Clinico-pathological features of a series of 11 oncocytic endocrine tumours of the pancreas

Volante, Marco; Rosa, Stefano La; Castellano, Isabella; Finzi, Giovanna; Capella, Carlo; Bussolati, Gianni

doi:10.1007/s00428-006-0154-0

Cited by 40 publications

(36 citation statements)

References 34 publications

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“…There are also some medullary carcinomas composed of Hürthle cells that are morphologically indistinguishable from those derived from the follicular cells [72]. The occurrence of Hürthle cell transformation in medullary thyroid carcinoma fits with its occurrence in other neuroendocrine tumours throughout the body [73][74][75].…”

Section: Mitochondrion-rich and Oncocytic (Hürthle Cell) Tumoursmentioning

confidence: 97%

Mitochondria and cancer

et al. 2009

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Section: Mitochondrion-rich and Oncocytic (Hürthle Cell) Tumoursmentioning

confidence: 97%

Mitochondria and cancer

et al. 2009

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“…These rare variants should be taken into account because can give diagnostic difficulties, especially when looking at small bioptic specimens. They enter in the differential diagnosis with the more common oncocytic PanNETs (17) and undifferentiated carcinomas (18). Moreover, clear cell ACCs have been described anecdotally and recently observed by us in a liver metastasis and by Dr. Mounajjed (Mayo Clinic, Rochester, MN, USA) in a primary pancreatic ACC.…”

Section: Acinar Cell Carcinoma In Adultsmentioning

confidence: 99%

Acinar Cell Carcinoma of the Pancreas: Overview of Clinicopathologic Features and Insights into the Molecular Pathology

Rosa¹,

2015

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Acinar cell carcinomas (ACCs) of the pancreas are rare pancreatic neoplasms accounting for about 1–2% of pancreatic tumors in adults and about 15% in pediatric subjects. They show different clinical symptoms at presentation, different morphological features, different outcomes, and different molecular alterations. This heterogeneous clinicopathological spectrum may give rise to difficulties in the clinical and pathological diagnosis with consequential therapeutic and prognostic implications. The molecular mechanisms involved in the onset and progression of ACCs are still not completely understood, although in recent years, several attempts have been made to clarify the molecular mechanisms involved in ACC biology. In this paper, we will review the main clinicopathological and molecular features of pancreatic ACCs of both adult and pediatric subjects to give the reader a comprehensive overview of this rare tumor type.

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“…22 However, some pancreatic neuroendocrine neoplasms (PanNETs) can show oncocytic features; the majority of which are malignant or of uncertain malignant potential. 23 Cytomorphologic features of oncocytic variants of PanNETs consist of cohesive clusters of large cells with abundant eosinophilic, granular cytoplasm, anisonucleosis, prominent nucleoli, and relatively smooth nuclear membranes. Nuclei are round to oval with finely granular chromatin.…”

Section: Discussionmentioning

confidence: 99%

Fine-Needle Aspiration Biopsy Diagnosis of Oncocytic Carcinoma of the Pancreas

Zhao¹,

Allam-Nandyala²,

Centeno³

2015

Pathology Case Reviews

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Oncocytic carcinoma of the pancreas is a very rare variant of pancreatic ductal adenocarcinoma. Fine-needle aspiration biopsy reports of this tumor are exceptionally rare. We report the case of a 65-year-old female patient who presented with a mass in the head of the pancreas. The mass was sampled by fine-needle aspiration biopsy on 2 separate occasions, and both samples were diagnosed as oncocytic carcinoma of the pancreas. The patient underwent a Whipple resection, and histopathologic examination of the resection specimen showed an invasive oncocytic carcinoma arising from intraductal oncocytic papillary neoplasm with highgrade dysplasia. Here we discuss the cytologic and histological features, differential diagnoses, utility of ancillary studies, and the recently updated knowledge about this rare entity.A s a very rare variant of pancreatic ductal adenocarcinoma (PDAC), oncocytic carcinoma of the pancreas has distinctive histological and cytologic features. Arising from the oncocytic subtype of the intraductal papillary mucinous neoplasm (IPMN-O), 1 also known as intraductal oncocytic papillary neoplasm, it was first described by Adsay et al 2 in 1996. The oncocytic subtype of IPMN is a very rare form of IPMN (<5% of all IPMNs), 3 consisting of complex, arborizing papillary intraductal projections of cuboidal cells with finely granular oncocytic cytoplasm, and diffusely present goblet cells. Oncocytic carcinoma of the pancreas is thought to be a subtype of PDAC; however, several reports have indicated that patients with oncocytic carcinoma have significantly better outcomes than do those with classic PDAC (median survival of 132 months for oncocytic carcinoma vs 18 months for PDAC). 1,4-6 Moreover, KRAS mutations, which are seen in more than 90% of PDACs, were rare in oncocytic carcinomas (20%). 1 The different prognostic and molecular features may lead to different therapeutic interventions. Therefore, it is essential to accurately diagnose this entity, especially on preoperative sampling. However, because of its rarity, oncocytic carcinoma of pancreas has been reported only in single case reports and small series. Reports describing the cytologic features in 4 prior cases are summarized in Table 1. [7][8][9] Here we report the case of a patient presenting with oncocytic carcinoma of the pancreas, which was diagnosed preoperatively by fine-needle aspiration biopsy (FNAB). Its morphological features, ancillary study results and follow-up information are described to enrich our understanding of this neoplasm. CASE REPORTThis case report is conducted following the guidelines of the Scientific Review Board of Moffitt Cancer Center and the institutional review board of the University of South Florida.A 65-year-old woman presented to an outside institution with an unexplained 25-lb weight loss and acute cholecystitis. Magnetic resonance cholangiopancreatography was performed to assess her biliary system for possible common bile duct stones. At magnetic resonance cholangiopancreatography, dilation of the main pancre...

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Clinico-pathological features of a series of 11 oncocytic endocrine tumours of the pancreas

Cited by 40 publications

References 34 publications

Mitochondria and cancer

Mitochondria and cancer

Acinar Cell Carcinoma of the Pancreas: Overview of Clinicopathologic Features and Insights into the Molecular Pathology

Fine-Needle Aspiration Biopsy Diagnosis of Oncocytic Carcinoma of the Pancreas

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