Clinical, Toxicological, and Pathological Aspects of Arsanilic Acid Poisoning in Swine

Ledet, A. E.; Duncan, James Robert; Buck, William B.; Ramsey, Fred L.

doi:10.3109/15563657308990543

Cited by 16 publications

(11 citation statements)

References 16 publications

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“…The As concentration in the muscle was under detection limit (<10 ppb) of the updated detection method current available for analytical laboratories. Similar As distribution pattern was observed by Ledet et al (1973), who reported that the concentrations of As in the liver and kidney were much higher than in the muscle of the pigs consumed high As diets [ 25 , 37 ]. Ledet et al (1973) reported that the As concentrations in liver and kidney were close (9.67 and 8.33 ppm, respectively) in the pigs fed with 1000 ppm As-containing diet.…”

Section: Discussionsupporting

confidence: 81%

Feeding Arsenic-Containing Rice Bran to Growing Pigs: Growth Performance, Arsenic Tissue Distribution, and Arsenic Excretion

Liao

Hasan

Yang

et al. 2020

IJERPH

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This research was conducted to study the growth performance, arsenic (As) tissue distribution, and As excretion of pigs fed As-containing rice bran. Twenty gilts (26.3 kg) were randomly assigned to 3 dietary treatments (n = 6 or 7) with Diets I, II, and III containing 0, 36.7, and 73.5% rice bran and 0, 306, and 612 ppb As, respectively. Pigs were fed for 6 weeks, and their growth performance and daily activities were examined. Fecal, blood, and hair samples were collected immediately before and after the 6-weeks. At the end of the 6-weeks, pigs were slaughtered; the liver, kidney, muscle, and urine samples were collected. No pig showed any unhealthy signs throughout the trial. The average daily feed intake, average daily gain, and final body weight of Diet III pigs were lower (p ≤ 0.001) than Diet I pigs. The gain to feed ratios were not different among the treatments. The fecal, hair, kidney, and urinary As concentrations of both Diets II and III pigs were higher than Diet I pigs. The hair As concentration of Diet III pigs was higher than Diet II pigs, but no difference was found in the fecal, urinary, kidney, or muscle As concentrations between Diets II and III pigs. The blood and muscle As concentrations were below 10 ppb. These results suggest that 73.5% dietary rice bran inclusion compromised growth performance, whereas the 36.7% inclusion did not. The fecal As data imply that dietary As was poorly absorbed by the gastrointestinal tract. The tissue As data indicate that the absorbed As was rapidly cleared from the blood with some retained in various organs and others eliminated via urine. The hair As concentration was much higher than that of liver and kidney. The muscle As data suggest that the pork produced from the pigs fed a typical As-containing rice bran as used in this study is safe for human consumption.

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Section: Discussionsupporting

confidence: 81%

Feeding Arsenic-Containing Rice Bran to Growing Pigs: Growth Performance, Arsenic Tissue Distribution, and Arsenic Excretion

Liao

Hasan

Yang

et al. 2020

IJERPH

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“…In these animals the mortality rate is low, and no changes have been noted in samples from tissues at autopsy except for peripheral nerves 8. However, data from animal experiments with PAA have shown less effective clearance of this substance from the central nervous system than in peripheral organs 8. Magnetic resonance imaging in Case 2 showed brain atrophy, suggesting that DPAA intoxication can result in a pathological change in the central nervous system.…”

Section: Discussionmentioning

confidence: 90%

“…Previous reports have described staggering, incoordination, ataxia, and quadriplegia in some domestic animals exposed to these chemical additives. In these animals the mortality rate is low, and no changes have been noted in samples from tissues at autopsy except for peripheral nerves 8. However, data from animal experiments with PAA have shown less effective clearance of this substance from the central nervous system than in peripheral organs 8.…”

Section: Discussionmentioning

confidence: 90%

Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan

Ishii

Tamaoka

Otsuka

et al. 2004

Annals of Neurology

116

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We noted a new clinical syndrome with prominent cerebellar symptoms in apartment building residents in Kamisu, Japan. The well that provided drinking water contained diphenylarsinic acid, a degradation product of diphenylcyanoarsine or diphenylchloroarsine, which were developed for use as chemical weapons, inducing severe vomiting and sneezing. Characteristics of diphenylarsinic acid poisoning include brainstem-cerebellar and cerebral symptoms. Mental retardation associated with brain atrophy in magnetic resonance images was evident in some infants. We must be vigilant to prevent or minimize the effects of further diphenylarsinic acid poisoning in Japan or elsewhere.

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“…Increasing levels to 1000 ppm arsanilic acid in the diet of swine produced posterior paresis or quadriplegia in 15 days (Ledet et al 1973). Levels of 7.5 to 7.8 and 6.8 to 12.3 ppm (wet weight)…”

Section: Vyl41dulmentioning

confidence: 99%

“…Toxicosis by phenylarsonic compounds apparently involves peripheral nerve degeneration and symptoms include incoordination, inability to control body and limb movements, and ataxia. The condition may progress to quadriplegia (Ledet et al . 1973) 0141754…”

Section: Arsenic Poisoning In Livestock By Inhalationmentioning

confidence: 99%

Assessment of the toxicity of arsenic, cadmium, lead and zinc in soil, plants, and livestock in the Helena Valley for East Helena site (ASARCO), East Helena, Montana

1987

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Extractable soil cadmium 3.3.3 Cadmium in plants 3.3 Lead in soils and plants 3.3.1 Lead literature review 3.3.2 Lead in soils 3.3.2.1 Total lead in soils 3.3.2.2 Extractable soil lead 3.3.3 Lead in plants 3.4 Zinc in soils and plants 3.4.1 Zinc literature review 3.4.2 Zinc in soils 3.4.2.1 Total zinc in soils 3.4.2.2 Extractable soil zinc 3.4.3 Zinc in plants 4.0 Hazard Levels for Water 4.1 Water Quality Levels for Livestock 4.2 Water Quality Levels for Irrigation 136 5.0 Regulatory Criteria From Other Technologies 138 5.1 Criteria from Land Application of Sewage Sludge 138 5.2 Criteria from Coal Overburden Suitability for Root Zone Material 143 5.3 Criteria for Defining Hazardous Wastes 143 5.4

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Clinical, Toxicological, and Pathological Aspects of Arsanilic Acid Poisoning in Swine

Cited by 16 publications

References 16 publications

Feeding Arsenic-Containing Rice Bran to Growing Pigs: Growth Performance, Arsenic Tissue Distribution, and Arsenic Excretion

Feeding Arsenic-Containing Rice Bran to Growing Pigs: Growth Performance, Arsenic Tissue Distribution, and Arsenic Excretion

Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan

Assessment of the toxicity of arsenic, cadmium, lead and zinc in soil, plants, and livestock in the Helena Valley for East Helena site (ASARCO), East Helena, Montana

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