Clinical value of a [18F]-FDG PET-CT muscle-to-muscle SUV ratio for the diagnosis of active dermatomyositis

Martis, N.; Viau, P.; Zénone, Thierry; Andry, F.; Grados, A.; Ebbo, Mikaël; Castela, E.; Brihaye, B.; Denis, E.; Liguori, Stéphane; Audemard, A.; Schoindre, Y.; Morin, Anne‐Sophie; Terrier, B.; Marcq, L.; Mounier, Nicolas; Lidove, Olivier; Chaborel, Jean-Philippe; Quinsat, D.

doi:10.1007/s00330-019-06302-9

Cited by 10 publications

(9 citation statements)

References 20 publications

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“…FDG PET imaging also permits to detect muscle inflammation, but normal values for muscle Standardized Uptake Value (SUV) are difficult to define (120)(121)(122)(123). The sensitivity for muscle inflammation is broad: 33-90% (120)(121)(122)124) in IIM depending on muscle inflammation definition (qualitative or quantitative definition).…”

Section: [18f] Fluorodeoxyglucose Positron Emission Tomography/computed Tomography (Fdg Pet)mentioning

confidence: 99%

MRI and muscle imaging for idiopathic inflammatory myopathies

et al. 2021

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Although idiopathic inflammatory myopathies (IIM) are a heterogeneous group of diseases nearly all patients display muscle inflammation. Originally, muscle biopsy was considered as the gold standard for IIM diagnosis. The development of muscle imaging led to revisiting not only the IIM diagnosis strategy but also the patients’ follow‐up. Different techniques have been tested or are in development for IIM including positron emission tomography, ultrasound imaging, ultrasound shear wave elastography, though magnetic resonance imaging (MRI) remains the most widely used technique in routine. Whereas guidelines on muscle imaging in myositis are lacking here we reviewed the relevance of muscle imaging for both diagnosis and myositis patients’ follow‐up. We propose recommendations about when and how to perform MRI on myositis patients, and we describe new techniques that are under development.

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Section: [18f] Fluorodeoxyglucose Positron Emission Tomography/computed Tomography (Fdg Pet)mentioning

confidence: 99%

MRI and muscle imaging for idiopathic inflammatory myopathies

et al. 2021

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“…The database search identified 252 records found and 236 records were excluded after title/abstract screening and full-text content because those did not provide any relevant information on the topic of this review (Figure 1). Sixteen articles were eligible for a more detailed description in this review (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31).…”

Section: Literature Search Study and Patient Characteristicsmentioning

confidence: 99%

“…Two studies used a ratio of SUV's with liver uptake as reference with optimal cut-off values of 0.45 and 0.66 yielding a sensitivity of 75% and 92% and a specificity of 100 and 89%, respectively (18,23). The study by Martis et al (25), evaluating the ratio of muscle uptake in limbs compared to the muscle uptake in the lumbar region, reported a moderate diagnostic accuracy with sensitivity of 50% and specificity of 83% using a cut-off value of 1.73. Finally, a head-to-head comparison between visual interpretation and semi-quantitative (SUVmax) indices in one study demonstrated a similar performance with AUC values of 0.90 and 0.89, respectively.…”

Section: Visual Assessmentmentioning

confidence: 99%

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The Role of Quantitative and Semi-quantitative [18F]FDG-PET/CT Indices for Evaluating Disease Activity and Management of Patients With Dermatomyositis and Polymyositis

2022

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Idiopathic inflammatory myopathies (IIM) are considered systemic diseases involving different organs and some subtypes are associated with increased cancer risk. In this review, we provide a comprehensive summary of the current use and potential applications of (semi-)quantitative [18F]FDG-PET/CT indices in patients with IIM focusing on dermatomyositis and polymyositis. Visual interpretation and (semi-)quantitative [18F]FDG-PET indices have a good overall performance to detect muscle activity but objective, robust and standardized interpretation criteria are currently lacking. [18F]FDG-PET/CT is a suitable modality to screen for malignancy in patients with myositis and may be a promising tool to detect inflammatory lung activity and to early identify patients with rapidly progressive lung disease. The latter remains to be determined in large, prospective comparative trials.

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“…So ist die Fluordesoxyglucose-PET (FDG-PET) in der Lage, einen deutlich erhöhten Muskelmetabolismus nachzuweisen, wie er unter anderem im Rahmen Inflammatorischer Myopathien besteht. In diesem Zusammenhang ist die PET sowohl zur Differenzierung zwischen einzelnen Subgruppen der Inflammatorischen Myopathien als auch in der Verlaufsuntersuchung untersucht worden 9 10 . Darüber hinaus können parallel zugrundeliegende Malignome (als Ursache einer Paraneoplasie) detektiert werden 11 .…”

Section: Bildgebende Verfahren Bei (Neuro-)muskulären Erkrankungenunclassified

Bildgebung der Muskulatur bei Neuromuskulären Erkrankungen – von der Initialdiagnostik bis zur Verlaufsbeurteilung

Mensch

Nägel

Zierz

et al. 2022

Klinische Neurophysiologie

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ZusammenfassungDie bildgebende Diagnostik hat sich zu einem integralen Element der Betreuung von PatientInnen mit neuromuskulären Erkrankungen entwickelt. Als wesentliches Diagnostikum ist hierbei die Magnetresonanztomografie als breit verfügbares und vergleichsweise standardisiertes Untersuchungsverfahren etabliert, wobei die Sonografie der Muskulatur bei hinreichend erfahrenem Untersucher ebenfalls geeignet ist, wertvolle diagnostische Informationen zu liefern. Das CT hingegen spielt eine untergeordnete Rolle und sollte nur bei Kontraindikationen für eine MRT in Erwägung gezogen werden. Zunächst wurde die Bildgebung bei Muskelerkrankungen primär in der Initialdiagnostik unter vielfältigen Fragestellungen eingesetzt. Das Aufkommen innovativer Therapiekonzepte bei verschiedenen neuromuskulären Erkrankungen machen neben einer möglichst frühzeitigen Diagnosestellung insbesondere auch eine multimodale Verlaufsbeurteilung zur Evaluation des Therapieansprechens notwendig. Auch hier wird die Bildgebung der Muskulatur als objektiver Parameter des Therapieerfolges intensiv diskutiert und in Forschung wie Praxis zunehmend verwendet.

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Clinical value of a [18F]-FDG PET-CT muscle-to-muscle SUV ratio for the diagnosis of active dermatomyositis

Cited by 10 publications

References 20 publications

MRI and muscle imaging for idiopathic inflammatory myopathies

MRI and muscle imaging for idiopathic inflammatory myopathies

The Role of Quantitative and Semi-quantitative [18F]FDG-PET/CT Indices for Evaluating Disease Activity and Management of Patients With Dermatomyositis and Polymyositis

Bildgebung der Muskulatur bei Neuromuskulären Erkrankungen – von der Initialdiagnostik bis zur Verlaufsbeurteilung

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