopathological correlation may reflect variation in the nature (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8] A recent study showed only mild to moderate clinicopathological correlation in the diagnosis of OLP. 9 The absence of histopathological correlation may reflect variation in the nature (i.e. erosive vs. hyperkeratotic), chronicity and location of OLP lesions.…”

Section: Introductionmentioning

confidence: 99%