Clinical trial/experimental study (consort compliant): Optimal time period to achieve the effects on synbiotic-controlled wheezing and respiratory infections in young children

Abstract

The optimal duration of administration of the synbiotic containing three probiotic cultures to provide effective control of the frequency of respiratory infections was three months, and six months were required to establish control of the frequency of wheezing. This synbiotic is useful for immunomodulation in children and is well-tolerated in young children.

The “Obese Asthma” in Children as a Distinct Clinical Phenotype: Review

“…We have, also, confirmed that the use of synbiotics in the optimal period of time of 3-6 months can achieve adequate control of respiratory infection and allergic wheezing diseases in children younger than 5 years [34]. Nevertheless, we have found that the time necessary for the restitution of the immune balance between immunoglobulin A and immunoglobulin E was 9 months in the youngest children [34]. Now, we can add a logical setting as hypothesis that should have been assessed in clinical trials, that the everyday application of synbiotic (during several months) after antibiotic using would likely prevent the obesity.…”

“…It has been proven that "good" probiotic bacteria and "good" probiotic fungi in the mouth and intestines, sufficiently represented, are necessary to compensate destroyed intestinal flora during and after antibiotic therapy and for the health of children [5] ( Figure 1). We have, also, confirmed that the use of synbiotics in the optimal period of time of 3-6 months can achieve adequate control of respiratory infection and allergic wheezing diseases in children younger than 5 years [34]. Nevertheless, we have found that the time necessary for the restitution of the immune balance between immunoglobulin A and immunoglobulin E was 9 months in the youngest children [34].…”

“…The duration of substitution with probiotics or synbiotics during and after discontinuation of macrolides should be determined in future studies. From our current perspective and findings, and bearing in mind the long-term disruption (24 months) of the intestinal microbiota, we suggest a period of, at least, 9 months of probiotics or synbiotics supplementation, which is necessary time for the restitution of immune balance between immunoglobulin A and E, in the youngest children [34,44]. We join the recommendation, to avoid all antibiotics, in particular macrolides, for the "irresponsible" treatment of viral infections in the youngest children, or several times a year, or longer than the prescribed time and doses for macrolides [45] and penicillin [46].…”

Influence of Lactobacillus Spp. On Colonization and Anti-Infectious Resistance of the Mucous Membranes of the Upper Respiratory Tract

“…According to the literature, application of probiotics or synbiotic treatment regimens in respiratory infections reduces relapse respiratory tract infections and bronchial obstruction in children [9]. But the authors did not conduct any studies to determine the number of lactobacilli in secrets of URt and their influence on anti-infectious resistance of mucous membranes.…”

“…Probiotics based on lactobacilli are widely used to prevent and treat dysbiotic conditions of digestive and genital human system [6][7][8]. Nowadays, research on the use of lactobacilli for prevention or treatment of infections and recovery of anti-infectious resistance of mucous membranes of upper respiratory tract (URT) are actual [9].…”