Clinical study of harvesting lymph nodes with carbon nanoparticles in advanced gastric cancer: a prospective randomized trial

Li, Ziyu; Ao, Sheng; Bu, Zhaode; Wu, Aiwen; Wu, Xiaojiang; Shan, Fei; Ji, Xin; Zhang, Yan; Xing, Zhaodong; Ji, Jiafu

doi:10.1186/s12957-016-0835-3

Cited by 60 publications

(58 citation statements)

References 16 publications

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“…Furthermore, in the CN group, the mean time for LN retrieval was shorter than that in the control group (27.6 vs. 34.6 min, p < 0.001) (45). Li et al conducted a prospective randomized trial to evaluate the efficiency and safety of CN for retrieving LNs in advanced GC (47). In the experimental group, 1.0 mL of CN was injected into the subserosa of the stomach at five points around the tumor about 10 min before open gastrectomy with D2 dissection.…”

Section: Discussionmentioning

confidence: 99%

The Methods of Lymph Node Examination Make a Difference to Node Staging and Detection of N3b Node Status for Gastric Cancer

Chen

et al. 2020

Front. Oncol.

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Background: The number of retrieved lymph nodes (RLNs) affects the likelihood of detecting metastatic lymph nodes (MLNs) for gastric cancer (GC), but the retrieval of LNs is not satisfactory worldwide. There is no standard for LN examination.Methods: We retrospectively analyzed 2,163 patients diagnosed with GC who underwent surgery at Nanfang Hospital between October 2004 and September 2016. According to the methods of LN examination, patients were classified into two groups: LN detection by pathologists (pathologist group) and LN examination by surgicopathologic team (surgicopathologist group). The relationship between RLNs and LN staging accuracy as well as the factors influencing the detection of MLNs were evaluated.Results: There were 472 males in pathologist group and 467 males in surgicopathologist group. The number of RLNs and MLNs in surgicopathologist group was significantly higher than that in pathologist group (RLNs: 53.8 ± 20.9 vs. 18.8 ± 11.5, p < 0.001; MLNs: 5.6 ± 9.8 vs. 3.9 ± 5.7, p < 0.001). Notably, the detection of N3b node status was significantly improved in surgicopathologist group [83 (11.9%) vs. 34 (4.8%), p < 0.001]. Additionally, the detection rate of N3b status gradually increased from 0 in patients with 1-16 RLNs to 16.6% in patients with more than 49 RLNs. The MLNs detected increased gradually from 2.3 ± 3.0 in patients with 1-16 RLNs to 7.3 ± 11.7 in patients with more than 49 RLNs. Univariate and multivariate analyses indicated that LN examination by surgicopathologic team, more advanced pT, tumor size ≥5 cm and combined organ(s) resection were related to detecting more MLNs. Conclusions:The retrieval of nodes immediately postoperatively by the surgicopathologic team could significantly improve the number of RLNs, detect more MLNs, and screen more patients with N3b node status.

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Section: Discussionmentioning

confidence: 99%

The Methods of Lymph Node Examination Make a Difference to Node Staging and Detection of N3b Node Status for Gastric Cancer

Chen

et al. 2020

Front. Oncol.

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“…Dozens of papers have demonstrated the lymph node mapping by CNSI. [1][2][3][4][5][6][7] Other particles, such as carbon dots, 27 magnetic nanoparticles 28 and semiconductor quantum dots, 29 also showed migration toward TDLN. In addition, the imaging of lymph nodes was achieved using CNSI, too.…”

Section: Mapping Of 13 C-cnps In Tdlnmentioning

confidence: 99%

“…4 Li et al harvested lymph nodes with CNSI in advanced gastric cancer. 5 CNSI does not stain the parathyroid gland during the thyroid carcinoma surgery, thus could reduce the risk of false resection. Zhu et al performed the CNSI-guided central lymph node dissection in patients with papillary thyroid carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Skeleton labeled <sup>13</sup>C-carbon nanoparticles for the imaging and quantification in tumor drainage lymph nodes

