Clinical Study of the Paranasal Sinuses of Patients with Japanese Cedar Pollinosis

Hama, Takemitsu; Miyazaki, Makoto; Dejima, Kenji; Hisa, Yasuo; Fujieda, Shigeharu; Saitô, Hitoshi; Imanaka, Masashi; Kawata, Ryo; Takenaka, Hiroshi

doi:10.3950/jibiinkoka.105.1078

Cited by 1 publication

(2 citation statements)

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“…Cedar pollinosis is an IgE‐mediated type I allergy with symptoms, such as allergic rhinitis, sinusitis, and rhinoconjunctivitis. Every pollen season in Japan, more than 20 million people suffer from this disease 1–5 …”

Section: Introductionmentioning

confidence: 99%

“…Every pollen season in Japan, more than 20 million people suffer from this disease. [1][2][3][4][5] Cumulative exposure to cedar pollen is the most important factor responsible for the induction of allergen-specific Th2-type responses. 1,[6][7][8] However, even in cases where sensitization with Japanese cedar pollen is proven serologically, 50% of the people do not develop symptoms.…”

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confidence: 99%

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Staphylococcus aureus nasal colonization increases the risk of cedar pollinosis

Morizane

Uehara

Kitamura

et al. 2022

J of Gen and Family Med

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Background One‐third of the people in Japan are colonized with Staphylococcus aureus (S. aureus) and suffer from virulence factor‐mediated subclinical inflammation of the nares. We investigated whether subclinical inflammation contributed to cedar pollinosis affecting 20 million people annually. Methods The study participants were 814 inhabitants of the A or B prefectures. We compared the colonization rate and population structure of S. aureus, in association with the prevalence of cedar pollinosis, between participants in these two areas. Results A prefecture had twice the annual amount of airborne cedar pollen compared with B. The prevalence of cedar pollinosis was significantly higher in A (23.5%) than in B (13.1%) (p = 0.0004). Moreover, the prevalence of cedar pollinosis was higher in female participants (23.3%) than in male participants (14.7%) (p = 0.003). In addition, the prevalence of cedar pollinosis was higher in S. aureus carriers (24.2%) than in S. aureus noncarriers (17.9%) (p = 0.03). The isolation rate of clonal complex (CC) 508 was higher in the A group (21%) than in the B group (7%) (p = 0.015). Conclusion Nasal colonization of S. aureus is a major risk factor for cedar pollinosis. However, the direct mechanism of this risk is currently unknown.

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Section: Introductionmentioning

confidence: 99%