Clinically relevant thyroid disorders and inflammatory bowel disease are inversely related: a retrospective case-control study

Dore, Maria Pina; Fanciulli, Giuseppe; Manca, Alessandra; Cocco, V. Lo; Nieddu, Alessandra; Murgia, Michele

doi:10.1080/00365521.2020.1861323

Cited by 4 publications

(1 citation statement)

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“…A retrospective cross-sectional study, limited to individuals with CD, demonstrated only a statistically marginal reduction in the prevalence of hypothyroidism, whereas no significant change was observed in hyperthyroidism ( 35 ). A retrospective, single-center, case-control study indicated that patients with IBD have a reduced likelihood of developing thyroid disorders ( 36 ). Routine hormonal assessments and thyroid gland imaging may not be necessary in the absence of clinical signs or symptoms.…”

Section: Discussionmentioning

confidence: 99%

Casual associations of thyroid function with inflammatory bowel disease and the mediating role of cytokines

Wu,

Yi,

2024

Front. Endocrinol.

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BackgroundPrevious observational epidemiological studies have suggested a potential association between thyroid function and inflammatory bowel disease (IBD). However, the findings remain inconclusive, and whether this association is causal remains uncertain. The objective of this study is to investigate the causal association between thyroid function and IBD.MethodsGenome-wide association studies (GWAS) involving seven indicators of thyroid function, IBD, and 41 cytokines were analyzed. Bidirectional two-sample Mendelian randomization (MR) and multivariable MR were conducted to examine the causal relationship between thyroid function and IBD and to explore the potential mechanisms underlying the associations.ResultsGenetically determined hypothyroidism significantly reduced the risk of CD (odds ratio [OR] = 0.761, 95% CI: 0.655–0.882, p < 0.001). Genetically determined reference-range TSH was found to have a suggestive causal effect on IBD (OR = 0.931, 95% CI: 0.888–0.976, p = 0.003), (Crohn disease) CD (OR = 0.915, 95% CI: 0.857–0.977, p = 0.008), and ulcerative colitis (UC) (OR =0.910, 95% CI: 0.830–0.997, p = 0.043). In reverse MR analysis, both IBD and CD appeared to have a suggestive causal effect on the fT3/fT4 ratio (OR = 1.002, p = 0.013 and OR = 1.001, p = 0.015, respectively). Among 41 cytokines, hypothyroidism had a significant impact on interferon-inducible protein-10 (IP-10) (OR = 1.465, 95% CI: 1.094–1.962, p = 0.010). The results of multivariable MR showed that IP-10 may mediate the causal effects of hypothyroidism with CD.ConclusionOur results suggest that an elevated TSH level reduces the risk of CD, with IP-10 potentially mediating this association. This highlights the pituitary-thyroid axis could serve as a potential therapeutic strategy for CD.

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Section: Discussionmentioning

confidence: 99%