Clinical utilization of shear wave dispersion imaging in diffuse liver disease

Sugimoto, Katsutoshi; Moriyasu, Fuminori; Oshiro, Hisashi; Takeuchi, Hirohito; Yoshimasu, Yu; Kasai, Yoshitaka; Itoi, Takao

doi:10.14366/usg.19031

Cited by 85 publications

(118 citation statements)

References 22 publications

(39 reference statements)

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“…But the common understanding is that viscosity in the human liver increases with higher fibrosis stages, as summarized in Table 6. Likewise, a recent study of Sugimoto et al [109] has tried to overcome the limitations of the former studies by enrolling subjects with a single etiology, and using the dispersion slope value instead of a simple Voigt model since there is no consensus in the clinical/elastography community with the most appropriate rheological model for soft tissue characterization. They put the focus of dispersion slope measurements on the lack of practical guidance.…”

Section: Livermentioning

confidence: 99%

Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?

Rus

Faris

Torres

et al. 2020

Sensors

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The adoption of multiscale approaches by the biomechanical community has caused a major improvement in quality in the mechanical characterization of soft tissues. The recent developments in elastography techniques are enabling in vivo and non-invasive quantification of tissues’ mechanical properties. Elastic changes in a tissue are associated with a broad spectrum of pathologies, which stems from the tissue microstructure, histology and biochemistry. This knowledge is combined with research evidence to provide a powerful diagnostic range of highly prevalent pathologies, from birth and labor disorders (prematurity, induction failures, etc.), to solid tumors (e.g., prostate, cervix, breast, melanoma) and liver fibrosis, just to name a few. This review aims to elucidate the potential of viscous and nonlinear elastic parameters as conceivable diagnostic mechanical biomarkers. First, by providing an insight into the classic role of soft tissue microstructure in linear elasticity; secondly, by understanding how viscosity and nonlinearity could enhance the current diagnosis in elastography; and finally, by compounding preliminary investigations of those elastography parameters within different technologies. In conclusion, evidence of the diagnostic capability of elastic parameters beyond linear stiffness is gaining momentum as a result of the technological and imaging developments in the field of biomechanics.

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Section: Livermentioning

confidence: 99%

Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?

Rus

Faris

Torres

et al. 2020

Sensors

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“…(2) In general, liver fibrosis increases gradually in parallel with the stage progression of chronic liver disease. However, shear waves propagate disproportionally as fibrosis progresses [22,25,[41][42][43]. Namely, SWD is increased in hepatitis patients, whereas SWD is decreased in cirrhosis patients (with grade 4 or 5 severe fibrosis) [41,44].…”

Section: Discussionmentioning

confidence: 99%

“…Although SWE reflects both elasticity and viscosity (i.e., viscoelasticity) [22]. SWD is calculated based on SWD measurements and reflects viscosity only [24,25]. Since liver fibrosis advances gradually as hepatitis progresses [26], SWD may be able to estimate liver damage in an earlier stage than SWE.…”

Section: Introductionmentioning

confidence: 99%

Shear Wave Dispersion Predicts Liver Fibrosis and Adverse Outcomes in Patients with Heart Failure

Ohara

Yoshihisa

Ishibashi

et al. 2020

JCM

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Background: It has been recently reported that liver stiffness assessed by transient elastography reflects right atrial pressure (RAP) and is associated with worse outcomes in patients with heart failure (HF). However, the relationship between shear wave dispersion (SWD, a novel indicator of liver viscosity) determined by abdominal ultrasonography and RAP, and the prognostic impact of SWD on HF patients have not been fully examined. We aimed to clarify the associations of SWD with parameters of liver function test (LFT) and right heart catheterization (RHC), as well as with cardiac events such as cardiac death and worsening HF, in patients with HF. Methods: We performed abdominal ultrasonography, LFT and RHC in HF patients (n = 195), and followed up for cardiac events. We examined associations between SWD and parameters of LFT and RHC. Results: There were significant correlations between SWD and circulating levels of direct bilirubin (R = 0.222, p = 0.002), alkaline phosphatase (R = 0.219, p = 0.002), cholinesterase (R = −0.184, p = 0.011), and 7S domain of collagen type IV (R = 0.177, p = 0.014), but not with RAP (R = 0.054, p = 0.567) or cardiac index (R = −0.015, p = 0.872). In the Kaplan–Meier analysis, cardiac event rate was significantly higher in the high SWD group (SWD ≥ 10.0 (m/s)/kHz, n = 103) than in the low SWD group (SWD < 10.0 (m/s)/kHz, n = 92; log-rank, p = 0.010). In the Cox proportional hazard analysis, high SWD was associated with high cardiac event rates (hazard ratio, 2.841; 95% confidence interval, 1.234–6.541, p = 0.014). In addition, there were no interactions between SWD and all subgroups, according to the subgroup analysis. Conclusions: SWD assessed by abdominal ultrasonography reflects liver fibrosis rather than liver congestion, and is associated with adverse prognosis in HF patients.

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“…Finally, from shear wave speed and frequency, SWD can be estimated as a phase domain, and is calculated in units of (m/sec)/kHz [8,11]. Since 2D-SWI was introduced, several preliminary studies have reported the clinical significance of SWD in various hepatic diseases, both in a rat model and in human patients [8,11,21,22]. To our knowledge, this is the first study to evaluate secondary changes in the liver by 2D-SWI, focusing on the GB.…”

Section: Discussionmentioning

confidence: 99%

Added value of 2D shear wave imaging of the gallbladder bed of the liver for acute cholecystitis

Lee

Park

et al. 2020

Ultrasonography

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Epub ahead of printPurpose: The purpose of this study was to evaluate whether shear wave elastography (SWE) and the shear wave dispersion slope (SWD) obtained from 2-dimensional shear wave imaging (2D-SWI) of the gallbladder (GB) bed of the liver could be helpful in the diagnosis of acute cholecystitis. Methods: We included 44 patients referred for abdominal ultrasonography (US) under the impression of acute cholecystitis from April 2018 to March 2019. Patients with chronic liver disease were excluded from this study. In addition to routine upper abdominal US, we performed 2D-SWI including liver stiffness measurements by SWE and SWD, which reflects tissue viscosity. 2D-SWI was performed at the GB bed of the liver through the right intercostal approach at least 3 times with different frames. We assessed typical US findings and the added value of 2D-SWI in diagnosing acute cholecystitis. Histopathologic results of surgical specimens were used as the standard of reference. If a surgical specimen was unavailable, a bile fluid test or clinical followup for more than 3 months served as the reference standard. Results: The optimal cutoff values for SWE and SWD were 8 kPa and 10.9 (m/sec)/kHz, respectively. In the univariate analysis, SWE, GB distension, and sludge were predictive factors of acute cholecystitis. In the multivariate analysis, categorized SWE was the only significant predictor (P<0.01). By using 2D-SWI, the diagnostic performance of two readers did not significantly increase, although the inter-reader agreement improved (k=0.654-0.778). Conclusion: 2D-SWI of the GB bed of the liver could be helpful for diagnosing acute cholecystitis.

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Clinical utilization of shear wave dispersion imaging in diffuse liver disease

Cited by 85 publications

References 22 publications

Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?

Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?

Shear Wave Dispersion Predicts Liver Fibrosis and Adverse Outcomes in Patients with Heart Failure

Added value of 2D shear wave imaging of the gallbladder bed of the liver for acute cholecystitis

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