Clinically relevant modeling of urodynamics function: The VBN model

Valentini, Françoise; Besson, G; Nelson, Peter G.

doi:10.1002/nau.22409

Cited by 17 publications

(12 citation statements)

References 29 publications

(31 reference statements)

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“…The VBN software version VBN 2012 in Linux was used to establish these tables and is available upon request. An example of these basic tables is given in Table .…”

Section: Resultsmentioning

confidence: 99%

“…These mechanical parameters vary neither during a urodynamic session nor within a short follow‐up in the absence of an external intervention. Using the VBN mathematical model of micturition, analysis of a pressure‐flow study (PFs) tracing can be performed to derive the value of these two important parameters, namely k for the detrusor force (or detrusor contractility) and U for urethral compression. However, the VBN method of curve fitting to extract these two parameters is somewhat time consuming and requires some basic training with the model as outlined in a prior review …”

Section: Introductionmentioning

confidence: 99%

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VBN‐based nomograms provide critical voiding parameters which can be used for invasive or non‐invasive flow interpretation of women at risk of obstruction over time

Valentini

Nelson

2015

Neurourology and Urodynamics

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“…The VBN software version VBN 2012 in Linux was used to establish these tables and is available upon request. An example of these basic tables is given in Table .…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

VBN‐based nomograms provide critical voiding parameters which can be used for invasive or non‐invasive flow interpretation of women at risk of obstruction over time

Valentini

Nelson

2015

Neurourology and Urodynamics

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“…In a second step, the VBN mathematical micturition model (9,10) was used to analyze the main part of the voiding phase and to test pathophysiological hypotheses able to explain the occurrence of DAC.…”

Section: Methodsmentioning

confidence: 99%

2268 Detrusor After-Contraction. New Insight

Valentini¹,

Nelson²

2013

Journal of Urology

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ARTICLE INFO ______________________________________________________________ ______________________Aims: Detrusor after-contractions (DAC) are non-common in adults. Both definition (nothing in ICS reports) and significance (artefact, link with detrusor overactivity (DO) or bladder outlet obstruction (BOO)) remain discussed. Our purpose was to carry out an analysis of the urodynamic parameters during voidings with DAC and, using the VBN model, to simulate pathophysiological conditions able to explain both voiding phase and DAC. Materials and Methods: From large urodynamic database of patients referred for evaluation of lower urinary tract dysfunction, DAC were observed in 60 patients (5.7%).Criteria for DAC were post-void residual <30mL and increase of detrusor pressure >10cmH 2 O. VBN model was used for analysis of both pressure and flow curves, and simulations of pathophysiological conditions. Results: Onset of DAC (ODAC) occurred when Q=7.3±5.7mL/s and bladder volume=17.9±15.4mL. Urgency-frequency syndrome and urodynamic diagnosis of DO were the more frequent scenarios associated with DAC. ODAC was associated to an inversion of the slope of detrusor pressure curve without any perturbation in flow curve. Among tested pathophysiological hypothesis (great, abnormal, detrusor force, sphincter contraction), none allowed restoring all recorded curves (flow rate, voiding pressure and DAC). Conclusion:No urodynamic characteristic of the first part of voiding is an index of occurrence of DAC. ODAC is a significant phenomenon linked with the bladder collapse. DAC is not associated with BOO but more probably with DO and appears as the result of local conditions in an almost empty bladder (concentration of stresses around a transducer); thus DAC seems of weak clinical significance.

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“…However, Q max and p detQmax are dependent upon the initial bladder volume . VBN allows tabulation of Q max and p detQmax against k and U (the variables for contractility and obstruction respectively in the VBN (Valentini, Besson, Nelson) model).…”

Section: Bladder Mechanics and Modellingmentioning

confidence: 99%

Recommendations for future development of contractility and obstruction nomograms for women. ICI-RS 2014

Rademakers

Apostolidis

Constantinou

et al. 2016

Neurourol. Urodynam.

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Based on the think tank discussion, the ICI-RS panel put forward the following recommendations: the need to acquire normative age-matched data in women to define "normal" and "pathological" values of urodynamic parameters; the inclusion of additional clinical data in new nomograms and the use of this extra dimension to develop clinically applicable nomograms for female BOO and contractility; and finally, the need to take into account the variability of BOO in women when developing female bladder contractility nomograms.

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Clinically relevant modeling of urodynamics function: The VBN model

Abstract: Because the process of fitting model computations and real recordings is a powerful way to detect unexpected phenomena, the use of the VBN model provides a method to improve the knowledge of misunderstood dysfunctions of the lower urinary tract.

Cited by 17 publications

References 29 publications

VBN‐based nomograms provide critical voiding parameters which can be used for invasive or non‐invasive flow interpretation of women at risk of obstruction over time

VBN‐based nomograms provide critical voiding parameters which can be used for invasive or non‐invasive flow interpretation of women at risk of obstruction over time

2268 Detrusor After-Contraction. New Insight

Recommendations for future development of contractility and obstruction nomograms for women. ICI-RS 2014

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