Clinical Trials for Cardiac Pacing in Bradycardia

Tse, Hung‐Fat; Lau, Chu‐Pak

doi:10.1161/circulationaha.106.635854

Cited by 10 publications

(3 citation statements)

References 23 publications

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“…2 However, considerable differences have been reported in the frequency of implantation of pacemakers and in the system selected. 3,4 Gender differences are increasingly recognized in medicine and especially in cardiology. From previous studies, it is known, for example, that women have a higher likelihood for complications and a higher mortality related to coronary revascularization procedures.…”

Section: Introductionmentioning

confidence: 99%

Gender Differences in Selection of Permanent Pacemaker Implantation at Manmohan Cardiothoracic Vascular and Transplant Centre, Kathmandu, Nepal

Khanal¹,

Poudyal²,

Devkota³

et al. 2015

J Nobel Med Coll

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Background: Permanent pacemaker implantation is a minimally invasive surgical procedure in the management of patients with cardiac rhythm disturbances. Previous studies have reported gender differences in pacemaker selection. There is lack of evidences in selection of pacemaker mode with respect to gender in Nepal. Therefore, this study was performed to compare the frequency of implantation between men and women.Objectives: This study was performed to compare the frequency of implantation rate between men and women. Methods:The present study is based on all consecutive pacemaker implantations in a single centre between April 2014 and May 2015. A total of 116 patients were categorized into two cohorts according to the type of pacemaker implanted-single chamber or dual chamber. Data were presented as means ± standard deviation (SD) for continuous variables and as proportions for categorical variables. Comparison of continuous variables between the groups was made with independent Student's t-test. For discrete variables distribution between groups were compared with Chi-square test. Results:The mean age (±SD) of total population at implant was 64.08 (± 15.09) years. Dual chamber units were implanted in 44 (37.93%) of patients, single chamber in 72 (62.06%). Only 14 women (31.81%) received dual chamber compared with 42 women (58.33%) who received single chamber (Chi-square=18, DF=1, P = 0.0084). Complete atrioventricular block was the commonest (56.03%) indication for permanent pacemaker insertion followed by sick sinus syndrome (33.62%), symptomatic high-grade AV block (11.20%). Hypertension (dual chamber 21.55%, single chamber 40.51%) was the most common comorbidity in both cohorts. Conclusions:Women were more likely to receive single chamber systems and less likely to receive dual chamber systems than men.

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Section: Introductionmentioning

confidence: 99%

Gender Differences in Selection of Permanent Pacemaker Implantation at Manmohan Cardiothoracic Vascular and Transplant Centre, Kathmandu, Nepal

Khanal¹,

Poudyal²,

Devkota³

et al. 2015

J Nobel Med Coll

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show abstract

“…This concept, as originally proposed, referred to pacing techniques that were designed to allow for normal cardiovascular physiology, preserve atrioventricular (AV) synchrony, and provide heart rate increases (rate adaptiveness) as required by exercise or other physiological demands. 16 Although this improved symptoms in many patients and reduced the incidence of atrial fibrillation (AF) compared with singlechamber pacing, no benefit was identified in certain patient subsets, [17][18][19] as in the PASE (Pacemaker Selection in the Elderly) 17 and UKPACE (United Kingdom Pacing and Cardiovascular Events) 18 trials. Furthermore, potential adverse consequences of right ventricular apical pacing have led to the evaluation of alternative sites for pacing the heart, 20 and our definition of physiological pacing continues to evolve.…”

Section: Changing Indications For Device Therapymentioning

confidence: 99%

Contemporary Pacemaker and Defibrillator Device Therapy

Schoenfeld

2007

Circulation

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“…More importantly, the presence of AF episodes after pacemaker implantation is associated with an increased risk of major cardiovascular events, including stroke, hospitalization for congestive heart failure, and cardiovascular death 3,4 . Prospective randomized clinical trials show that atrial‐based pacing in patients with SND reduced the risk of AF compared with ventricular‐based pacing, 5,6 especially when the percentage of ventricular pacing can be minimized 7 …”

Section: Introductionmentioning

confidence: 99%