Clinical Value of Carcinoembryonic Antigen

Jd, Beatty; Romero, C.; Pw, Brown; Lawrence, Walter; Jj, Terz

doi:10.1001/archsurg.1979.01370290013002

Cited by 51 publications

(2 citation statements)

References 24 publications

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“…Circulating CEA levels have been reported to correlate with the extent of colorectal disease [6]. These levels are elevated in approximately 75 % of patients with recurrent or advanced disease and are highest in those patients with widely disseminated disease especially that which involves the liver [7].…”

Section: Discussionmentioning

confidence: 99%

An unusual presentation of colon cancer

Morton

Scholes

Kral

1986

Journal of Surgical Oncology

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A rare case of asymptomatic cancer of the ascending colon presenting as a subcutaneous groin mass is reported. At the time of right hemicolectomy with resection of the groin mass there was no sign of incontinuity spread or lymph blockage. Sequential determination of carcinoembryonic antigen levels (CEA) in serum reflected the reduction in tumor mass after surgery as well as subsequent recurrences of disease in the groin and in the lung after 2 years. Immunoperoxidase staining of the primary tumor and the metastases showed strong positivity for CEA confirming the origin of the serum CEA. There have been no signs of liver involvement. The route of spread of this unusual metastasis is not known.

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Section: Discussionmentioning

confidence: 99%

An unusual presentation of colon cancer

Morton

Scholes

Kral

1986

Journal of Surgical Oncology

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“…ενδιάμεσων, που αντιστοιχεί στους καπνιστές και σε άτομ με διάφορες παθολογικές καταστάσεις μη καρκινοματώδεις , και γ) των υψηλών τιμών που αντιστοιχούν σε κακοήθειαBeatty et al (1979),Shuster et Al (1977) .Loewenstein et al(1976), σε ένα μεγάλο ποσοστό των αρρώστων πα ρουσιάζει υψηλές τιμές. Η εκτίμηση των επιπέδων του κυκλοφορούντος καρκινοεμβρυΐ'κού αντιγόνου στον ορό, συμφωνά με τις εργασίες που έχουν γίνει, φαίνεται ότι αποτελεί ένα ικανοποιητικό κρι τήριο της πορείας του αρρώστου με καρκίνο του πνεύμονα, ύπτερα από χειρουργική αφαίρεση, χημειοθεραπεία ή ακτινοθεραπεία, σε συνδυασμό με την λοιπή κλινικοεργαστηριακή παρακολούθησηGoslin et al (1981).…”

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Μελετη Του Καρκινοεμβρυικου Αντιγονου (Cea) Στον Ορο Και Το Εγκεφαλονωτιαιο Υγρο Σε Νεοπλασιες Του Κεντρικου Νευρικου Συστηματος

Ρομποσ¹

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Malignant Ascites

Aslam¹,

Marino²

2001

Arch Intern Med

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Malignant ascites is a manifestation of advanced malignant disease that is associated with significant morbidity. Mainstays of treatment include diuretics and recurrent large volume paracentesis. Although lymphatic obstruction has been considered the major pathophysiologic mechanism behind its formation, recent evidence suggests that immune modulators, vascular permeability factors, and metalloproteinases are contributing significantly to the process. These new observations offer the opportunity for development of new, more targeted therapies for the treatment of malignant ascites. This article uses a clinical case to highlight the problem, then reviews these new concepts in the pathophysiology of malignant ascites formation. The diagnosis and management of this challenging medical problem are subsequently discussed, with emphasis on how these new pathophysiologic insights are being applied to the development of novel therapies that may soon change how we manage this troubling clinical condition.

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Clinical Value of Carcinoembryonic Antigen

Cited by 51 publications

References 24 publications

An unusual presentation of colon cancer

An unusual presentation of colon cancer

Μελετη Του Καρκινοεμβρυικου Αντιγονου (Cea) Στον Ορο Και Το Εγκεφαλονωτιαιο Υγρο Σε Νεοπλασιες Του Κεντρικου Νευρικου Συστηματος

Malignant Ascites

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