Clinical usefulness of epicardial adipose tissue in patients with high-intermediate pre-test probability for coronary artery disease

Zehi̇r, Regayip; Güner, Ahmet; Hayıroğlu, Mert İlker; Öz, Tuğba Kemaloğlu; Ösken, Altuğ; Aksu, Hüseyin; Dayı, Şennur Ünal; Hobikoglu, Gultekin

doi:10.5603/kp.a2018.0054

Cited by 5 publications

(7 citation statements)

References 23 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, epicardial adipose tissue quality and quantity (thickness) is related with CAD and may help in risk stratification. [7] We found no differences in the expressions of the following genes between both fat depots: Angiotensinogen, Glucagon-Like-Peptide Receptors type 1 and 2, Phospholipid Transfer Protein, Adiponectin and Uncoupling Protein-1. Given the patients characteristics, we found that diabetes was associated with increased UCP-1 and AGT in PVAT-IMA.…”

Section: Discussionmentioning

confidence: 53%

“…[3] However, the perivascular adipose tissue (PVAT) releases adipokines and other relaxing genes. [4,5] Visceral and epicardial adiposity revealed closer association with cardiovascular (CV) risk compared to subcutaneous fat accumulation, [6,7] possibly due to the stronger immune cell infiltration and higher expression of proinflammatory cytokines in this adipose tissue depot. [8] Although recent papers suggested an important role of (PVAT) in arterial atherosclerosis, the internal mammary artery (IMA) is the exception and shows nearly no atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Perivascular adipose tissue from the internal mammary artery in patients with severe coronary artery atherosclerosis

Kowalówka¹,

Machnik²,

Deja³

et al. 2020

Kardiol Pol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Perivascular adipose tissue from the internal mammary artery in patients with severe coronary artery atherosclerosis

Kowalówka¹,

Machnik²,

Deja³

et al. 2020

Kardiol Pol

View full text Add to dashboard Cite

show abstract

“…Thirty-one studies were excluded for various reasons after reviewing the original text. In 13 studies, the EFT had been measured using a tool other than echocardiography, or CAD had been detected by a non-angiographic method ( 14 – 26 ). In 8 studies, the parameters required to enter meta-analysis were not reported ( 27 – 34 ).…”

Section: Resultsmentioning

confidence: 99%

Is echocardiographic epicardial fat thickness increased in patients with coronary artery disease? A systematic review and meta-analysis

et al. 2018

View full text Add to dashboard Cite

BackgroundThe relation of epicardial fat thickness (EFT) to coronary artery disease (CAD) has recently been reported in multiple studies. Echocardiography is a safe and relatively inexpensive and accessible approach to assess regional EFT, which can be performed easily in many centers.ObjectiveTo determine the association between echocardiographic EFT and the presence or the absence of CAD.MethodsThis was a systematic review and meta-analysis conducted on literature available in electronic databases up to March 2018. The articles measuring EFT by echocardiography in the right ventricular (RV) free wall were included in the study. The quality of the enrolled items was assessed using the Methodological Index for Non-Randomized Studies (MINORS) checklist. The analyses were performed using the Comprehensive Meta-Analysis version 2 software. Cochran’s Q test and I2 index were used to evaluate heterogeneity.ResultsThis meta-analysis was performed on 13 studies involving 2,436 patients (1,622 with CAD, and 814 without CAD). The maximum EFT reported by echocardiography was 12.9±2.7 mm in the CAD group and 8.4±2.5 mm in the non-CAD group. The minimum EFT reported by echocardiography was 2.2±1.8 mm in the CAD group and 1.8±1.4 mm in the non-CAD group. The heterogeneity was found among the researched studies (I2=91.8%, p=0.000, Q-value=146.43, df [Q] =12) using the random effect model. The patients with CAD had a significantly higher echocardiographic EFT than those without CAD (SMD=1.03, 95% CI= 0.70–1.37, p=0.000).ConclusionAccording to the findings of this meta-analysis, the echocardiographic EFT in the subjects with CAD was significantly higher than that of those without CAD. The measurement of echocardiographic EFT seems to be an acceptable strategy for risk stratification of heart diseases considering ease of use, cost-effectiveness and non-exposure characteristics, compared to other imaging interventions.

show abstract

“…4 What is more, growth factors released from inflammatory cells (eg, monocytes) that attack the ischemic region in angiogenesis and arteriogenesis are also involved in this process. 1,3,13,14 Some cytokines initiate an inflammatory response by activating transcription factors. This stimulates the endothelium, resulting in a prompt release of presynthesized and stored molecules such as von Willebrand factor, P -selectin, CD63, interleukin 8, endothelin-1, tissue plasminogen activator, and Ang-2.…”

Section: Methods Study Design and Populationmentioning

confidence: 99%

“…2,3 Arteriogenesis INTRODUCTION Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. 1 In the clinical prognosis of CAD, the complexity and severity of atherosclerosis is as important as the resistance of the heart to ischemia. The myocardial tissue with a sufficiently rich collateral network is more resistant to ischemia.…”

mentioning

confidence: 99%

Relationship of serum calprotectin, angiopoietin‑1, and angiopoietin‑2 levels with coronary collateral circulation in patients with stable coronary artery disease

et al. 2019

View full text Add to dashboard Cite

BACKGROUND In patients with chronic stable coronary artery disease (CAD), well-developed coronary collateral circulation (CCC) is known to reduce long-term mortality. AIMS The objective of this study was to determine the relationship of serum calprotectin (S100A8 / S100A9), angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) concentrations with CCC in patients with stable CAD. METHODS This prospective cross-sectional study included 147 patients with stable angina pectoris. The Cohen-Rentrop classification was used to assess CCC. Patients were divided into 2 groups: with poor CCC (Cohen-Rentrop score, 0-1; n = 79) and with good CCC (Cohen-Rentrop score, 2-3; n = 68). Serum calprotectin, Ang-1, and Ang-2 concentrations were compated between groups. RESULTS Compared with the group with good CCC, serum calprotectin and Ang-1 levels were higher (P <0.01 and P <0.001, respectively), while serum Ang-2 levels were lower (P <0.01) in the poor-CCC group. C-reactive protein levels showed a moderate positive correlation with calprotectin levels (r = 0.359; P <0.001). In a multivariate regression analysis, only calprotectin (P <0.05) and Ang-1 (P <0.05) were found to be independent predictors of good and poor CCC. CONCLUSIONS Our study showed that Ang-2 levels were lower, while serum calprotectin and Ang-1 levels were higher, in patients with stable CAD and poor CCC regardless of the complexity and severity of coronary arteriosclerosis. If these results are confirmed in future studies, calprotectin may be considered a useful biomarker for guiding anti-ischemic treatment.

show abstract

Clinical usefulness of epicardial adipose tissue in patients with high-intermediate pre-test probability for coronary artery disease

Abstract: In patients with high-intermediate PTP, EAT is a useful measurement that may assist in risk stratification.

Cited by 5 publications

References 23 publications

Perivascular adipose tissue from the internal mammary artery in patients with severe coronary artery atherosclerosis

Perivascular adipose tissue from the internal mammary artery in patients with severe coronary artery atherosclerosis

Is echocardiographic epicardial fat thickness increased in patients with coronary artery disease? A systematic review and meta-analysis

Relationship of serum calprotectin, angiopoietin‑1, and angiopoietin‑2 levels with coronary collateral circulation in patients with stable coronary artery disease

Contact Info

Product

Resources

About