Clinical utility of blood neutrophil-lymphocyte ratio in Japanese COPD patients

Sakurai, Kaori; Chubachi, Shotaro; Irié, Hiroyuki; Tsutsumi, Atsushi; Kameyama, Naofumi; Kamatani, Takashi; Koh, Hidefumi; Terashima, Takeshi; Nakamura, Hidetoshi; Asano, Koichiro; Betsuyaku, Tomoko

doi:10.1186/s12890-018-0639-z

Cited by 24 publications

(22 citation statements)

References 50 publications

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“…With a different perspetcive, in a study was found the level of NLR similar in COPD and ACO patients (35). In another study found that the NLR ratio increased in parallel with the severity of COPD (36). Similar results were found in our study.…”

Section: Discussionsupporting

confidence: 87%

Human Neutrophil Gelatinase-Associated Lipocalin: A New Biomarker in Asthma-COPD Overlap Syndrome

Serap

UÇAR

Kurt

2021

Preprint

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AIM Human neutrophil gelatinase-associated lipocalin (NGAL) is a protein considered as a noninvasive prognostic biomarker in Asthma-COPD overlap syndrome (ACO). In this study we aimed to show the usability of NGAL as a biomarker in ACO characterized with airway inflammation. MATERIAL-METHOD: Three patient groups (Group I: COPD, n: 50, Group II: Asthma, n:50, Group III: ACO, n:50) and a healhty non smoker group (Group IV, n:50) are taken into study. The serum NGAL levels of groups are compared. In addition, in Group I,II,III the level of serum NGAL is compared with the age, duration of smoking (pocket/year), number of attack per year, respiratory function values, serum C reaktive protein (CRP, mg/dL), serum IgE (IU/mL), serum neutrophil (%) and serum lymphocyte (%), blood neutrophil-to-lymphocyte rate and atopy. FINDINGS: In patients having ACO when the maximum level of serum exist, it is observed that serum NGAL level is increased as the number of attacks is increased (p = 0.002). On the other hand in the patients having ACO there was also positive correlation between NLR and serum NGAL level (p < 0.05). There was no other relation found among the other variables. CONCULISION: In the chronic inflamatuar lung diseases the findings of increase in serum NGAL levels while the severity of the disease suggest us serum NGAL levels might be used as a biomarker for evaluating the inflammation.

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Section: Discussionsupporting

confidence: 87%

Human Neutrophil Gelatinase-Associated Lipocalin: A New Biomarker in Asthma-COPD Overlap Syndrome

Serap

UÇAR

Kurt

2021

Preprint

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“…Savchenko et al and Sakurai et al found that FEV1 was negatively correlated with the systemic inflammatory factor IL-26 [52], a biomarker of inflammation. The neutrophil-to-lymphocyte ratio (NLR) is associated with the severity of COPD [53]. Inflammatory factor ‘spill-over’ [54] may cause cognitive impairment in COPD patients.…”

Section: Discussionmentioning

confidence: 99%

Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits

Yin

Wang

et al. 2019

BMC Pulm Med

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BackgroundTo explore patterns of brain structural alteration in chronic obstructive pulmonary disease (COPD) patients with different levels of lung function impairment and the associations of those patterns with cognitive functional deficits using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analyses based on high-resolution structural MRI and diffusion tensor imaging (DTI).MethodsA total of 115 right-handed participants (26 severe, 29 moderate, and 29 mild COPD patients and a comparison group of 31 individuals without COPD) completed tests of cognitive (Montreal Cognitive Assessment [MoCA]) and pulmonary function (forced expiratory volume in 1 s [FEV1]) and underwent MRI scanning. VBM and TBSS analyses were used to identify changes in grey matter density (GMD) and white matter (WM) integrity in COPD patients. In addition, correlation analyses between these imaging parameter changes and cognitive and pulmonary functional impairments were performed.ResultsThere was no significant difference in brain structure between the comparison groups and the mild COPD patients. Patients with moderate COPD had atrophy of the left middle frontal gyrus and right opercular part/triangular part of the inferior frontal gyrus, and WM changes were present mainly in the superior and posterior corona radiata, corpus callosum and cingulum. Patients with severe COPD exhibited the most extensive changes in GMD and WM. Some grey matter (GM) and WM changes were correlated with MoCA scores and FEV1.ConclusionsThese findings suggest that patients with COPD exhibit progressive structural impairments in both the GM and the WM, along with impaired levels of lung function, highlighting the importance of early clinical interventions.

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“…Other authors, Lee et al [3], Halper-Stromberg et al [19], and Sakuri et al [20], showed that the NLR values were higher in COPD compared to the control and positively correlated with the severity of the disease. Our results differ in the most severe stage of the disease, and this may be related to the appearance of a specific response related to the chronicity of the disease.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the level of selected parameters of inflammation, circulating immune complexes, and related indicators (neutrophil/lymphocyte, platelet/lymphocyte, CRP/CIC) in patients with obstructive diseases

Pilaczyńska-Cemel¹,

Gołda²,

Da̧browska³

et al. 2019

cejoi

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IntroductionChronic obstructive pulmonary disease (COPD) is an inflammatory disorder of the airways. An important element of COPD assessment is the evaluation of immune mechanisms involved in non-specific and specific response to ongoing inflammation.Aim of the studyTo evaluate the level of selected inflammatory and immunological parameters in patients with COPD, including C-reactive protein (CRP) and circulating immune complexes (CIC), as well as CRP/CIC index.Material and methodsThe study group consisted of 49 patients with obstructive pulmonary diseases (COPD, asthma, and asthma-COPD overlap syndrome) hospitalised in the Department of Pulmonary Diseases, Kuyavian-Pomeranian Pulmonology Centre in Bydgoszcz. Patients with COPD were divided into two subgroups, taking into account the severity of the disease according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD; stages B and D). The control group consisted of 30 healthy persons. Levels of CIC were determined by the method of Hasková, and the concentration of CRP in serum by the standard immunoturbidimetric method.ResultsThe median values of examined parameters (neutrophils, lymphocytes, platelets, neutrophil/lymphocyte ratio – NLR, platelet/lymphocyte ratio – PLR, CRP, CIC, and CRP/CIC index) were significantly higher among patients with obstructive diseases than in the control group. A tendency towards higher lymphocyte count, CRP, and CRP/CIC index in COPD stage D, compared to stage B, was observed.ConclusionsBased on our results, we suggest that the role of non-specific inflammatory mechanisms may increase in more advanced COPD stages (D), compared to less advanced stages (B).

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Clinical utility of blood neutrophil-lymphocyte ratio in Japanese COPD patients

Cited by 24 publications

References 50 publications

Human Neutrophil Gelatinase-Associated Lipocalin: A New Biomarker in Asthma-COPD Overlap Syndrome

Human Neutrophil Gelatinase-Associated Lipocalin: A New Biomarker in Asthma-COPD Overlap Syndrome

Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits

Analysis of the level of selected parameters of inflammation, circulating immune complexes, and related indicators (neutrophil/lymphocyte, platelet/lymphocyte, CRP/CIC) in patients with obstructive diseases

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