Xie¹,

Qian²,

Yang³

et al. 2017

IJN

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Carbon nanoparticles (CNPs) have been widely used in tumor drainage lymph node (TDLN) imaging, drug delivery, photothermal therapy, and so on. However, during the theranostic applications, the accumulation efficiency of CNPs in target organs is unknown yet, which largely hinders the extension of CNPs into clinical uses. Herein, we prepared skeleton-labeled 13 C-CNPs that had identical properties to commercial CNPs suspension injection (CNSI) for the imaging and quantification in TDLN. 13 C-CNPs were prepared by arc discharge method, followed by homogenization with polyvinylpyrrolidone. The size distribution and morphology of 13 C-CNPs were nearly the same as those of CNSI under transmission electron microscope. The hydrodynamic radii of both 13 C-CNPs and CNSI were similar, too. According to X-ray photoelectron spectroscopy and infrared spectroscopy analyses, the chemical compositions and chemical states of elements were also nearly identical for both labeled and commercial forms. The skeleton labeling of 13 C was reflected by the shift of G-band toward lower frequency in Raman spectra. 13 C-CNPs showed competitive performance in TDLN imaging, where the three lymph nodes (popliteal lymph node, common iliac artery lymph node, and paraaortic lymph node) were stained black upon the injection into the hind extremity of mice. The direct quantification of 13 C-CNPs indicated that 877 μg/g of 13 C-CNPs accumulated in the first station of TDLN (popliteal lymph node). The second station of TDLN (common iliac artery lymph node) had even higher accumulation level (1,062 μg/g), suggesting that 13 C-CNPs migrated efficiently along lymphatic vessel. The value decreased to 405 μg/g in the third station of TDLN (paraaortic lymph node). Therefore, the 13 C-CNPs provided quantitative approach to image and quantify CNSI in biological systems. The implication in biomedical applications and biosafety evaluations of CNSI is discussed.

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“…Therefore, the examined lymph nodes count by pathologists might be lower than the dissected lymph nodes count. Multiple attempts have been conducted to improve the detection rate of lymph nodes [26][27][28]. Li et al elucidated that the mean number of RLNs could be signi cantly elevated by injecting carbon nanoparticles before surgery compared with controls (38.33 vs 28.27) [26].…”

Section: Discussionmentioning

confidence: 99%

Impact of retrieved lymph nodes count on short-term complications in patients with gastric cancer

Sun

Liu

Song

et al. 2020

Preprint

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Background: It is well established that retrieved lymph nodes (RLNs) count were positively correlated with better overall survival in gastric cancer (GC). But little is known about the relationship between RLNs count and short-term complications after radical surgery. Methods: A total of 1487 consecutive GC patients between January 2016 and December 2018 at Nanjing Drum Tower Hospital were retrospectively analyzed. Univariate analyses were performed to elucidate the association between RLNs count and postoperative complications. We further identified clinical factors that might affect the RLNs count. Results: Among all of the patients, postoperative complications occurred in 435 (29.3%) patients. The mean RLNs count was 25.1 and 864 (58.1%) patients were diagnosed with lymph node metastasis. Univariate analyses showed no significant difference between RLNs count and postoperative complications (both overall and stratified by CDC grade). Univariate and multivariate analyses further revealed that type of resection, tumor invasion, and lymph node metastasis were associated with RLNs count. Conclusions: The current study demonstrated that RLNs count was not associated with postoperative short-term complications following gastrectomy of GC, which provided a rationale for the determination of a proper RLNs count of curative gastrectomy.

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Clinical study of harvesting lymph nodes with carbon nanoparticles in advanced gastric cancer: a prospective randomized trial

Cited by 60 publications

References 16 publications

The Methods of Lymph Node Examination Make a Difference to Node Staging and Detection of N3b Node Status for Gastric Cancer

The Methods of Lymph Node Examination Make a Difference to Node Staging and Detection of N3b Node Status for Gastric Cancer

Skeleton labeled <sup>13</sup>C-carbon nanoparticles for the imaging and quantification in tumor drainage lymph nodes

Impact of retrieved lymph nodes count on short-term complications in patients with gastric cancer

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