Clinical Utility of Urinary Antigen Detection for Diagnosis of Community-Acquired, Travel-Associated, and Nosocomial Legionnaires' Disease

Helbig, Jörg; Uldum, Søren A.; Bernander, Sverker; Lück, Paul Christian; Wewalka, G.; Abraham, Bill; Gaia, Valéria; Harrison, Timothy G.

doi:10.1128/jcm.41.2.838-840.2003

Cited by 149 publications

(102 citation statements)

References 18 publications

(9 reference statements)

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“…1). Helbig et al (2003) found an overall sensitivity of 80.6 % for the Binax EIA, which is in accordance with our result. Yzerman et al (2002) found a sensitivity of 69 % for Binax EIA and 72 % for BinaxNOW for unconcentrated urine samples, but an increase in sensitivity of approximately 10 % for concentrated samples.…”

Section: Discussionsupporting

confidence: 82%

Immunochromatic kits Xpect Legionella and BinaxNOW Legionella for detection of Legionella pneumophila urinary antigen have low sensitivities for the diagnosis of Legionnaires’ disease

Svarrer

Lück

Elverdal

et al. 2012

Journal of Medical Microbiology

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Urinary antigen tests are the most widely used methods for diagnosing Legionnaires' disease (LD). However, all available urinary antigen tests have the disadvantage that they have low or no sensitivity for serogroups (sgs) other than Legionella pneumophila sg 1. Recently, Oxoid introduced the Xpect Legionella test for detection of L. pneumophila sg 1 and sg 6. In this study, we have evaluated the Xpect kit together with the BinaxNOW kit and compared them with the Binax EIA kit. One hundred and fifteen urine samples from 91 patients with laboratory-confirmed LD were examined. Ninety-three samples were from 69 culture-proven cases of which 27 samples were from 23 non-sg 1 cases. At the patient level, the overall sensitivities for the three Legionella urinary antigen kits were 79 % for the Binax EIA, 47 % for the BinaxNOW and 32 % for the Xpect kit. None of the urine samples from the 10 L. pneumophila sg 6 cases were positive by the Xpect kit whereas samples from four of the patients were positive by the Binax EIA. Overall, the sensitivities for both immunochromatic assays were poor and they should not be used as the sole method for the diagnosis of LD.

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Section: Discussionsupporting

confidence: 82%

Immunochromatic kits Xpect Legionella and BinaxNOW Legionella for detection of Legionella pneumophila urinary antigen have low sensitivities for the diagnosis of Legionnaires’ disease

Svarrer

Lück

Elverdal

et al. 2012

Journal of Medical Microbiology

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“…A vast majority of community‐acquired LP cases are caused by this species and serogroup 4, 17, 18. Although it is very useful to define a diagnosis of LP, it is of limited use to detect non‐serogroup 1 L. pneumophila and other species.…”

Section: Discussionmentioning

confidence: 99%

Can we truly rely on the urinary antigen test for the diagnosis? Legionella case report

Miyata

Huh²,

Ito

et al. 2017

J of Gen and Family Med

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It is critical to diagnose and treat Legionella pneumonia (LP) immediately after infection because of the associated high mortality. The urine antigen test (UAT) is often used for the diagnosis of LP; however, it cannot detect the serogroups of all Legionella species. A detained medical history and several clinical findings such as liver enzyme elevation and hyponatremia are useful in diagnosis. Some specific types of Legionella are found in compost. Herein, we report a case of LP in which the patient's medical history and several clinical findings were useful for diagnosis.

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“…The PUatg is widely used and increases the number of etiologic diagnosis 14,15,16 . In our setting the sensitivity was 36% (CI 95% 10-62), conferring the test low precision in diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…In what concerns the use of PUatg in Healthcare Associated Pneumonias (HCAP), the evidence in literature is scarce, its usefulness in this context is controversial and the main societies don't recommend it [15][16][17] . However, in clinical practice, the test is frequently requested, so we decided to include these patients to clarify the role of the PUatg in this population.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Usefulness of Streptococcus pneumoniae Urinary Antigen in Patients Hospitalized with Non-Nosocomial Pneumonia

Ferreira¹,

Abreu²,

Rodrigues³

et al. 2012

IJIM

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Clinical Utility of Urinary Antigen Detection for Diagnosis of Community-Acquired, Travel-Associated, and Nosocomial Legionnaires' Disease

Cited by 149 publications

References 18 publications

Immunochromatic kits Xpect Legionella and BinaxNOW Legionella for detection of Legionella pneumophila urinary antigen have low sensitivities for the diagnosis of Legionnaires’ disease

Immunochromatic kits Xpect Legionella and BinaxNOW Legionella for detection of Legionella pneumophila urinary antigen have low sensitivities for the diagnosis of Legionnaires’ disease

Can we truly rely on the urinary antigen test for the diagnosis? Legionella case report

Clinical Usefulness of Streptococcus pneumoniae Urinary Antigen in Patients Hospitalized with Non-Nosocomial Pneumonia

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