Clinico-morphological patterns of breast cancer including family history in a New Delhi hospital, India-A cross-sectional study

Saxena, Sunita; Rekhi, Bharat; Bansal, Anju; Bagga, Ashok; Chintamani,; Murthy, N S

doi:10.1186/1477-7819-3-67

Cited by 94 publications

(56 citation statements)

References 19 publications

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“…[10] The average age of the patient at presentation is between 45 and 50 years[101112] and similarly observed in present study. The peak age of breast cancer is 60-70 years in western countries and 40-50 years in Asian countries.…”

Section: Discussionsupporting

confidence: 82%

A retrospective study of clinico-pathological spectrum of carcinoma breast in a West Delhi, India

Nigam

Yadav

Sood

2014

South Asian J Cancer

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Background:Data on the demographic profile of breast cancer patients from Delhi is scarce and whatever is available is from higher referral center. Our hospital caters to patients from an urban population of the lower socioeconomic strata and is a representation of cases at a tertiary care hospital in west Delhi. In Delhi, breast cancer (26.8%) is commonest cancer among the female followed by cervix (12.5%), gallbladder (7.2%), ovary (7.1%), and uterus (3.3%).Aims and Objectives:A retrospective audit of breast cancer patients presenting at a tertiary referral center from 2004 to 2011.Materials and Methods:A total of 328 cases diagnosed as carcinoma breast on histopathology from year 2004 to 2011 were retrieved and studied retrospectively with regards to demographic profile and their histological features with estrogen receptor (ER), progesterone receptor (PR), and Her2neu status.Results:The median age of presentation was 49 years of age. Infiltrating ductal carcinoma (IDC, not otherwise specified (NOS)) was the commonest histopathological variant (81.40%) followed by medullary carcinoma (10.36%) and mucinous carcinoma (2.74%). Triple negative were found to be the commonest group comprising 39.4% of all the cases followed by ER and PR both positive. Pathological tumor, node, and metastasis (TNM) staging showed most common group was T2N0M0 (19.5%) followed by T2N1M0 (17.1%) and T2N2M0 (14%).Conclusion:The incidence of breast cancer in the India and include a higher incidence of ER, PR, and Her2neu negative disease in west Delhi.

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Section: Discussionsupporting

confidence: 82%

A retrospective study of clinico-pathological spectrum of carcinoma breast in a West Delhi, India

Nigam

Yadav

Sood

2014

South Asian J Cancer

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“…With regard to the parity among the breast cancer patients, all the patients in our study were multiparous and married, although nulliparity is a risk factor for breast cancer. This was comparable to figures shown by Sexana et al (10) . The tumour location for most 35/50 (70%) of patients was on the left breast.…”

Section: Discussionsupporting

confidence: 81%

“…Most of them were middle aged at presentation. The age at presentation among the studied breast cancer patients was 47.3±5.8 years, this age of presentation was in accordance with the study of Sunita Sexana et al (10) , Raina V. et al (11) , Fakhro A.E. et al (12) , Priya Hazrah et al (13) .…”

Section: Discussionsupporting

confidence: 76%

Impact of Chemoradiation on Lung Function in Breast Cancer Survivours

Haq¹

2017

JMSCR

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“…Early-onset breast cancer may, in part, be biologically different from breast cancer patients in older patients [38]. Family history contributes to only 20% of the early onset cases whereas factors responsible for the rest of the breast cancer cases in young women are not known [39]. Difference in clinical behavior and molecular profile of early onset breast cancer suggest the need for understanding the risk factors and molecular mechanisms involved in development of breast cancer in young women.…”

Section: Discussionmentioning

confidence: 99%

Establishment and characterization of two primary breast cancer cell lines from young Indian breast cancer patients: mutation analysis

et al. 2014

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Two novel triple negative breast cancer cell lines, NIPBC-1 and NIPBC-2 were successfully established from primary tumors of two young breast cancer patients aged 39 and 38 years respectively, diagnosed as infiltrating duct carcinoma of breast. Characterization of these cell lines showed luminal origin with expression of epithelial specific antigen and cytokeratin 18 and presence of microfilaments and secretary vesicles, microvilli, tight junctions and desmosomes on ultra-structural analysis. Both the cell lines showed anchorage independent growth and invasion of matrigel coated membranes. Karyotype analysis showed aneuploidy, deletions and multiple rearrangements in chromosomes 7, 9, X and 11 and isochromosomes 17q in both the cell lines. P53 mutational analysis revealed no mutation in the coding region in both the cell lines; however NIPBC-2 cell line showed presence of heterozygous C/G polymorphism, g.417 C > G (NM_000546.5) resulting in Arg/Pro allele at codon 72 of exon 4. Screening for mutations in BRCA1&2 genes revealed presence of three heterozygous polymorphisms in exon 11 of BRCA1 and 2 polymorphisms in exons 11, and14 of BRCA2 gene in both the cell lines. Both the cell lines showed presence of CD 44+/24-breast cancer stem cells and capability of producing mammosphere on culture. The two triple negative breast cancer cell lines established from early onset breast tumors can serve as novel invitro models to study mechanisms underlying breast tumorigenesis in younger age group patients and also identification of new therapeutic modalities targeting cancer stem cells.

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Clinico-morphological patterns of breast cancer including family history in a New Delhi hospital, India-A cross-sectional study

Cited by 94 publications

References 19 publications

A retrospective study of clinico-pathological spectrum of carcinoma breast in a West Delhi, India

A retrospective study of clinico-pathological spectrum of carcinoma breast in a West Delhi, India

Impact of Chemoradiation on Lung Function in Breast Cancer Survivours

Establishment and characterization of two primary breast cancer cell lines from young Indian breast cancer patients: mutation analysis

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