Clinical Validation of the Greek Version of the Acute Cystitis Symptom Score (ACSS)—Part II

Abstract

The Acute Cystitis Symptom Score (ACSS) is a patient self-reporting questionnaire for the clinical diagnosis and patient-reported outcome (PRO) in women with acute uncomplicated cystitis (AC). The aim of the current study (part II) is the clinical validation of the Greek ACSS questionnaire. After linguistic validation according to internationally accepted guidelines and cognitive assessment (part I), the clinical validation was performed by using the Greek ACSS study version in 92 evaluable female participants including 53 patients with symptoms suspicious of AC and 39 controls. The clinical outcome using the ACSS questionnaire at different points in time after the start of treatment was demonstrated as well. The age (mean ± SD) of the 53 patients (44.7 ± 17.0 years) and 39 controls (49.3 ± 15.9 years) and their additional conditions at baseline visits, such as menstruation, premenstrual syndrome, pregnancy, menopause, diabetes mellitus, were comparable. There was, however, a significant difference (p < 0.001) between patients and controls at baseline visit regarding sum score of the ACSS domains, such as typical symptoms and quality of life. The clinical outcome of up to 7 days showed a fast reduction of the symptom scores and improvement of quality of life. The optimal thresholds for the patient-reported outcome of successful therapy could be established. The linguistically and clinically validated Greek ACSS questionnaire can now be used for clinical or epidemiological studies and also for patients’ self-diagnosis of AC and as a PRO measure tool.

Linguistic and clinical validation of the Turkish version of Acute Cystitis Symptom Score for the diagnosis and patient-reported outcome in acute uncomplicated cystitis

“…The limitations of our study can be summarized as the relatively small number of patients, and to be performed in a single centre. However, our results are in agreement with those found with the ACSS translated and validated in other languages as well [ 2 14 15 18 19 20 24 25 ].…”

“…Similarly, no difference was noted between pre-treatment and post-treatment severity of symptoms and leucocyte-esterase test results. The lack of significant association between levels of bacteriuria and severity of symptoms at baseline as well as for clinical outcome as found in other studies correlates with our results concerning the amount of bacteriuria [ 24 25 ].…”

Polish version of the Acute Cystitis Symptom Score for patients with acute uncomplicated cystitis

“…At a cut-off of 6 and higher a median specificity of 97% was achieved, which was as high as at a cut-off of 7 and higher, but higher than at a cut-off of 5 and higher. However, the sensitivity at a cut-off of 6 and higher was only 79%, but this was similar to [ 27 ] or somewhat lower than other ACSS versions [ 10 , 28 ].…”

Prescription of Choreito, a Japanese Kampo Medicine, with Antimicrobials for Treatment of Acute Cystitis: A Retrospective Cohort Study

“…Therefore, attempts to reduce antibiotic use are important. As urinary tract infections are very frequent and affect one out of three women in their lifetime, antibiotics are frequently administered, and attempts to reduce the dosage of antibiotics for acute cystitis are highly significant [ 1 , 2 , 3 ].…”

“…Acute cystitis is the most frequent infection encountered in general clinical practice; approximately one in three women have been reported to experience urinary tract infections at least once in their lifetime [ 1 , 2 , 3 ]. Antibiotics are often used to treat acute cystitis.…”