Clinical survey of the imino-imidazolidine derivative STH 2130 for its sedative properties in comparison to acepromazine (Sedalin) and its use as preanesthetic in horses

Nautrup, B Poulsen; Keller, Harry F.

doi:10.21836/pem19890301

Cited by 15 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…imino) imidazolidine monohydrochloride, is an iminoimidazolidine derivative a,-adrenoceptor agonist drug developed from clonidine. Romifidine has been available since 1985 and, following investigations into its pharmacology in laboratory animals, it was released for clinical trials in the horse in 1988 (Poulsen Nautrup 1988, Voegtli 1988). It has recently been licensed in several countries solely for use in the horse, although there have been a number of studies of its use in the dog and cat others 1994, Gomez-Villamandos andothers 1994).…”

Section: Introductionmentioning

confidence: 99%

“…In the horse, romifidine has been shown to be useful for sedation to allow minor clinical procedures, and for premedication (Poulsen Nautrup and Keller 1989, Diamond and others 1993, Kannegieter 1993, Keller and Genzow 1994, Kerr and others 1994. Its effects have been shown to be similar to other a,-adrenoceptor agonists in this species with some minor differences (England and others 1992).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Romifidine as a premedicant to propofol induction and infusion anaesthesia in the dog

England

Andrews

Hammond

1996

J of Small Animal Practice

View full text Add to dashboard Cite

The effects of premedication with four different intravenous doses of romifidine (20, 40, 80 and 120 micrograms/kg bodyweight) and a saline placebo were compared in a group of 20 adult beagles of both sexes, undergoing anaesthesia with propofol for a clinical dental procedure. Anaesthesia was induced 10 minutes after premedication and maintained by intravenous infusion of propofol for a period of 30 minutes. Romifidine had a marked synergistic effect with propofol and reduced the required induction and infusion doses by more than 60 per cent for a standard level of anaesthesia; the synergistic effect was dose related. Following premedication, propofol produced no significant alteration of respiratory rate, heart rate or rectal temperature. Anaesthesia was found to be more stable following romifidine premedication at all doses studied. The quality of induction was unaltered by the dose of the romifidine. Recovery from anaesthesia was smooth and of a similar quality in all cases. There were no differences in the recovery times between the unpremedicated group and the dogs premedicated with any dose of romifidine studied. There were no adverse effects noted following this anaesthetic regimen. The marked dose-related synergism with propofol induction and infusion anaesthesia is relevant should romifidine be used in the dog in clinical veterinary practice.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Romifidine as a premedicant to propofol induction and infusion anaesthesia in the dog

England

Andrews

Hammond

1996

J of Small Animal Practice

View full text Add to dashboard Cite

show abstract

“…Romifidine is a potent and selective a2-adrenoceptor agonist, closely related chemically to clonidine, which has been used recently for both sedation and pre-medication in horses (Poulsen-Nautrup 1988;Voegtli 1988). Doses of 80 pg/ kg bodyweight (bwt) romifidine given intravenously (iv) appear to produce maximal sedation, higher doses lengthening the effect (Voegtli, 1988).…”

Section: Introductionmentioning

confidence: 99%

Sedative and cardiovascular effects of romifidine, alone and in combination with butorphanol, in the horse

Clarke

England

Goossens

1991

Journal of Veterinary Anaesthesia

View full text Add to dashboard Cite

“…). Several pharmacodynamic/pharmacokinetic studies have shown a prolonged sedative effect at the higher doses and a phase of residual sedation, detectable for 10 h after drug administration (Poulsen Nautrup ; England et al . ; Wojtasiak‐Wypart et al .…”

Section: Introductionmentioning

confidence: 99%

“…Romifidine in horses is usually administered intravenously (IV) at a dosage ranging from 40 to120 lg/kg (Freeman et al 2002;Figueiredo et al 2005). Several pharmacodynamic/pharmacokinetic studies have shown a prolonged sedative effect at the higher doses and a phase of residual sedation, detectable for 10 h after drug administration (Poulsen Nautrup 1988;England et al 1992;Wojtasiak-Wypart et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic profile and partitioning in red blood cells of romifidine after single intravenous administration in the horse

Romagnoli¹,

Al-Qudah²,

Armorini

et al. 2017

Veterinary Medicine & Sci

View full text Add to dashboard Cite

The aims of this study were to assess the plasma concentrations of romifidine in horses after intravenous injection, to evaluate the red blood cell (RBC) partitioning of the anaesthetic drug, and to improve knowledge regarding its sedative effect in horses describing the pharmacokinetic model. Eight adult Standardbred horses received a single bolus of romifidine at a dosage of 100 μg/kg. Blood samples (5 mL) were collected immediately before romifidine administration (t 0), and at 2, 5, 10, 15, 20, 25, 30, 40, 50, 60, 75, 90, 105, 120, 150 and 180 min after injection. A sedation score was recorded at the same time. The romifidine concentrations in plasma and red blood cells were determined by high performance liquid chromatography (HPLC). The plasma and red blood cell concentrations were correlated with the sedation at each time point. Romifidine produced a satisfactory level of sedation in all animals. The sedation was detectable in all horses for up to 105 min. All the animals returned to normal without any behavioural changes at 180 min. The romifidine concentrations in the red blood cells were significantly higher (P < 0.01) at all time points than those in the plasma. The T1/2β was 148.67 ± 61.59 min and body clearance was 22.55 ± 6.67 mL/kg per min. The results showed that after a single bolus administration of romifidine, a partitioning in the RBCs was detected.

show abstract

Clinical survey of the imino-imidazolidine derivative STH 2130 for its sedative properties in comparison to acepromazine (Sedalin) and its use as preanesthetic in horses

Cited by 15 publications

References 0 publications

Romifidine as a premedicant to propofol induction and infusion anaesthesia in the dog

Romifidine as a premedicant to propofol induction and infusion anaesthesia in the dog

Sedative and cardiovascular effects of romifidine, alone and in combination with butorphanol, in the horse

Pharmacokinetic profile and partitioning in red blood cells of romifidine after single intravenous administration in the horse

Contact Info

Product

Resources

About