Clinical use of Aglepristone for treatment of open-cervix pyometra in cats

Zhelavskyi, M. M.; Shunin, I.M.

doi:10.15421/nvlvet7802

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…In the present study, there was evidence of vaginal discharge post Alizin injection in female cats of groups A, B and C. The results of this study are in harmony with those reported earlier (Binli 2022), where vaginal discharge was observed in animals treated with Alizin injection; the vaginal discharge varied from yellowishgreen or greenish brown to brown in color. Similar observations were reported by Zhelavskyi and Shunin (2017) and Hagman (2018). Additionally, just like in the recent study (Binli 2022), vaginal discharge began to appear within 24hr post Alizin injection.…”

Section: Discussionsupporting

confidence: 88%

Pyometra in the Queen: Evaluation of Different Methods of Treatment

2023

Int J Vet Sci

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Pyometra is a common disease of female cats (queens) characterized by endometrial hyperplasia with cystic dilation of endometrial glands and accumulation of the neutrophil-rich exudate in the uterine lumen. In this study, 20 queens with the age range of 10 to 108 months (average 26 months) and diagnosed with pyometra (open and closed) between January 2019 and January 2021 were divided into four groups A, B, C and D, with five queens in each group. A first dose of Alizin® was given at 10mg/kg (S/C) to animals of groups A, B and C. In group A, the second dose of Alizin® was given 24hrs later while monitoring for vaginal discharge. In group B, upon notice of vaginal discharge at 24hrs, a dose of PGF 2α was given at 1.0mcg/kg BW (S/C) which eventually stopped the discharge. In group C, upon notice of vaginal discharge at 24hrs, a dose of Cytotec® was given intravaginally as 100mcg/cat. Group D was subjected to ovariohysterectomy and no complication was noted for 7 days post operation; on the 14th day, sutures were removed, and the surgical site healed completely. Vaginal discharge was noticed post Alizin® administration in groups A, B and C. Responses in three groups were observed 24 and 48hrs post treatment. In groups B and C, there was evidence of higher evacuated uterine pus compared to group A. Group C was better with no evidence of rapid respiration compared to groups B and A. There was evidence of general health response with the maximum resumption of feeding in groups B and C. In conclusion, the current study elucidated a different dimension for treating pyometra with an advantage of recovery and complete healing coupled with the response of maximum feeding for groups treated with Alizin in combination with PGF 2 or Misoprostol.

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Section: Discussionsupporting

confidence: 88%

Pyometra in the Queen: Evaluation of Different Methods of Treatment

2023

Int J Vet Sci

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“…Відомо багато способів усунення проявів статевої охоти, від радикальних -оваріоектомія, оваріогістеректомія, до менш радикальних гормональна контрацепція, яка при найменшому відхиленні від дози та похибки в застосуванні веде до розвитку небезпечних патологій статевої системи (піометра, полікістоз яєчників, пухлини молочної залози) та організму в цілому (ожиріння, цукровий діабет) (Sympson et al, 2005;Torrans and Muni, 2006;Yablonskij et al, 2008;Vasetska, 2016;Zhelavskyi and Shunin, 2017).…”

Section: вступunclassified

Method of comlex medicamental contraception in females of domestic animals

Васецька

Stefanyk

2018

SMLNUVMB

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The article presents studies on the use of hormonal contraceptive drugs based on megestrol acetate and comparisons with the developed by us comprehensive drug scheme of contraception. For the experiments were selected 115 clinically healthy female cats aged 1.5 to 6 years and 79 bitches aged 2 to 7 years. They were divided into two groups, control and experimental. Animals of the control group were given only the contraceptive drug on the basis of megestrol acetate, and the animals of the experimental group prescribed a contraceptive drug on the basis of megestrol acetate in combination with homoeopathic preparations «Ovaryovit» and «Mastometrin», which were injected intramuscularly in the dosage for middle and large dogs 2–4 ml, female cats and small breeds of dogs 0.5–2 ml, three times per week, course of treatment six weeks. Diagnosis of the reproductive system and the mammary gland of females of the control and experimental groups of animals for the presence of pathology were conducted one year after the administration of drugs by ultrasound and clinical examination. As a result of the research, it was found that as a result of the comprehensive use of the contraceptive drug on the basis of megestrol acetate with homoeopathic drugs «Ovaryovit» and «Mastometrin», the percentage of diseased animals in the experimental group (disorders at the reproductive system and mammary gland) among cats was less than 16% in comparison with control (P ≤ 0.005). The disorders at the reproductive system and mammary gland in the experimental group of cats were reversible and did not require surgical intervention. In the experimental group of bitches, the percent of animals with disorders in reproductive system and mammary gland were smaller by 22.4% compared with the control group of animals (P ≤ 0.005). And also all disorders at the reproductive system and mammary gland in the experimental group of cats were reversible and did not require surgical intervention. The use of drug contraception in combination with homeopathic remedies for the reproductive system of animals showed a significant reduction in the incidence of pathology of the reproductive system and the mammary gland in cats and females. The use of homeopathic remedies, simultaneously with the setting of synthetic progestogens, reduced the negative impact on the reproductive system and mammary gland of female animals (cats and bitches) with complete suppression of estrus.

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“…Его назначают кошкам с открытой формой пиометры подкожно в дозе 10 мг/кг массы тела на 1, 2, 7-е сут., ±14 сут. [22,30,42]. При хорошей клинической переносимости эффективность курса антигестагенной терапии составляет 90-100 % [22,30,42].…”

unclassified

“…[22,30,42]. При хорошей клинической переносимости эффективность курса антигестагенной терапии составляет 90-100 % [22,30,42].…”

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Incidence, risk factors, phathophisiology and modern aspects of therapy of feline pyometra

Dyulger¹,

Sibileva

Yakovleva³

et al. 2019

asj

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The article provides an overview of the frequency of distribution of pyometra in cats. Risk factors, clinical manifestations and clinical forms of the disease are analyzed. Current methods of pyometra diagnostics and clinical and laboratory criteria for early detection of signs of sepsis (systemic inflammatory response) in cats with pyometra are considered. The methods of pyometra therapy are analyzed. It was emphasized that the most effective and safest method of treating any form of pyometra is a total ovariohisterectomy in combination with broad-spectrum antibiotics. Encouraging results in the treatment of an open uncomplicated form of pyometers in cats were obtained using, along with antibiotics, preparations based on PgF2alfa and aglepristone.

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Clinical use of Aglepristone for treatment of open-cervix pyometra in cats

Cited by 3 publications

References 9 publications

Pyometra in the Queen: Evaluation of Different Methods of Treatment

Pyometra in the Queen: Evaluation of Different Methods of Treatment

Method of comlex medicamental contraception in females of domestic animals

Incidence, risk factors, phathophisiology and modern aspects of therapy of feline pyometra

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