Clinico-pathological features of tuberculosis due to Mycobacterium tuberculosis Uganda genotype in patients with tuberculous lymphadenitis: a cross sectional study

Abstract

BackgroundTuberculous lymphadenitis is next to pulmonary tuberculosis as the most common cause of tuberculosis. Uganda genotype, one of the sub-lineages of Mycobacterium tuberculosis, is the most prevalent cause of pulmonary tuberculosis in Uganda. We here investigate the clinicopathological characteristics of patients with tuberculous lymphadenitis infected with M. tuberculosis Uganda genotype compared with those infected with M. tuberculosis non-Uganda genotype strains.MethodsBetween 2010 and 2012, we enrolled 121 patients (mean age 28.5 yrs, male 48%; female 52%) with tuberculous lymphadenitis, and categorized them by their M. tuberculosis genotypes. The clinical features and lymph node cytopathological parameters were compared between patients in the Uganda and non-Uganda categories using a crude and multivariable logistic regression model with adjustment for confounding factors.ResultsOf the 121participants, 56 (46%) were infected with strains of Uganda genotype. Patients infected with this genotype had significantly lower frequency of abdominal lymphadenopathy (odds ratio 0.4, p = 0.046) after adjusting for sex, age and HIV. Abdominal lymphadenopathy was also significantly associated with abnormal chest X-ray (p = 0.027).ConclusionTuberculous lymphadenitis patients infected with M. tuberculosis Uganda genotype were significantly less prone to have abdominal lymphadenopathy indicating potential reduced ability to disseminate and supporting the concept that differences in M. tuberculosis genotype may have clinical implications.

Epidemiology of tuberculous lymphadenitis in Africa: A systematic review and meta-analysis

“…Of the total of 28 articles reviewed, 14 articles were from Ethiopia [16, 26, 37–48] two articles each from Zambia [49, 50], South Africa [51, 52] and Nigeria [53, 54]. One article each were identified from Burkina Faso [55], Uganda [56], Djibouti [57], Mozambique [58], Sudan [59], Tunisia [60], Tanzania [61], and Malawi [62]. Data collection period of articles was between 1970 and 2015 (46 years) while the publication years range was between 1975 and 2018 (44 years) (Table 1).…”

Impact of Mycobacterium tuberculosis complex lineages as a determinant of disease phenotypes from an immigrant rich moderate tuberculosis burden country

“…Association of Uganda-I lineage to gastro intestinal sites of infection was another significant finding. The Uganda-I lineage has not been studied in detail as a cause of EPTB and therefore very much limited information is only available in literature on its association with any clinical manifestation [30].…”

Uncommon features in conventional oral squamous cell carcinoma

“…The tertiary lymphoid strucutres (TLSs) are chiefly found in the peri-tumoural stroma within 0.5 mm distance from the tumour front, in lymphocyte rich areas. [ 18 ]…”