Clinical utility of vascular endothelial growth factor in diagnosing malignant pleural effusions

Shu, Jun; Sun, Guibo; Liu, Jing

doi:10.1080/02841860701280733

Cited by 13 publications

(12 citation statements)

References 21 publications

(21 reference statements)

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“…A diagnostic accuracy meta‐analysis concerning serum VEGF levels in order to assess a summary specificity and sensitivity could not be performed with the present data since there were only two studies examining the sensitivity and specificity of the biomarker (Shu et al. ; Zhang et al. ).…”

Section: Discussionmentioning

confidence: 97%

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Systematic review and meta‐analysis of vascular endothelial growth factor as a biomarker for malignant pleural effusions

Fafliora

Hatzoglou

Gourgoulianis

et al. 2016

Physiological Reports

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Conventional methods may fail to identify the cause of pleural effusion (PE), thus establishing reliable biomarkers is deemed necessary. This study aimed at examining the role of vascular endothelial growth factor (VEGF) as a biomarker in the differentiation between malignant and benign PEs in adults. A comprehensive literature search in PubMed (Medline), Scopus (ELSEVIER), and Cochrane Central Register of Controlled Trials (CENTRAL) databases was conducted using keywords. We included studies that evaluated pleural and/or serum levels of VEGF among patients presenting with undiagnosed PE and the association between these levels and the final diagnosis. We performed a meta‐analysis to calculate the summary effect using the random effects model. Statistical analysis was performed with the statistical package for meta‐analysis Comprehensive Meta‐Analysis. Twenty studies were included in the systematic review, while 11 of them in the meta‐analysis. Pleural fluid VEGF levels among patients with malignant PE were increased by 1.93 ng/mL as compared to patients with benign PE (95% CI: 1.32–2.54, Q = 173, df (Q): 10, I 2 = 94.2%, P < 0.05). Serum VEGF levels among patients with malignant PE were increased respectively by 1.90 ng/mL (95% CI: 0.93–2.88, Q = 182, df (Q): 6, I 2 = 96.7%, P < 0.05). This study showed that malignant PEs were associated with higher levels of both pleural fluid and serum VEGF. VEGF appears to represent a promising biomarker for the differential diagnosis between benign and malignant PEs.

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Section: Discussionmentioning

confidence: 97%

“…Therefore, in a variety of malignancies, VEGF is overexpressed and thus the PF‐VEGF and/or S‐VEGF levels in MPE may be increased compared to BPE (Shu et al. ; Bradshaw et al. ).…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta‐analysis of vascular endothelial growth factor as a biomarker for malignant pleural effusions

Fafliora

Hatzoglou

Gourgoulianis

et al. 2016

Physiological Reports

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“…Previous studies have reported higher levels of VEGF in pleural effusions of malignant origin (34,35). Thickett et al in a prospective, long-term follow-up study of 78 patients with pleural effusions have shown that VEGF levels were increased in malignancy, empyemas and parapneumonic pleural effusions (29).…”

Section: Discussionmentioning

confidence: 99%

A potential role for VEGF in the diagnostic approach of pleural effusions

et al. 2016

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“…In malignant serous membrane effusions, expression of the above-mentioned angiogenesis-related factors may be significantly increased. Recent studies have shown that the expression levels of VEGF and angiopoietin-2 in malignant pleura effusions are markedly elevated compared to benign pleural effusions, and this can be helpful in the differential diagnosis between benign and malignant pleural effusion [11,12,13,14,15,16,17,18]. To date there have been no studies on whether the expression levels of VEGF and HIF-1α in pericardial effusions show similar characteristics.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Investigation of the Clinical Value of Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor-1α in Pericardial Fluid in Diagnosing Malignant and Tuberculous Pericardial Effusion

Liu

Zeng²,

Ma³

et al. 2010

Cardiology

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Objectives: To investigate the clinical value of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) in diagnosing malignant and tuberculous pericardial effusion. Methods: Eighty patients with exudative pericardial effusion undergoing pericardiocentesis and drainage were divided into 2 groups, namely those with malignancy and those with tuberculosis. The levels of HIF-1α, VEGF, lactate dehydrogenase (LDH) and adenosine deaminase (ADA) in pericardial fluid and serum were measured. Routine and cytological examination of pericardial fluid, clinical characteristics and some blood parameters were compared between the 2 groups. Results: There were 33 patients with tuberculous pericardial effusion and 47 with malignant pericardial effusion. The levels of VEGF and HIF-1α in pericardial fluid in the malignancy group were significantly higher than those in the tuberculosis group (p < 0.01), and there was a moderate positive correlation between the levels of VEGF and HIF-1α (r = 0.79, p < 0.01). The sensitivity and specificity of combining VEGF and HIF-1α were 90.8 and 88.3%, respectively. The 2 groups showed no differences with regard to gender distribution, occurrence of fever, erythrocyte sedimentation rate or the levels of hemoglobin, LDH, ADA, serum HIF-1α and VEGF. Conclusions: Both VEGF and HIF-1α in pericardial fluid have determinative value in the differential diagnosis of malignant and tuberculous pericardial effusion.

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Clinical utility of vascular endothelial growth factor in diagnosing malignant pleural effusions

Cited by 13 publications

References 21 publications

Systematic review and meta‐analysis of vascular endothelial growth factor as a biomarker for malignant pleural effusions

Systematic review and meta‐analysis of vascular endothelial growth factor as a biomarker for malignant pleural effusions

A potential role for VEGF in the diagnostic approach of pleural effusions

Preliminary Investigation of the Clinical Value of Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor-1α in Pericardial Fluid in Diagnosing Malignant and Tuberculous Pericardial Effusion

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