Objective
To evaluate the risk of cancer after assisted reproductive technology (ART)
therapy.
Design
Longitudinal cohort of New York, Texas, and Illinois residents between 2004-09,
treated with ART, and whose cycles were reported to the Society for Assisted
Reproductive Technology Clinic Outcomes Reporting System (SART CORS).
Setting
Not applicable
Patients
Cycles of 113,226 women, including 53,859 women without prior ART treatment,
were linked to their respective Cancer Registries. Standardized incidence ratios (SIR)
and their 95% confidence intervals were calculated, comparing the observed to expected
cancer cases based on age-specific cancer rates in the general population of each State.
Among the cohort of women without prior ART therapy, hazard ratios (HR) and 95%
confidence intervals were calculated for treatment parameters and reproductive history
factors.
Intervention
None
Main Outcome Measures
Diagnosis of cancer, as reported to the State Cancer Registry
Results
Mean follow-up was 4.87 years; among women without prior ART, 450 women
developed 460 cancers. Women treated with ART had significantly lower risks for all
cancers (for all women: SIR 0.78, 0.73-0.83; and women without prior ART: SIR 0.75,
0.68-0.82), breast cancer, and all female genital cancers; nonsignificant lower risks
for endocrine and uterine cancer; and nonsignificant higher risks for melanoma and
ovarian cancer. Among women without prior ART, there were no significant increased HRs
by parity, number of cycles, cumulative FSH dosage, or cycle outcome.
Conclusions
These results suggest no greater risks for developing cancer after nearly 5
years of follow-up compared to the general population, and to other women treated with
ART.
Capsule
These results suggest no greater short-term risks for developing cancer
compared to the general population, and to other women treated with ART.