Clinical study on the effects of the applied volume of moisturizer in patients with asteatosis

Abstract

Asteatosis, also xeroderma, is caused by decreased water content of the epidermal stratum corneum resulting from a decrease in moisture retention factors (subcorneal intercellular lipids, natural moisturizing factors, sebum, and sweat), and a decrease in the barrier function is observed in some patients. 1 Factors that cause asteatosis are physiological factors (such as age-related changes), habits (such as excessive body washing), pathological factors (such as diabetes mellitus, chronic kidney disease, anticancer drug treatment, or dialysis

Recent Advances in Phytochemical-Based Topical Applications for the Management of Eczema: A Review

“…Scratching, which is known to worsen AD, disrupts the skin barrier and leads to asteatosis or dry and fissured skin [87,88]. Moisturizers target four interdependent layers of the skin barrier (physical, chemical, microbiologic, and immunologic), support homeostasis, and facilitate the management of AD [89].…”

“…Clinical studies show that the volume of moisturizer applied to patients with asteatotic eczema influences the effectiveness of the treatment. In a single-center, randomized, single-blind (evaluator-blind), dose-comparison study with parallel-dose groups, the results suggested that the application of a dose equivalent to one finger-tip unit of the moisturizer twice daily led to faster remission [88]. Over the last two decades, moisturizer manufacturers have progressed in incorporating bioactive natural ingredients, especially phytochemicals, to improve barrier repair and emollient functions [90].…”