Clinico-epidemiological study of childhood psoriasis

Abstract

<p>The clinico-epidemiological data of 276 childhood psoriasis were studied. The mean age was 7.64 years (range 1 day to 15 years). There was no complain of any discomfort in 198 cases. Itching was present in 67 cases and burning in 11 cases. Plaque psoriasis was the most common type (68.8%) followed by guttate (18.8%). Erythrodermic and pustular psoriasis were found in 2.2% and 1.5% cases. Scalp was the most frequently affected site (75.36%) followed by extensors of extremities (41.3%), trunk (37.7%), palm and/or sole (13.0%) and diaper area (11.6%). Nail involvement was found only in 8%, joint was affected in 3.6% and only 2.2% children with psoriasis were erythrodermic. In Bangladeshi children with psoriasis, plaque is the most common type and scalp is the mostly affect site. Nail and joint involvement is less common. Pustular and erythrodermic psoriasis is rare.</p>

Prevalence, Clinical Pattern and Presentations of Psoriasis in A Tertiary Care Hospital of Bangladesh

“…The frequency of psoriasis was lower in the older age group in this study, similar to documentation from the UK. 14 In this study 6.45% patient have family history of psoriasis among first degree relatives which is consistent with a previous study of childhood psoriasis in Bangladesh by Bhuyan et al 15 . More than one-fifth of psoriasis patients seen in this study (21.8%) presented in the first two decades of.…”

Response to Letter to the editor: ‘Psoriasis dermatitis: an overlap condition of psoriasis and atopic dermatitis in children’

“…Moreover, in the absence of defined diagnostic criteria, researchers' classification of PD could be variable, explaining the heterogeneity of prevalence estimates in the literature. 4,5,7,9 These differences could also be explained by the different geographical scope of the studies.…”

Plasma alpha-2-macroglobulin level in moderate to severe psoriasis

“…Psoriasis is a T cell mediated disease, associated with aberrant inflammation and the production of pro-inflammatory mediators including TNF-, IL-17, IL-23, and other cytokines (IL-1 , IL-1 , IL-6, IL-15, IL-18 and IL-20). [4][5][6][7] Psoriasis is associated with a range of co-morbidities that include some chronic inflammatory conditions with overlapping pathology including rheumatoid arthritis, inflammatory bowel disease and other metabolic diseases. 8 The 2 macroglobulin ( -2M) serving as a unique panproteinase inhibitor also involved in binding and the removal of cytokines support a balanced and properly functioning immune system in mammalian body.…”