TCM Treatment and Drug Co-Occurrence Analysis of Psoriasis

Li, Lin; Yang, Suqing; Bai, Qingsong; An, Yuepeng

doi:10.1155/2022/4268681

Cited by 3 publications

(4 citation statements)

References 23 publications

(21 reference statements)

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“…According to traditional Chinese medicine, psoriasis is mainly divided into three types of syndromes (blood heat, blood stasis and blood dryness), so psoriasis is mainly treated from the blood [43]. And herbs with the effect of dispersing blood stasis or cooling blood such as Curcuma Aeruginosa Roxb, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Indigo Naturalis, Rubix Rubiae etc are frequently appeared at the prescriptions as the main herb when treating psoriasis [44][45][46]. PSORI is a cipher prescription our hospital used to treat psoriasis for many years [44,48], it contained two kinds of drugs, one is herbs with dispersing blood stasis effect and the other is with the effect of clearing heat-toxin, when compared their effect on psoriasis in mice model, the results showed that dispersing blood stasis drugs showed a better effect [49], and this is accorded with the theory of traditional Chinese Medince and the results of manuscript.…”

Section: Discussionmentioning

confidence: 99%

Increased abnormal erythrocytes caused by spleen filtration deficiency provide a hypoxic environment for the occurrence of psoriasis

Zhao

Fan

et al. 2022

Preprint

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Background Psoriasis is a chronic autoimmune disease with a long disease course and frequent relapse characteristics, however, its pathogenesis is still not completely clear. Clinical study indicated that blood state is abnormal in psoriasis and seems related with the severity of psoriasis. However, whether this is true and which constituents of blood play the key role and its mechanism behind is not clear. Methods Effect of blood constituents on the psoriasis development was determined by comparing serum, red cells, and leukocytes of psoriasis on the onset of psoriasis of NOG mice, using samples of healthy people as the control. The effect of red cell on psoriasis was further demonstrated by splenectomy using Kunming mice. Red cell morphology and spleen histopathology were studied by microscope. IL-6, IL-17A, IL-23, VEGF, IL-22, MDA, NO and HIF were determined by Elisa kits, and q-PCR was used to detect the mRNA of IL-6, IL-22, and IL-23, and western blot was used to detect CD-11b, SPIC, SIPR-α, TSP-1, and CD47. Results The hemorheology of psoriatic patients to be abnormal, and aging and deformed erythrocytes increased in the blood. Red cell and leukocyte from psoriasis were more likely to induce psoriasis when comparing with that of from the healthy volunteers, and the effect of red cell was more strong. When splenectomy, mice were also easy to induce psoriasis, demonstrating by the skin lesion, inflammatory factors and histopathology which all similar with psoriasis patients. Psoriasis spleen showed an increased red pulp and white pulp, and increased CD-11b, SPIC, TSP-1 and decreased SPRP-α, CD47 showed marginal change, indicated that the weakening of the “eat me” function of spleen macrophages phagocytizing aging and deformed erythrocytes, resulting in the dysfunction of spleen filtration and the increase of aging and deformed erythrocytes in the body. Additionally, the decreased oxygen-carrying capacity and the declined antioxidant capacity of those erythrocytes led to the hypoxia environment, making psoriasis more likely to be induced. Conclusion These findings demonstrate that spleen filtration dysfunction contributes to the pathogenesis of psoriasis and suggest that improving it may be an effective therapy for psoriasis and control its relapse.

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Section: Discussionmentioning

confidence: 99%

Increased abnormal erythrocytes caused by spleen filtration deficiency provide a hypoxic environment for the occurrence of psoriasis

Zhao

Fan

et al. 2022

Preprint

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“…It focuses on a holistic view that combines evidence differentiation with treatment methods, appropriate coordination of the 3 methods, flexible treatment methods, low side effects, and low recurrence rates after clinical cure. [9,10] Fire needle therapy has the characteristics of simplicity, convenience, testing, and integrity and is an important part of the traditional characteristic therapy of TCM. [11] In ancient times, it was also called "thorn" and "burnt needle," which specifically refers to the tip of the needle after burning red and quickly stabbed into the acupoint.…”

Section: The Authors Have No Conflicts Of Interest To Disclosementioning

confidence: 99%

Effect of fire needle combined with traditional Chinese medicine on psoriasis: A systematic review and meta-analysis

Xu,

Zhou,

Xie

et al. 2024

Medicine

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Background: The mechanism of action of fire acupuncture and Chinese medicine in psoriasis is unclear. In this paper, the efficacy of the 2 therapies was compared through a comprehensive analysis of their recurrence rates for clinical reference. Methods: In this meta-analysis, we searched PubMed, Embase, Cochrane Library, CNKI, Wanfang, CQVIP, and CBM data from the establishment of the databases to May 2023. The study proposed to use randomized controlled trial research methods, excluding published literature, unpublished literature, literature with incomplete or inadequate information, animal experiments, literature reviews and systematic studies. Data were processed using STATA 15.1 software. Results: Our group previous study found that the clinical efficacy of the fire-acupuncture group was significantly improved compared to that of Chinese herbal medicine alone (RR = 1.20, 95% CI: 1.13–1.27). Also, there were significant reductions in Psoriasis Area and Severity Index (PASI) score (SMD = −1.04,95% CI: −1.48 to −0.60), area of skin damage (SMD = −0.40,95% CI: −0.75 to −0.04), and pruritus (SMD = −1.04,95% CI: −1.32 to −0.76). Our previous study found that Dermatology Life Quality Index (DLQI) was significantly lower in the fire acupuncture group compared to herbal medicine alone (SMD = −1.61,95% CI: −3.08 to −0.15). The combined analysis found that the recurrence rate was significantly lower in the fire-acupuncture group compared to herbal medicine alone (RR = 0.21,95% CI:0.07–0.60). Conclusion: Fire needle can improve the efficacy of TCM in the treatment of psoriasis, including the area, severity and itching of skin lesions, and reduce the recurrence rate, which is worthy of clinical promotion.

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“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

mentioning

confidence: 99%

“…Tis article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. Tis investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”

mentioning

confidence: 99%

Retracted: TCM Treatment and Drug Co‐Occurrence Analysis of Psoriasis

Neuroscience¹

2023

Computational Intelligence and Neuroscience

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TCM Treatment and Drug Co-Occurrence Analysis of Psoriasis

Cited by 3 publications

References 23 publications

Increased abnormal erythrocytes caused by spleen filtration deficiency provide a hypoxic environment for the occurrence of psoriasis

Increased abnormal erythrocytes caused by spleen filtration deficiency provide a hypoxic environment for the occurrence of psoriasis

Effect of fire needle combined with traditional Chinese medicine on psoriasis: A systematic review and meta-analysis

Retracted: TCM Treatment and Drug Co‐Occurrence Analysis of Psoriasis

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