Clinical Trial of Povidone-Iodine (Betadine) versus Placebo in the Pretreatment of Corneal Ulcers

Gregori, Ninel Z.; Schiffman, Joyce C.; Miller, Darlene; Alfonso, Eduardo C.

doi:10.1097/01.ico.0000214220.67872.b1

Cited by 12 publications

(5 citation statements)

References 15 publications

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“…In agreement with the present study Gregori et al compared the effect of 5 % povidone iodine with placebo drops (one drop of each,10 minutes before antibiotic treatment) in the treatment of corneal ulcer, and they concluded that the effect povidone iodine has no effect in reducing the number of bacteria on the cornea (13). In agreement with the present study Melki et al compared the effect of 0.5 % and 10 % povidone iodine with ofloxacin 0.3 % on 21 rabbit eyes for a period of eight hours, and revealed that although 0.5 % povi-done iodine has a greater bactericidal effect compare to the untreated cases, but however, its effect is less than ofloxacin (14).…”

Section: Discussionsupporting

confidence: 91%

Comparison of Vancomycin and Cefazolin Therapeutic Effect with Povidone Iodine on Corneal Ulcer in Rabbits

Feghhi¹,

Amin

Zamani

et al. 2012

Jundishapur J Microbiol

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Lower effect of povidone iodine may be the result of the lack of deep penetration of this drug into the corneal stroma, but other factors may be involved. Background: Corneal ulcer is a common cause of blindness in developing countries, as itleads to corneal perforation and blindness if not properly treated. Objectives: This study aimed to determine the effects of intraocular 5 % and 10 % topical povidone iodine in the treatment of bacterial corneal ulcer in a rabbit model, comparing the effectiveness of vancomycin and cefazolin eye drops. Materials and Methods: Total of 40 eyes ofrom 20 wild rabbits were randomly assigned to four equal groups, five in each (n = 5), they included; group 1. 5 % povidone iodine and vancomycin; group 2.5 % povidone iodine and cefazolin; group 3.10 % povidone iodine and vancomycin; group 4.10 % povidone iodine and cefazolin (one drop every two hours for seven days and nights). The animals were first anesthetized with ketamine hydrochloride and xylazine chloride. Then, a 27-gauge needle attached to a 1-ml syringe was tunneled through the clear cornea to approximately midstromal depth, stopping at the edge of the 2-mm optical zone. Finally, 0.02 ml of Staphylococcus contaminated media containing about 100 organisms was injected, forming a central intra-stromal infiltrate. Results: There was no statistically significant difference in the density of infiltration, size of infiltration, hypopyon, or fibrin formation between the four groups. However, epithelial defect, stromal edema, conjunctival injection, and chemosis were significantly higher in the 5 % and 10 % povidone iodine groups when compared to the cefazolin and vancomycin groups. Thinning was more common in the cefazolin group. There was one sealed corneal perforation in the cefazolin group at the beginning, and at day 6, one perforation in the cefazolin group and one perforation in the 10 % povidone iodine group also developed. Conclusions: Cefazolin and vancomycin had a superior clinical effect on the staphylococcal corneal ulcers in this study. 5 % and 10 % povidone iodine was toxic to the corneal epithelium. Thinning and perforation was more common with cefazolin.

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Section: Discussionsupporting

confidence: 91%

Comparison of Vancomycin and Cefazolin Therapeutic Effect with Povidone Iodine on Corneal Ulcer in Rabbits

Feghhi¹,

Amin

Zamani

et al. 2012

Jundishapur J Microbiol

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“…One drop of 5% povidone-iodine for 2 min has been shown to reduce the culture-positive swabs from 75% prior to instillation to 28% after 33. However, a randomised controlled trial assessing a single 10 min povidone-iodine instillation before corneal scrape in patients presenting with bacterial keratitis did not reveal a statistically significant difference between the pre- and postinstillation load of pathogen 34. In the povidone-iodine form, the majority of iodine is in the non-toxic stable tri-iodide form 35.…”

Section: Discussionmentioning

confidence: 97%

Management of blebitis in the United Kingdom: a survey: Table 1

et al. 2011

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“…Although there are no obvious toxic effects of PI irrigation on the ocular surface before intraocular surgery, uncomfortable symptoms including irritation, itching and burning have been reported 18 19. PI irrigation has been used to kill exfoliated viable tumour cells during colorectal cancer surgery to reduce anastomotic recurrence 20.…”

Section: Discussionmentioning

confidence: 99%

Povidone-iodine application induces corneal cell death through fixation

Chou

Lin

Chang

2010

British Journal of Ophthalmology

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Clinical Trial of Povidone-Iodine (Betadine) versus Placebo in the Pretreatment of Corneal Ulcers

Abstract: A single application of 5% Betadine did not reduce the bacterial load of corneal ulcers more than just scraping/rinsing alone. This is likely the result of the lack of penetration deep into the corneal stroma and number of organisms present. Other factors may be involved.

Cited by 12 publications

References 15 publications

Comparison of Vancomycin and Cefazolin Therapeutic Effect with Povidone Iodine on Corneal Ulcer in Rabbits

Comparison of Vancomycin and Cefazolin Therapeutic Effect with Povidone Iodine on Corneal Ulcer in Rabbits

Management of blebitis in the United Kingdom: a survey: Table 1

Povidone-iodine application induces corneal cell death through fixation

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