The effectiveness of nanogold-nanosilver hand soap on hand skin using the statistical test method "paired sample T-test" by the application of SPSS gets a Sig. 2 - tailed value = 0. Based on theory, if the value is less than 0,05 it indicates that there is a significant difference in the effectiveness of using nanogold-nanosilver hand soap which is better than using hand soap in general. The organoleptic test of the color, scent, and texture indicators of the two soaps (between standard hand soap and nanogold-nanosilver hand soap) are on average liked by respondents, and also showed an increase of 24% the condition of the hand skin became more moist and by 19% the skin of the hands became smoother. The ratio of the mixture of nanogold-nanosilver hand soap is 7: 2: 1. Ratio 7 is hand soap in general, ratio 2 is nanosilver 20 ppm, and ratio 1 is nanogold 20 ppm, this is based on the results of the most stable concentration characteristics test at a concentration is 20 ppm with an average nanoparticle size is 21,205 nm and known to have 9 clusters. The results of the nanogold antioxidant activity test resulted in an IC50 value of 13,4691 ppm.