Clinical variables related to suicide attempts in schizophrenic patients: a retrospective study

Altamura, Alfredo Carlo; Bassetti, Roberta; Bignotti, Stefano; Pioli, Rosaria; Mundo, Emanuela

doi:10.1016/s0920-9964(02)00164-0

Cited by 112 publications

(83 citation statements)

References 33 publications

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“…This worse outcome includes a poorer response to antipsychotic medications, the presence of more severe symptoms (e.g. both negative and cognitive, referring to schizophrenia) [47,48,49], more frequent recurrences and hospitalizations, and higher suicide risk [47,50,51,52,53]. …”

Section: Resultsmentioning

confidence: 99%

Can Long-Term Outcomes Be Improved by Shortening the Duration of Untreated Illness in Psychiatric Disorders? A Conceptual Framework

et al. 2012

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The duration of untreated illness (DUI), meaning the latency to the pharmacological treatment, has been increasingly investigated in the last decade as a predictor of outcome across different psychiatric conditions, particularly in psychotic disorders. DUI is essentially computed by subtracting the age of onset of a specific disorder from the age at which the first adequate pharmacological treatment is administered. Assessment of the latency to treatment represents one of the first steps in planning early interventions. This review examines the role of the DUI in psychotic and affective disorders, focusing on neuropathological, epidemiologic, clinical and prognostic factors related to a longer latency to treatment. Through a Medline and Cochrane Library search, relevant studies up to June 2011 and other pertinent articles including meta-analyses, randomized controlled trials, naturalistic studies and clinical reviews were identified. Converging evidence indicates that a prolonged DUI negatively influences the outcome of first-episode psychosis and schizophrenia in different ways, and increasing data point toward a similar conclusion in affective disorders. Even though methodological limitations related to investigation of the DUI need to be considered, research and interventions aimed to reduce latency to treatments are object of increasing implementation worldwide. The assessment of the DUI represents one of the most important parameters to consider in this perspective, in order to quantify different latency to treatment in specific disorders and to plan related, targeted interventions.

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Section: Resultsmentioning

confidence: 99%

Can Long-Term Outcomes Be Improved by Shortening the Duration of Untreated Illness in Psychiatric Disorders? A Conceptual Framework

et al. 2012

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“…These include increased thought disorder (Bakst et al, 2010), increased insight into illness (Barrett, Sundet, Faerden, Agartz, et al, 2010;Lopez-Morinigo, Ramos-Rios, David, & Dutta, 2012;Robinson et al, 2009), longer duration of untreated illness (Altamura, Bassetti, Bignotti, Pioli, & Mundo, 2003), and negative beliefs about psychosis (Barrett, Sundet, Faerden, Agartz, et al, 2010). Research conducted into suicide risk in the very early stages of psychosis prior to first presentation to services has found that, in addition to the above-mentioned risk factors, younger age at onset and longer duration of untreated psychosis are associated with increased risk of DSH and suicidal ideation before first presentation (Altamura et al, 2003;Barrett, Sundet, Faerden, Nesvag, et al, 2010;Clarke et al, 2006;Harvey et al, 2008).…”

Section: Risk Factors For Suicidementioning

confidence: 99%

“…Research conducted into suicide risk in the very early stages of psychosis prior to first presentation to services has found that, in addition to the above-mentioned risk factors, younger age at onset and longer duration of untreated psychosis are associated with increased risk of DSH and suicidal ideation before first presentation (Altamura et al, 2003;Barrett, Sundet, Faerden, Nesvag, et al, 2010;Clarke et al, 2006;Harvey et al, 2008).…”

Section: Risk Factors For Suicidementioning

confidence: 99%

Future‐directed thinking in first‐episode psychosis

Goodby

MacLeod

2015

British J Clinic Psychol

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ObjectivesThis study employed the Future Thinking Task (MacLeod et al., 2005, Br. J. Clin. Psychol., 44, 495) to investigate whether future‐directed thinking in first‐episode psychosis is significantly different from that of matched controls, and to identify its correlates in this patient group.DesignCross‐sectional, mixed‐model, case–control design.MethodParticipants were 30 patients with first‐episode psychosis and 27 matched controls. The Future Thinking Task was used to assess future‐directed thinking in both groups. Anxiety and depression were also measured as well as self‐report measures of hopelessness, suicide ideation and a measure of negative symptoms.ResultsIndividuals with psychosis were impaired in future‐directed thinking in both positive and negative domains, particularly with respect to the coming year. Increased self‐reported hopelessness was associated with reduced positive future thinking and increased negative future thinking. Increased positive future thinking was also associated with reduced severity of negative symptoms, whilst negative future thinking was associated with suicide ideation.ConclusionsIndividuals with first‐episode psychosis show a reduction in positive future thinking in line with that seen in other clinical groups, but this is accompanied by an unexpected reduction in negative future thinking. The findings suggest a general disengagement with the future in this group that may affect recovery and functioning.Practitioner points Individuals with first‐episode psychosis may benefit from interventions to help them engage with their future, in particular in the mid‐range, up to 1 year. The Future Thinking Task may be a helpful addition to the assessment of suicide risk in those with first‐episode psychosis. Decreased positive future thinking was associated with increased severity of negative symptoms, indicating a potential new treatment angle for this resistant aspect of psychosis. The cross‐sectional design of this study does not allow for conclusions about the causal relationship between psychosis and future‐directed thinking. This study investigated future‐directed thinking in individuals with a range of psychotic illnesses employing a trans‐diagnostic approach; therefore, conclusions cannot be drawn about the nature of future‐directed thinking in individual psychotic disorders.

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“…To our knowledge, very few studies have investigated the activity of paraoxonase in suicidal patients; Zhang et al showed a decrease in PON1 activity in Chinese suicidal patients followed for psychiatric disorders. The sAmel team also found an association between exposure to pesticides, decreased activity of PON1 and the onset of suicidal ideation [24].…”

Section: Discussionmentioning

confidence: 94%

Association between Paraoxonase 1 (PON1) and Suicidal Risk in Patients with Schizophrenia

Mensi¹,

Messaoud²,

Hellara³

et al. 2017

J Psychiatry

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Clinical variables related to suicide attempts in schizophrenic patients: a retrospective study

Cited by 112 publications

References 33 publications

Can Long-Term Outcomes Be Improved by Shortening the Duration of Untreated Illness in Psychiatric Disorders? A Conceptual Framework

Can Long-Term Outcomes Be Improved by Shortening the Duration of Untreated Illness in Psychiatric Disorders? A Conceptual Framework

Future‐directed thinking in first‐episode psychosis

Association between Paraoxonase 1 (PON1) and Suicidal Risk in Patients with Schizophrenia

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