Clinical Trials of Probiotic Strains in Selected Disease Entities

Dudek-Wicher, Ruth; Junka, Adam; Paleczny, Justyna; Bartoszewicz, Marzenna

doi:10.1155/2020/8854119

Cited by 36 publications

(27 citation statements)

References 46 publications

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“…However, the consistency and diversity of these gut microorganisms can be restored by taking a daily good-quality probiotic that will help keep the gut healthy [ 13 ]. Generally, recommended probiotic therapy/products may contain more than one selected microbial strain, mostly belonging to the following genera: Lactobacillus, Bifidobacterium and Lactococcus, Enterococcus and Streptococcus [ 14 ]. Moreover, strains of Gram-positive bacteria belonging to the genus Bacillus and some yeast strains belonging to the genus Saccharomyces are also used in probiotic products [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of diet on human gut microbiome and disease risk

Mansour

Moustafa

Saad

et al. 2021

New Microbes and New Infections

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The gut microbiome of humans comprises a diverse group of trillions of microorganisms including symbiotic organisms, opportunistic pathogens and commensal organisms. This microbiota plays a major role in digesting food; it also helps with absorbing and synthesizing some nutrients and releases their metabolites, which may deliver a variety of growth-promoting and growth-inhibiting factors that influence human health either directly or indirectly. The balance between microbial species, especially those responsible for the fermentation of different substrates within the microbial community, which are in the majority, depends on daily diet. Therefore, an unbalanced diet may lead to the progression and development of human diseases. These include metabolic and inflammatory disorders, cancer and depression, as well as infant health and longevity. We provide an overview of the effect of diet on the human microbiome and assess the related risk of disease development.

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Section: Introductionmentioning

confidence: 99%

Impact of diet on human gut microbiome and disease risk

Mansour

Moustafa

Saad

et al. 2021

New Microbes and New Infections

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show abstract

“…The long history of safe production of fermented food, such as Emmental cheese, and the bacterium status of "generally recognized as safe" (GRAS) and "qualified presumption of safety" (QPS) assure the safety of P. freudenreichii consumption [5,93]. However, additional assessments need to be conducted in different matrices and contexts.…”

Section: Safety Assessmentsmentioning

confidence: 99%

Propionibacterium freudenreichii: General Characteristics and Probiotic Traits

Rodovalho¹,

Rodrigues²,

Jan³

et al. 2022

Prebiotics and Probiotics - From Food to Health

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Propionibacterium freudenreichii is a Gram-positive dairy probiotic bacterial species that has been used as a ripening starter in the production of Swiss-type cheese for a long time. It has been exploited for the optimization of cheese production, including ripening capacities and aroma compounds production, but also for the production of vitamin B12 and organic acids. Furthermore, it has emerged in the probiotics landscape owing to several beneficial traits, including tolerance to stress in the gastrointestinal tract, adhesion to host cells, anti-pathogenic activity, anticancer potential and immunomodulatory properties. These beneficial properties have been confirmed with in vitro and in vivo investigations, using several omics approaches that allowed the identification of important molecular actors, such as surface proteins, short-chain fatty acids and bifidogenic factors. The diversity within the species was shown to be an important aspect to take into consideration, since many of these properties were strain-dependent. New studies should dive further into the molecular mechanisms related to the beneficial properties of this species and of its products, while considering the complexities of strain diversity and the interactions with the host and its microbiota. This chapter reviews current knowledge on the possible impact of P. freudenreichii on human health.

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“…These days, probiotics are widely using in various pathways for addressing many medical problems [ 21 ]. For instance, the emergence of several infectious agents, which are multi-drug-resistant (MDR), has led to public health concerns.…”

Section: Main Textmentioning

confidence: 99%

Evaluation of E. coli Nissle1917 derived metabolites in modulating key mediator genes of the TLR signaling pathway

Damoogh¹,

Vosough²,

Hadifar³

et al. 2021

BMC Res Notes

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Objective Gut-microbiota plays key roles in many aspects like the health and illness of humans. It's well proved that modification of gut microbiota by probiotics is useful for improving inflammatory bowel disease (IBD) conditions. According to recent studies, different types of bacterial metabolites can affect immune cells and inflammation conditions. The present study aimed to evaluate the anti-inflammatory effects of metabolites of E. coli Nissle1917. Results The cell-free supernatant could modulate TNF-α production and affected many crucial mediators in the Toll-like receptor (TLR) signaling pathway. Also, supernatant showed significant dose-dependent properties in this regard. In this study, the TLR signaling pathway was found among probable mechanisms by which probiotics can affect inflammatory situations. These findings provide additional evidence on the use of probiotic metabolites for inhibiting and down-regulating numerous key mediator factors in the TLR signaling pathway. Aberrant or dysfunctional TLR signaling contributes to the development of acute and chronic intestinal inflammatory pathways in IBD. Therefore, finding a component that can affect this process might be considered for therapeutic targets in IBD patients.

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Clinical Trials of Probiotic Strains in Selected Disease Entities

Cited by 36 publications

References 46 publications

Impact of diet on human gut microbiome and disease risk

Impact of diet on human gut microbiome and disease risk

Propionibacterium freudenreichii: General Characteristics and Probiotic Traits

Evaluation of E. coli Nissle1917 derived metabolites in modulating key mediator genes of the TLR signaling pathway

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