Clinical trait-connected network analysis reveals transcriptional markers of active psoriasis treatment with Liangxue-Jiedu decoction

Li, Yajun; Zhou, Tao; Zhang, Jing; Zhang, Lei; Ke, Hai; Zhang, Cang; Li, Ping

doi:10.1016/j.jep.2020.113551

Cited by 15 publications

(8 citation statements)

References 45 publications

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“… 26 Additionally, Li and colleagues demonstrated that CCNB2 expression was decreased in patients with psoriasis who showed alleviation of symptoms. 27 These findings are similar to our results in the recurrence of psoriasis. In contrast to the results of our reports, the expression of most hub genes associated with the cell cycle and proliferation in scalp psoriatic samples, revealed no significant differences from that of paired control samples.…”

Section: Discussionsupporting

confidence: 92%

Bioinformatic Analysis and Translational Validation of Psoriasis Candidate Genes for Precision Medicine

Li¹,

Li²,

Yu³

et al. 2022

CCID

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Background: Psoriasis is a recurrent, chronic, inflammation-and immune-mediated skin disease with multiple causative factors. However, the genetic markers associated with recurrence have not yet been fully elucidated. Accordingly, in this study, we aimed to identify markers associated with the recurrence of psoriasis. Methods: We analyzed differentially expressed genes to determine which targets were associated with the recurrence of psoriasis and used these data to construct a protein-protein interaction network using Cytoscape software. The results were then validated by analysis of core targets using Gene Expression Omnibus (GEO) datasets and clinical samples. Functional enrichment analysis was used to explore the potential mechanisms mediating the recurrence of psoriasis. Results: We screened out six core targets that played important roles in recurrence of psoriasis, and validation of GEO datasets and clinical samples showed that the expression levels of five core targets were higher in patients with psoriasis than in healthy individuals. Functional enrichment analysis revealed that the cell cycle and oocyte meiosis signaling pathways were involved in the recurrence of psoriasis. Conclusion: Our findings provided insights into the mechanisms mediating the onset and recurrence of psoriasis.

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Section: Discussionsupporting

confidence: 92%

Bioinformatic Analysis and Translational Validation of Psoriasis Candidate Genes for Precision Medicine

Li¹,

Li²,

Yu³

et al. 2022

CCID

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“…TCM, which is a system of ancient medical practice that differs from contemporary medicine in its substance, methodology, and philosophy, plays an essential part in the health maintenance of Asian peoples, and it is becoming more frequently adopted in countries around the Western world [ 16 ]. Despite their growing popularity, there are still some misconceptions about traditional medicines and the standards they must satisfy to be effective.…”

Section: Types Of Psoriasismentioning

confidence: 99%

TCM Treatment and Drug Co-Occurrence Analysis of Psoriasis

Yang

Bai

et al. 2022

Computational Intelligence and Neuroscience

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Psoriasis is a long-term immune-mediated disease. Patients with a long history and slow progress are more common, and its treatment is difficult. This study proposes to use traditional Chinese medicine to treat psoriasis. Through the follow-up of all participants for 12 and 24 weeks, a large number of comparative experiments effectively verify the effectiveness of the method proposed in this study. The research results of this study can provide some reference ideas for follow-up research.

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“…The Role of the BTLA/CD160:HVEM Pathway in Psoriasis Recent study showed that the gene expression of CD160 and BTLA was significantly lower in psoriasis patients with health control (Youssef et al, 2019;Li et al, 2021). Another study reported that CD160 acts as a co-activator receptor for CD3induced proliferation of CD4 + CD160 + T cells isolated from psoriatic lesions (Abecassis et al, 2007).…”

Section: Co-inhibitory Moleculesmentioning

confidence: 99%

The Role of Co-Signaling Molecules in Psoriasis and Their Implications for Targeted Treatment

Liu

Xu²,

Wu³

2021

Front. Pharmacol.

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Psoriasis is a chronic, systemic immune-mediated inflammatory disease manifesting in the skin, joint or both. Co-signaling molecules are essential for determining the magnitude of the T cell response to the antigen. According to the function of co-signaling molecules, they can be divided into co-stimulatory molecules and co-inhibitory molecules. The role of co-signaling molecules in psoriasis is recognized, mainly including the co-stimulatory molecules CD28, CD40, OX40, CD27, DR3, LFA-1, and LFA-3 and the co-inhibitory molecules CTLA-4, PD-1, and TIM-3. They impact the pathological process of psoriasis by modulating the immune strength of T cells, regulating the production of cytokines or the differentiation of Tregs. In recent years, immunotherapies targeting co-signaling molecules have made significant progress and shown broad application prospects in psoriasis. This review aims to outline the possible role of co-signaling molecules in the pathogenesis of psoriasis and their potential application for the treatment of psoriasis.

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Clinical trait-connected network analysis reveals transcriptional markers of active psoriasis treatment with Liangxue-Jiedu decoction

Cited by 15 publications

References 45 publications

Bioinformatic Analysis and Translational Validation of Psoriasis Candidate Genes for Precision Medicine

Bioinformatic Analysis and Translational Validation of Psoriasis Candidate Genes for Precision Medicine

TCM Treatment and Drug Co-Occurrence Analysis of Psoriasis

The Role of Co-Signaling Molecules in Psoriasis and Their Implications for Targeted Treatment

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