Clinical Tears in the Retina without Detachment*

Colyear, Bayard H.; Pischel, Dohrmann K.

doi:10.1016/0002-9394(56)91770-6

Cited by 52 publications

(8 citation statements)

References 13 publications

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“…7 Further evidence for an adverse effect on retinal adhesion is that all eight of the BEAVRS cases with a retinal tear went on to develop a retinal detachment, whereas natural history studies of spontaneous posterior vitreous detachment suggest that only 30-50% of tears progress to retinal detachment. [10][11][12] The 46.9% incidence of widening of the FTMH basal diameter in failed ocriplasmin cases could have implications for visual outcomes, as increased basal diameter has previously been found to predict worse post-operative vision; 13 however, this was not found in the MIVI TRUST trials where the acuity improvement in failed ocriplasmin eyes was the same as in placebo treated eyes. 14,15 There is uncertainty as to the cause of the observed widened basal diameter.…”

Section: Discussionmentioning

confidence: 99%

Real world outcomes of ocriplasmin use by members of the British and Eire Association of Vitreoretinal Surgeons

Haynes

Yorston

Laidlaw

et al. 2016

Eye

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Purpose To describe a survey of the use of ocriplasmin by members of the British and Eire Association of VitreoRetinal Surgeons (BEAVRS) for VitreoMacular Traction (VMT) and Full Thickness Macular Hole (FTMH) and compare it to published MIVI TRUST trial data. Methods All 173 BEAVRS members were contacted by email in October 2014 requesting data on all cases treated with ocriplasmin up to that date. The total number of cases, FTMH closure rate, VMT release rate and the frequency of adverse events were recorded. Results were compared with trial data. Results 48 members responded reporting results from 241 eyes. The respective BEAVRS and MIVI TRUST trial closure rates for small FTMHs were 42.1 and 58.3% (P = 0.09) and for medium FTMH 12.7 and 36.7% (P = 0.01). The respective VMT release rates were 34.1 and 37.4% (P = NS). Retinal detachment was observed in 3.3% of the BEAVRS cohort compared with 0.4% in MIVI TRUST. Reduction in visual acuity to o6/60 was observed in 5.8% of the BEAVRS cohort and 0.6% in MIVI TRUST. Other complications not reported in the MIVI TRUST trial included an increase in FTMH basal diameter following unsuccessful ocriplasmin use in 46.9% of BEAVRS cases and zonular instability at the time of subsequent phacoemulsification in 2.4%. Conclusion Macular hole closure rates were lower in the BEAVRS survey than published in the MIVI TRUST trial data. The incidence of adverse events was greater than previously reported. The reasons for these disparities are unknown but could include positive reporting bias inherent to retrospective surveys, treatment and population differences.

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Section: Discussionmentioning

confidence: 99%

Real world outcomes of ocriplasmin use by members of the British and Eire Association of Vitreoretinal Surgeons

Haynes

Yorston

Laidlaw

et al. 2016

Eye

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“…Although it is well known that the cause of a rhegmatogenous retinal detachment is a retinal defect, it has been pointed out by several authors (Colyear and Pischel, 1956;Okun, 1961;Davis, 1974;Byer, 1982) that retinal defects do not always lead to retinal detachment. On the other hand there is general agreement that symptomatic breaks in a high percentage Pischel, 1956, 1960 -28%;Davis, 1974 -35%) can lead to retinal detachment.…”

Section: Discussionmentioning

confidence: 99%

Analysis of prophylactic laser coagulation of retinal defects and degenerations performed in patients of the Free University of Amsterdam during the period from 1982 to July 1986

1987

Doc Ophthalmol

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In order to evaluate the prophylactic effect on retinal detachment a retrospective analysis was made of the prophylactic laser coagulations for retinal defects and degenerations performed on patients of the Free University of Amsterdam during the period from 1982 to July 1986. The main conclusion is that in a total of 273 treated eyes only two developed a spontaneous retinal detachment after coagulation. This is an incidence of 0.7%, which compares favourably with untreated groups. The treatment criteria were: 1. symptomatic defects; 2. defects and degenerations in fellow eyes; 3. asymptotic defects in aphakia, myopia greater than 5 D, single eyes and a positive family history. The most frequent complication was vitreous haemorrhage due to rupture of a patent vessel bridging the detached lip of a horseshoe tear, but vision was restored to normal in all but one case after the haemorrhage cleared.

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“…In the only reported series of patients with untreated flap tears seen before cataract extraction, five out of six patients went on to ARD.4 This poor prognosis is not sur¬ prising, since symptomatic flap tears in phakic eyes do equally poorly. [5][6] And, if the fellow eye has had a de¬ tachment, 20% of phakic eyes with holes later develop a retinal detach¬ ment.2 Thus, it would seem that such tears should be treated before cata¬ ract removal. As for other types of retinal abnormalities seen before cataract surgery, there is no informa¬ tion available.…”

Section: Commentmentioning

confidence: 99%

Aphakic Retinal Detachment

Benson¹

1975

Arch Ophthalmol

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Clinical Tears in the Retina without Detachment*

Cited by 52 publications

References 13 publications

Real world outcomes of ocriplasmin use by members of the British and Eire Association of Vitreoretinal Surgeons

Real world outcomes of ocriplasmin use by members of the British and Eire Association of Vitreoretinal Surgeons

Analysis of prophylactic laser coagulation of retinal defects and degenerations performed in patients of the Free University of Amsterdam during the period from 1982 to July 1986

Aphakic Retinal Detachment

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