Uncommon features in conventional oral squamous cell carcinoma

Sudhakara, M; Venugopal, R.; Khan, Nawal; Amulya, S R

doi:10.4103/0973-029x.185905

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…As a result, surgical management as a single‐modality therapy is the typical approach for those who develop OSCC and is often satisfactory for localized tumors. The first lesion described in the present case was diagnosed as a well‐differentiated OSCC presenting stromal desmoplasia, a feature already described in all types of OSCC and related to poor outcome 12–15 . Some authors also suggest that it can predict occult neck metastasis in patients with OSCC 13 .…”

Section: Discussionsupporting

confidence: 67%

“…The first lesion described in the present case was diagnosed as a well-differentiated OSCC presenting stromal desmoplasia, a feature already described in all types of OSCC and related to poor outcome. [12][13][14][15] Some authors also suggest that it can predict occult neck metastasis in patients with OSCC. 13 Diagnosis of locally advanced disease discloses low success rates for curative attempts.…”

Section: Discussionmentioning

confidence: 99%

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Fanconi anemia and hematopoietic stem cell transplant as risk factors for oral squamous cell carcinoma: A case report with a 12‐year follow‐up

Macedo

Domaneschi

Luiz

et al. 2021

Special Care in Dentistry

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Fanconi anemia is a rare disorder resulting from defects in genes responsible for DNA damage responses. It is characterized by congenital anomalies, aplastic anemia, and a predisposition to cancer. Currently, hematopoietic stem cell transplant (HSCT) is the only curative treatment available for bone marrow failure; however, HSCT increases oral squamous cell carcinoma (OSCC) risk. Here we report the case of a patient diagnosed with Fanconi anemia in childhood who was treated with HSCT and later diagnosed with multiple OSCCs during a 12‐year follow‐up. Despite multiple surgical interventions and radiotherapy regimens, the patient`s health deteriorated. Management of individuals with Fanconi anemia is challenging and must be provided by a multidisciplinary healthcare team to ensure better staging, treatment planning, and coordination.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Fanconi anemia and hematopoietic stem cell transplant as risk factors for oral squamous cell carcinoma: A case report with a 12‐year follow‐up

Macedo

Domaneschi

Luiz

et al. 2021

Special Care in Dentistry

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“…Well-differentiated SCCs almost resemble Malpighian cells of the normal epithelium. However, they disrupt the basal membrane and invade the underlying corium under various patterns of uncontrolled growth, with loss of polarity, development of dyskeratosis and the formation of ‘keratin pearls’ ( 82 ).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics predicting advanced stage and surgical margin invasion of oral squamous cell carcinoma: A single‑center study on 10 years of cancer registry data

et al. 2022

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The incidence profile of oral squamous cell carcinoma (OSCC) has not previously been comprehensively reported in Indonesia. The present study aimed to identify clinicopathological characteristics of patients with OSCC according to sex and age, to analyze histological differentiation patterns specific to tumor subsites, to highlight the role of lymphovascular invasion (LVI) in metastasis, and to develop a model to predict advanced stage and margin invasion. A retrospective cross-sectional study was performed using 581 medical records and pathological specimens from cancer registry data in the Dr Cipto Mangunkusumo Hospital (Jakarta, Indonesia), between January 2011 and December 2020. Clinicopathological characteristics were analyzed using parametric and non-parametric tests. Multivariate logistic regression analyses were performed for eligible parameters, identified using bivariate analysis, to predict advanced stage and margin invasion. Calibration of the prediction model was evaluated using the Hosmer-Lemeshow test, its discrimination value assessed using the receiver operating characteristic and area under the receiver operating characteristic curve (AUC). Sex-specific patterns in tumor subsites and differences in clinical staging according to age were demonstrated in the patients with OSCC. The proportion of well-differentiated cases was significantly higher in most tumor subsites, except in the buccal mucosa (more moderately differentiated cases) and floor of the mouth (well and moderately differentiated cases being equal). LVI was significantly associated with nodal metastasis but not distant metastasis. Multivariate analysis demonstrated that age ≤45 years [odds ratio (OR), 2.26] and LVI (OR, 8.42) predicted patients having advanced-stage OSCC among general populations (AUC, 0.773); however, LVI (OR, 8.28) was the sole predictor of advanced stage amongst young patients (AUC, 0.737). Margin invasion was predicted solely by tumor subsite, including mouth not otherwise specified (OR, 3.04) and palate (OR, 6.13), in the general population (AUC, 0.711). Furthermore, margin invasion was predicted by the palate subsite (OR, 38.77) and LVI (OR, 11.61) in young patients (AUC, 0.762). Investigating young patients thoroughly when finding SCC in the mouth and palate, and assessing LVI, especially among young patients, is critical to prevent advanced staging and margin invasion.

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“…I.A.R.C. "(International Agency for Research on Cancer)" has predicted that, by the year 2035, the incidence of oral cancer in India will be around 1.7 billion [1]. Many authors have described different grading systems to identify and classify OSCC histologically.…”

Section: Introductionmentioning

confidence: 99%

“…can show the presence of giant cells due to a foreign body reaction to keratin. They can also be detected as a result of the formation of "malignant tumor giant cells" in "poorly differentiated carcinomas" [1]. The appearance of malignant tumor giant cells is explained with the help of various mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Significance Of Tumor Giant Cells In Oral Squamous Cell Carcinoma: A Case Report

KHAN

2022

JODRDMIMS

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Background : Oral squamous cell carcinoma (OSCC) is the most common cancer of the oral cavity. OSCC presents with some typical histopathological characteristics like dysplastic epithelial cells with variable degrees of squamous differentiation. These histopathological features make it relatively easy to diagnose conventional squamous cell carcinoma. However, some cases show certain unique features that help in determining the prognosis of the disease. These features include epithelial-mesenchymal interaction, stromal hyalinization, clear cell change, stromal desmoplasia, perineural invasion, vascular invasion, tissue eosinophilia, giant cells and tertiary lymphoid follicle formation. The presence of giant cells in OSCC can be the result of foreign body reaction to keratin or due to formation of malignant tumor giant cells in poorly differentiated carcinomas. The giant cells showing pleomorphic features can be helpful in predicting the prognosis of the disease.

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Uncommon features in conventional oral squamous cell carcinoma

Cited by 7 publications

References 16 publications

Fanconi anemia and hematopoietic stem cell transplant as risk factors for oral squamous cell carcinoma: A case report with a 12‐year follow‐up

Fanconi anemia and hematopoietic stem cell transplant as risk factors for oral squamous cell carcinoma: A case report with a 12‐year follow‐up

Clinicopathological characteristics predicting advanced stage and surgical margin invasion of oral squamous cell carcinoma: A single‑center study on 10 years of cancer registry data

Significance Of Tumor Giant Cells In Oral Squamous Cell Carcinoma: A Case Report

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